Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs
Coelho C, Marquez S, Nguemwo Tentokam B, Berhe A, Miura K, Rao V, Long C, Doumbo O, Sagara I, Healy S, Kleinstein S, Duffy P. Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs. Npj Vaccines 2024, 9: 144. PMID: 39127706, PMCID: PMC11316794, DOI: 10.1038/s41541-024-00929-6.Peer-Reviewed Original ResearchHuman monoclonal antibodyBlocking parasite transmissionMalaria vaccinePlasmodium antigensImpact of adjuvantsClonotypic diversityHuman mAbsAS01Adjuvant groupVaccine designMalariaMonoclonal antibodiesAdjuvant selectionFunctional antibodiesAlhydrogelMAbGermline sequencesAntibodiesAntibody repertoireFunctional mAbsFunctional activityAdjuvantCohortIGHV1Vaccine