2024
Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain
Vasylyev D, Zhao P, Schulman B, Waxman S. Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain. The Journal Of General Physiology 2024, 156: e202413596. PMID: 39378238, PMCID: PMC11465073, DOI: 10.1085/jgp.202413596.Peer-Reviewed Original ResearchConceptsDorsal root ganglionGain-of-function Nav1.7 mutationsDorsal root ganglion neuronsSodium channel Nav1.7Inherited erythromelalgiaNav1.7 mutationsNeuropathic painNeuronal hyperexcitabilityOpen-probabilityVoltage-gated sodium channel Nav1.7Hyperexcitability of DRG neuronsModel of neuropathic painSubthreshold membrane potential oscillationsResting membrane potentialMembrane potential oscillationsReduced firing probabilityIncreased rheobaseNav1.8 channelsDRG neuronsHuman genetic modelsNav1.8Root ganglionNav1.7 channelsNav1.7AP generation
2002
Subthreshold Oscillations Induced By Spinal Nerve Injury In Dissociated Muscle And Cutaneous Afferents Of Mouse DRG
Liu C, Devor M, Waxman S, Kocsis J. Subthreshold Oscillations Induced By Spinal Nerve Injury In Dissociated Muscle And Cutaneous Afferents Of Mouse DRG. Journal Of The Peripheral Nervous System 2002, 7: 212-212. DOI: 10.1046/j.1529-8027.2002.02026_27.x.Peer-Reviewed Original ResearchCutaneous afferentsMuscle afferentsNerve injuryDRG neuronsLumbar dorsal root ganglion neuronsWhole-cell patch-clamp recordingsCell patch-clamp recordingsDorsal root ganglion neuronsCutaneous afferent neuronsNerve injury groupSpinal nerves 1Spinal nerve injuryAction potential activityPatch-clamp recordingsSubthreshold membrane potential oscillationsMembrane potential oscillationsMembrane oscillationsWhole DRGInjury groupAfferent neuronsFluoro-GoldGanglion neuronsNerve 1Control neuronsTrue Blue