2003
Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury
Hains B, Black J, Waxman S. Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. The Journal Of Comparative Neurology 2003, 462: 328-341. PMID: 12794736, DOI: 10.1002/cne.10733.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCortical motor neuronsFluoro-GoldCorticospinal tractCord injuryMotor neuronsTerminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphateAdult male Sprague-Dawley ratsRetrograde tracer Fluoro-GoldMale Sprague-Dawley ratsApoptotic cell deathDorsal corticospinal tractPrimary motor cortexTracer Fluoro-GoldSprague-Dawley ratsVoluntary motor controlTUNEL-positive cellsCell deathEvidence of apoptosisSham surgeryDorsal funiculusMotor cortexPyramidal cellsLesion sitePositive cells
1994
In situ hybridization localization of the Na+ channel β1 subunit mRNA in rat CNS neurons
Oh Y, Sashihara S, Waxman S. In situ hybridization localization of the Na+ channel β1 subunit mRNA in rat CNS neurons. Neuroscience Letters 1994, 176: 119-122. PMID: 7970226, DOI: 10.1016/0304-3940(94)90885-0.Peer-Reviewed Original ResearchConceptsBeta 1 mRNASpinal cordGranule cellsChannel beta 1 subunit (Na beta 1) mRNABeta 1 mRNA expressionDentate granule cellsAdult rat hippocampusCA1 pyramidal cellsRat CNS neuronsBeta 1 subunit mRNASitu hybridization histochemistryCNS neuronsPyramidal cellsRat hippocampusSitu hybridization localizationChannel β1Gray matterHybridization histochemistryPurkinje cellsMRNA expressionSubunit mRNAsModerate expressionDifferent neuronsStrong expressionNeurons
1990
Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus
O'Regan M, Kocsis J, Waxman S. Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus. Brain Research 1990, 527: 181-191. PMID: 1701335, DOI: 10.1016/0006-8993(90)91136-5.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCaffeineDihydropyridinesEvoked PotentialsFemaleHippocampusIn Vitro TechniquesLightMembrane PotentialsNeuronsNifedipineNimodipinePerfusionPotassiumPyramidal TractsRatsRats, Inbred StrainsSynapsesSynaptic TransmissionConceptsBay K 8644Synaptic transmissionDepressant actionIntracellular recordingsModerate membrane depolarizationMembrane depolarizationHippocampal brain slicesNormal Krebs solutionField potential responsesDepolarization-dependent increaseField potential analysisCA1 neuronsPresynaptic locusHippocampal slicesKrebs solutionPostsynaptic componentsPostsynaptic responsesPyramidal cellsNeuronal excitabilityRat hippocampusBrain slicesDirect depolarizationSpike thresholdDHP effectField potentials