2000
Development of Glutamatergic Synaptic Activity in Cultured Spinal Neurons
Robert A, Howe J, Waxman S. Development of Glutamatergic Synaptic Activity in Cultured Spinal Neurons. Journal Of Neurophysiology 2000, 83: 659-670. PMID: 10669482, DOI: 10.1152/jn.2000.83.2.659.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsCells, CulturedExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFetusGlutamic AcidMagnesiumMembrane PotentialsNeuronsPatch-Clamp TechniquesQuinoxalinesRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSpinal CordSynapsesTetrodotoxinConceptsSpontaneous synaptic activityCultured spinal neuronsSynaptic activitySpinal neuronsGlutamatergic synapsesSynaptic currentsGlutamatergic synaptic activityIsoxazolepropionic acid (AMPA) receptorsSpontaneous synaptic currentsOlder neuronsSynaptic NMDARsExogenous glutamateNMDARAcid receptorsSynaptic regionNeuronsReceptor openingSignificant increaseTime courseSynapsesSequence of eventsActivityWeeksCourseReceptors
1998
Endogenous NMDA-Receptor Activation Regulates Glutamate Release in Cultured Spinal Neurons
Robert A, Black J, Waxman S. Endogenous NMDA-Receptor Activation Regulates Glutamate Release in Cultured Spinal Neurons. Journal Of Neurophysiology 1998, 80: 196-208. PMID: 9658041, DOI: 10.1152/jn.1998.80.1.196.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnimalsAnimals, NewbornBicucullineCells, CulturedExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGlutamic AcidNeuronsRatsRats, Sprague-DawleyReceptors, AMPAReceptors, N-Methyl-D-AspartateSpinal CordSynapsesTetrodotoxinTime FactorsConceptsAMPA excitatory postsynaptic currentsExcitatory postsynaptic currentsNMDA receptor activationCultured spinal neuronsNMDA receptorsSpinal neuronsPresynaptic terminalsNMDA receptor-mediated glutamatergic neurotransmissionSpontaneous excitatory postsynaptic currentsAspartate receptor activationNMDA receptor activityRelease of neurotransmittersNonsynaptic receptorsTTX applicationGlutamate releaseImmature neuronsGlutamatergic neurotransmissionPostsynaptic currentsSpinal cordReceptor activationReceptor activityQuantal sizeQuantal analysisCNS developmentElectrical activity
1984
Cell death of asynaptic neurons in regenerating spinal cord
Anderson M, Waxman S, Tadlock C. Cell death of asynaptic neurons in regenerating spinal cord. Developmental Biology 1984, 103: 443-455. PMID: 6724138, DOI: 10.1016/0012-1606(84)90332-4.Peer-Reviewed Original ResearchConceptsSpinal cordElectromotor neuronsRegenerated cordNormal numbersNumber of perikaryaCell deathCaudal endRostro-caudal axisSpinal neuronsCordCell bodiesNeuronsSynaptic competitionAxonsNumerous cellsDeathPerikaryaAmputationMore yearsEvidence of migrationSternarchus albifronsExcess numberElectric organEpendymaTransverse sections
1983
Regeneration of spinal neurons in inframammalian vertebrates: morphological and developmental aspects.
Anderson M, Waxman S. Regeneration of spinal neurons in inframammalian vertebrates: morphological and developmental aspects. Journal Für Hirnforschung 1983, 24: 371-98. PMID: 6643991.Peer-Reviewed Original ResearchConceptsSpinal cordNerve cell bodiesSpinal neuronsCell bodiesNerve fibersAxon reactionElectromotor neuronsInframammalian vertebratesSpinal electromotor neuronsPeripheral nerve bridgesMammalian spinal cordCell deathNerve bridgeNew neuronsEpendymal cellsTrophic effectsCordNerve growthNeuronsNerve outgrowthCertain hormonesGrowth factorSternarchusExternal laminaAxon outgrowth
1982
Retrograde axon reaction following section of asynaptic nerve fibers
Waxman S, Anderson M. Retrograde axon reaction following section of asynaptic nerve fibers. Cell And Tissue Research 1982, 223: 487-492. PMID: 7093992, DOI: 10.1007/bf00218470.Peer-Reviewed Original Research
1972
MORPHOLOGICAL CORRELATES OF FUNCTIONAL DIFFERENTIATION OF NODES OF RANVIER ALONG SINGLE FIBERS IN THE NEUROGENIC ELECTRIC ORGAN OF THE KNIFE FISH STERNARCHUS
Waxman S, Pappas G, Bennett M. MORPHOLOGICAL CORRELATES OF FUNCTIONAL DIFFERENTIATION OF NODES OF RANVIER ALONG SINGLE FIBERS IN THE NEUROGENIC ELECTRIC ORGAN OF THE KNIFE FISH STERNARCHUS. Journal Of Cell Biology 1972, 53: 210-224. PMID: 5013596, PMCID: PMC2108696, DOI: 10.1083/jcb.53.1.210.Peer-Reviewed Original ResearchConceptsNodes of RanvierTypical nodeMorphological correlatesSurface areaMicroSingle nerve fibersElectron microscopyLarge nodesPacked layerSeries capacitySpinal neuronsTypical structureNerve fibersElectric organLevel of entrySingle fiberMembrane surface areaNeural originRunning segmentsAxonsNodal morphologyFiber axisFibersTypical appearanceUnique neural systems