2001
Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease
Jagasia D, Whiting J, Concato J, Pfau S, McNulty P. Effect of Non–Insulin-Dependent Diabetes Mellitus on Myocardial Insulin Responsiveness in Patients With Ischemic Heart Disease. Circulation 2001, 103: 1734-1739. PMID: 11282903, DOI: 10.1161/01.cir.103.13.1734.Peer-Reviewed Original ResearchConceptsGlucose uptakeMyocardial insulin responsivenessCoronary disease patientsCoronary blood flowDependent diabetes mellitusIschemic heart diseaseMyocardium of patientsPoor clinical outcomeNet lactate uptakeCardiac glucose uptakeFractional extractionClinical outcomesDiabetes mellitusNon-InsulinInsulin levelsInsulin resistanceCardiac responsivenessDisease patientsInsulin infusionHeart diseaseMyocardial ischemiaPeripheral tissuesGlucose levelsBlood flowArterial plasmaSerum complement activation in congestive heart failure
Clark D, Cleman M, Pfau S, Rollins S, Ramahi T, Mayer C, Caulin-Glaser T, Daher E, Kosiborod M, Bell L, Setaro J. Serum complement activation in congestive heart failure. American Heart Journal 2001, 141: 684-690. PMID: 11275938, DOI: 10.1067/mhj.2001.113758.Peer-Reviewed Original ResearchConceptsCongestive heart failureSymptomatic heart failureC5b-9 levelsHeart failureClinical outcomesC5b-9Control patientsNew York Heart Association class IV symptomsComplement activationAge-matched control patientsClass IV symptomsCombined clinical outcomeAdverse clinical outcomesVentricular ejection fractionTerminal complement complex C5b-9Terminal complement activationComplement complex C5b-9Serum complement activationTerminal complement complexAdverse eventsCardiopulmonary bypassEjection fractionSerum levelsMyocardial injuryMyocardial infarction
2000
Effect of plasma insulin level on myocardial blood flow and its mechanism of action
McNulty P, Pfau S, Deckelbaum L. Effect of plasma insulin level on myocardial blood flow and its mechanism of action. The American Journal Of Cardiology 2000, 85: 161-165. PMID: 10955370, DOI: 10.1016/s0002-9149(99)00650-5.Peer-Reviewed Original ResearchConceptsMyocardial blood flowBlood flowInsulin levelsInsulin concentrationsCoronary sinus blood flowSystemic insulin levelsVenous plasma insulinSinus blood flowMyocardial oxygen demandCoronary blood flowCoronary heart diseasePlasma insulin levelsPlasma insulin concentrationMyocardial oxygen consumptionOxidative substrate metabolismMechanism of actionCoronary toneVasoactive substancesIntracoronary infusionCoronary endotheliumCoronary circulationPlasma insulinInsulin infusionHeart diseasePhysiologic elevations