2010
Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination
Wilkins A, Kondo Y, Song J, Liu S, Compston A, Black J, Waxman S, Duncan I. Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination. Journal Of Neuropathology & Experimental Neurology 2010, 69: 1256-1269. PMID: 21107138, DOI: 10.1097/nen.0b013e3181ffc317.Peer-Reviewed Original ResearchConceptsCentral nervous systemAxonal lossAxonal degenerationAxonal pathologyTrophic supportEarly axonal lossProgressive axonal lossProgressive axonal degenerationWhite matter tractsTaiep mutant ratNerve countsWild-type controlsChronic demyelinationNeurologic disabilityMyelin lossSignificant inflammationRat modelOligodendrocyte dysfunctionImmunohistochemical analysisTaiep ratsNervous systemCNS regionsAxonal transportMutant ratsOligodendrocyte lineage
1990
Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons
Bhisitkul R, Kocsis J, Gordon T, Waxman S. Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons. Experimental Neurology 1990, 109: 273-278. PMID: 2170161, DOI: 10.1016/s0014-4886(05)80017-2.Peer-Reviewed Original ResearchConceptsDistal nerve segmentsGamma-aminobutyric acidNerve segmentsSciatic nerveReceptor expressionSensory neuronsTrophic supportGABAA receptor agonist muscimolDorsal root ganglion neuronsAxotomized sensory neuronsReactive Schwann cellsGABAA receptor expressionAdult sensory neuronsReceptor agonist muscimolExpression of receptorsPeripheral target tissuesGABA receptor expressionDorsal root fibersGABA receptor sensitivityEnd organ innervationPostoperative dayNerve crushNerve transectionCrush siteDistal stump