2008
Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury
Deumens R, Joosten E, Waxman S, Hains B. Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury. Molecular Neurobiology 2008, 37: 52-63. PMID: 18415034, DOI: 10.1007/s12035-008-8016-1.Peer-Reviewed Original ResearchConceptsChronic painFiber sproutingAutonomic dysreflexiaMotor functionDorsal horn laminaePrimary afferent fibersSpinal cord injuryInterruption of connectionsDevelopment of therapiesMotor deficitsMotor dysfunctionNociceptive processingSensory fibersAfferent fibersCord injuryMotor fibersAberrant sproutingRegenerative sproutingSpinal cordLocomotor dysfunctionInhibitory barrierPainAxonal growthFiber tractsDysreflexia
1997
Downregulation of Na+ channel mRNA in olfactory bulb tufted cells following deafferentiation
Sashihara S, Waxman S, Greer C. Downregulation of Na+ channel mRNA in olfactory bulb tufted cells following deafferentiation. Neuroreport 1997, 8: 1289-1293. PMID: 9175131, DOI: 10.1097/00001756-199703240-00046.Peer-Reviewed Original ResearchConceptsOlfactory bulbMitral cellsEffects of deafferentationPostnatal day 2Olfactory receptor cellsFunctional deafferentationAfferent inputChannel expressionDay 2Channel mRNAReceptor cellsChannel subunitsDeafferentationI mRNACauterizationCritical periodDetectable changeAlpha IIOdorant accessSitu hybridizationCellsCell propertiesExpressionBulbMRNA
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1985
Retrograde labeling of regenerated electromotor neurons with HRP in a teleost fish, Sternarchus albifrons: Relation to cell death
Anderson M, Fong H, Waxman S. Retrograde labeling of regenerated electromotor neurons with HRP in a teleost fish, Sternarchus albifrons: Relation to cell death. Cell And Tissue Research 1985, 241: 237-240. PMID: 2411410, DOI: 10.1007/bf00217166.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAnimalsAxonal TransportCell SurvivalElectric OrganFishesHorseradish PeroxidaseMotor NeuronsRegenerationSpinal CordConceptsCorrect target areaElectromotor neuronsRetrograde labelingCell deathSelective neuronal deathSternarchus albifronsSubsequent cell deathNeuronal deathSpinal cordAxonal projectionsEctopic neuronsSelective cell deathTeleost fishImplantation sitesEctopic cellsNeuronsAxonsDeathCordAlbifronsTarget areaHorseradish peroxidase
1982
Intra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization
Kocsis J, Waxman S. Intra-axonal recordings in rat dorsal column axons: membrane hyperpolarization and decreased excitability precede the primary afferent depolarization. Brain Research 1982, 238: 222-227. PMID: 6282392, DOI: 10.1016/0006-8993(82)90787-9.Peer-Reviewed Original ResearchConceptsPrimary afferent depolarizationIntra-axonal recordingsRat lumbosacral spinal cordDorsal column stimulationDorsal root potentialsLumbosacral spinal cordDorsal column axonsDorsal columnsDorsal rootsAxonal depolarizationRoot potentialsSpinal cordGABA responsesNeuronal elementsIntracellular correlatesProlonged depolarizationMembrane hyperpolarizationHyperpolarizationDepolarizationExcitability
1981
Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium
Malenka R, Kocsis J, Ransom B, Waxman S. Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium. Science 1981, 214: 339-341. PMID: 7280695, DOI: 10.1126/science.7280695.Peer-Reviewed Original ResearchConceptsSynaptic field potentialsField potentialsParallel fiber stimulationExtracellular potassium concentrationRat cerebellar cortexParallel fibersAfferent fibersPostsynaptic elementsFiber excitabilityCerebellar cortexExtracellular potassiumFiber stimulationExcitabilityMarked increasePotassium concentrationStimulationMolecular layer