2001
Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c‐ret, directs lac Z (β‐galactosidase) expression in developing somatosensory system
Sukumaran M, Waxman S, Wood J, Pachnis V. Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c‐ret, directs lac Z (β‐galactosidase) expression in developing somatosensory system. Developmental Dynamics 2001, 222: 389-402. PMID: 11747074, DOI: 10.1002/dvdy.1192.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBase SequenceChromosome MappingCloning, MolecularConsensus SequenceDrosophila ProteinsEmbryo, MammalianGanglia, SensoryGene ExpressionGene Expression Regulation, DevelopmentalGenes, RegulatorGlial Cell Line-Derived Neurotrophic Factor ReceptorsLac OperonLectinsMiceMice, TransgenicNeurons, AfferentNociceptorsPromoter Regions, GeneticProtein Structure, TertiaryProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesSpinal CordTranscription Initiation SiteConceptsRegulatory domainLac Z expressionZ expressionCell type-specific expressionDistal regulatory domainEndogenous gene expressionCis-regulatory domainsTranscription initiation siteEntire structural geneSpecific regulatory domainsLac Z reporter geneStructural geneMouse genomeLateral mesodermRegulatory sequencesCpG islandsDNA sequencesPrimitive streakReporter geneFlanking sequencesCosmid contigGene expressionSpecific expressionTransgenic mouse lineInitiation site
1995
Differential up-regulation of sodium channel α- and β1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF
Zur K, Oh Y, Waxman S, Black J. Differential up-regulation of sodium channel α- and β1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF. Brain Research 1995, 30: 97-105. PMID: 7609649, DOI: 10.1016/0169-328x(94)00283-k.Peer-Reviewed Original ResearchConceptsSodium channel alphaNerve growth factorChannel alphaDRG neuronsCultured embryonic DRG neuronsΒ1 subunit mRNAPattern of expressionDorsal root ganglion neuronsSodium channel subunitsEmbryonic DRG neuronsPresence of NGFSitu hybridization cytochemistryAbsence of NGFBeta 1 mRNABeta-subunit mRNANAG mRNAChannel subunitsDevelopment proceedsSodium channel αE16 embryosGanglion neuronsMRNAAlpha-IIIChannel αAlpha II