2010
Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination
Wilkins A, Kondo Y, Song J, Liu S, Compston A, Black J, Waxman S, Duncan I. Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination. Journal Of Neuropathology & Experimental Neurology 2010, 69: 1256-1269. PMID: 21107138, DOI: 10.1097/nen.0b013e3181ffc317.Peer-Reviewed Original ResearchConceptsCentral nervous systemAxonal lossAxonal degenerationAxonal pathologyTrophic supportEarly axonal lossProgressive axonal lossProgressive axonal degenerationWhite matter tractsTaiep mutant ratNerve countsWild-type controlsChronic demyelinationNeurologic disabilityMyelin lossSignificant inflammationRat modelOligodendrocyte dysfunctionImmunohistochemical analysisTaiep ratsNervous systemCNS regionsAxonal transportMutant ratsOligodendrocyte lineage
2004
Chapter 5 Electrophysiologic Consequences of Myelination
Waxman S, Bangalore L. Chapter 5 Electrophysiologic Consequences of Myelination. 2004, 117-141. DOI: 10.1016/b978-012439510-7/50058-9.Peer-Reviewed Original ResearchImpulse conductionConduction abnormalitiesDemyelinated axonsRole of demyelinationRestoration of conductionTotal conduction blockNew therapeutic interventionsHigh-frequency trainsEntire myelin sheathMyelin lossClinical deficitsElectrophysiologic consequencesConduction blockPharmacological modulationConduction velocityTherapeutic interventionsAction potentialsDemyelinationMyelin sheathAxonsMolecular substratesSymptom productionAxonal membraneAbnormalitiesCurrent strategies
1976
Progressive multifocal neurologic deficit with disseminated subpial demyelination.
Galaburda A, Waxman S, Kemper T, Jones H. Progressive multifocal neurologic deficit with disseminated subpial demyelination. Journal Of Neuropathology & Experimental Neurology 1976, 35: 481-94. PMID: 182927, DOI: 10.1097/00005072-197609000-00001.Peer-Reviewed Original ResearchConceptsMyelin lossAcute urinary retentionModerate mononuclear pleocytosisMultifocal neurologic deficitsDistinct clinical entityYear old manUnusual clinical pictureNormal electrophoretic patternMononuclear pleocytosisUrinary retentionAxonal preservationNeurologic deficitsGait difficultyAstrocytic gliosisClinical entityClinical picturePerivascular cuffingSubpial demyelinationMononuclear cellsMyelinated fibersHistological examinationCerebrospinal fluidGross examinationCoronal sectionsDemyelination