2012
The NaV1.7 sodium channel: from molecule to man
Dib-Hajj SD, Yang Y, Black JA, Waxman SG. The NaV1.7 sodium channel: from molecule to man. Nature Reviews Neuroscience 2012, 14: 49-62. PMID: 23232607, DOI: 10.1038/nrn3404.Peer-Reviewed Original ResearchConceptsDorsal hornPain disordersNerve endingsNociceptive dorsal root ganglion (DRG) neuronsPainful small fiber neuropathyDorsal root ganglion neuronsVoltage-gated sodium channel Nav1.7Small fiber neuropathyTreatment of painFree nerve endingsSecond-order neuronsSmall molecule blockersSodium channel Nav1.7Function mutationsOlfactory sensory neuronsProbability of neuronsNav1.7 sodium channelSuperficial laminaeGanglion neuronsRisk factorsSympathetic neuronsSlow depolarizationSpinal cordCardiac deficitsSensory neurons
2008
Alarm or curse? The pain of neuroinflammation
Saab C, Waxman S, Hains B. Alarm or curse? The pain of neuroinflammation. Brain Research Reviews 2008, 58: 226-235. PMID: 18486228, DOI: 10.1016/j.brainresrev.2008.04.002.Peer-Reviewed Original ResearchConceptsImmune cellsExperimental spinal cord injuryContribution of microgliaNociceptive nervous systemPeripheral nerve injuryExposure of neuronsSpinal cord injuryDevelopment of pharmacotherapiesNeuropathic injuryNeuropathic painNerve injuryPainful behaviorChronic painNeuroexcitatory effectsCord injuryChronic activationNervous systemPainImmune systemInjuryIdentification of moleculesNeuronsFunctional consequencesCellsDetrimental consequences
2001
Acquired channelopathies in nerve injury and MS
Waxman S. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56: 1621-1627. PMID: 11428390, DOI: 10.1212/wnl.56.12.1621.Peer-Reviewed Original ResearchMeSH KeywordsAxonsHumansMultiple SclerosisNeuralgiaParesthesiaPeripheral Nerve InjuriesPeripheral NervesPurkinje CellsSodium ChannelsConceptsNerve injurySodium channelsSensory neuron-specific sodium channelsSodium channel geneChannel genesPeripheral nerve injurySpinal sensory neuronsPathophysiology of MSSubtype-specific drugsDistinct sodium channelsVoltage-gated sodium channelsSpecific sodium channelsAxonal transectionGenetic channelopathyPrototype disorderSensory neuronsPurkinje cellsTherapeutic opportunitiesChannelopathiesAbnormal expressionInjuryMolecular changesHyperexcitabilityCellsTransection
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1987
Chapter 8 Ionic channel organization of normal and regenerating mammalian axons
Kocsis J, Waxman S. Chapter 8 Ionic channel organization of normal and regenerating mammalian axons. Progress In Brain Research 1987, 71: 89-101. PMID: 2438722, DOI: 10.1016/s0079-6123(08)61816-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsIon ChannelsMotor NeuronsNerve RegenerationNeurons, AfferentPeripheral NervesPotassiumSodiumConceptsNerve fibersPeripheral nervesRegenerated nerve fibersCell remodellingNormal developmentMammalian nerve fibresSchwann cellsElectrophysiological characteristicsFine caliberMyelinated axonsImmature axonsAxonal growthMammalian axonsNerveNormal maturationRemodelling occursAxonsCell arrestRemodellingTime courseMyelinIonic channelsLong termMaturationTime of maturation
1985
Myelin sheath remodelling in regenerated rat sciatic nerve
Hildebrand C, Kocsis J, Berglund S, Waxman S. Myelin sheath remodelling in regenerated rat sciatic nerve. Brain Research 1985, 358: 163-170. PMID: 2416385, DOI: 10.1016/0006-8993(85)90960-6.Peer-Reviewed Original ResearchConceptsRat sciatic nerveSciatic nerveRegenerated nervesAdult rat sciatic nerveRegenerated rat sciatic nerveNormal control nervesLight microscopic examinationAction potential waveformCrush lesionMonths survivalNerve segmentsControl nervesSame nerveIndividual nervesNerve fibersNerveShort sheathMyelin layersMyelin sheathPotassium channelsMicroscopic examinationLigature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance
Waxman S, Kocsis J, Eng D. Ligature‐induced injury in peripheral nerve: Electrophysiological observations on changes in action potential characteristics following blockade of potassium conductance. Muscle & Nerve 1985, 8: 85-92. PMID: 2414652, DOI: 10.1002/mus.880080202.Peer-Reviewed Original ResearchConceptsAction potentialsRepetitive firingSingle stimulusPotassium channelsCompound action potentialRat sciatic nerveAction potential propertiesWhole-nerve responseAction potential characteristicsIntra-axonal recordingsAction potential waveformNerve segmentsSciatic nerveNerve responsesPeripheral nervesInjury siteMyelinated fibersLater spikesElectrophysiological observationsNerveRefractory periodFiring patternsPotassium conductancePotential waveformInitial spike
1983
Maturation of mammalian myelinated fibers: changes in action-potential characteristics following 4-aminopyridine application
Kocsis J, Ruiz J, Waxman S. Maturation of mammalian myelinated fibers: changes in action-potential characteristics following 4-aminopyridine application. Journal Of Neurophysiology 1983, 50: 449-463. PMID: 6310062, DOI: 10.1152/jn.1983.50.2.449.Peer-Reviewed Original Research
1982
Diabetic Radiculoneuropathy: Clinical patterns of sensory loss and distal paresthesias
Waxman S. Diabetic Radiculoneuropathy: Clinical patterns of sensory loss and distal paresthesias. Acta Diabetologica 1982, 19: 199-207. PMID: 7148327, DOI: 10.1007/bf02624679.Peer-Reviewed Original Research
1977
Ferric ion, ferrocyanide, and inorganic phosphate as cytochemical reactants at peripheral nodes of Ranvier
Quick D, Waxman S. Ferric ion, ferrocyanide, and inorganic phosphate as cytochemical reactants at peripheral nodes of Ranvier. Brain Cell Biology 1977, 6: 555-570. PMID: 72787, DOI: 10.1007/bf01205219.Peer-Reviewed Original Research
1974
Ongoing activity in peripheral nerve: Injury discharge
Wall P, Waxman S, Basbaum A. Ongoing activity in peripheral nerve: Injury discharge. Experimental Neurology 1974, 45: 576-589. PMID: 4435078, DOI: 10.1016/0014-4886(74)90163-0.Peer-Reviewed Original Research
1972
Regional differentiation of the axon: A review with special reference to the concept of the multiplex neuron
Waxman S. Regional differentiation of the axon: A review with special reference to the concept of the multiplex neuron. Brain Research 1972, 47: 269-288. PMID: 4345196, DOI: 10.1016/0006-8993(72)90639-7.Peer-Reviewed Original Research