2002
Sodium channels and the molecular basis for pain
Black J, Cummins T, Dib-Hajj S, Waxman S. Sodium channels and the molecular basis for pain. Progress In Inflammation Research 2002, 23-50. DOI: 10.1007/978-3-0348-8129-6_2.ChaptersPrimary sensory neuronsSensory neuronsAction potentialsSpontaneous action potentialsHigh-frequency activityInflammatory painTrigeminal neuronsNociceptive responsesAscending pathwaysPeripheral nervesTissue injuryNoxious stimuliPeripheral targetsPainNeuronsSodium channelsTemperature sensationBrainHigh thresholdNerveMolecular basisInjuryAxonsDRG
2000
Voltage-gated sodium channels and the molecular pathogenesis of pain: a review.
Waxman SG, Cummins TR, Dib-Hajj SD, Black JA. Voltage-gated sodium channels and the molecular pathogenesis of pain: a review. The Journal Of Rehabilitation Research And Development 2000, 37: 517-28. PMID: 11322150.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsDRG neuronsNervous systemSodium channelsDistinct voltage-gated sodium channelsAction potentialsSpinal sensory neuronsSodium channel expressionSpontaneous action potentialsDifferent sodium channelsSpecific sodium channelsUnderstanding of painHigh-frequency activityInflammatory painPain pathwaysChronic painNociceptive signalsPeripheral nervesSensory neuronsNew therapiesPainChannel expressionMolecular pathogenesisPharmacologic manipulationNeuron cell membrane