2022
Dendritic Spines and Pain Memory
Benson C, King J, Reimer M, Kauer S, Waxman S, Tan A. Dendritic Spines and Pain Memory. The Neuroscientist 2022, 30: 294-314. PMID: 36461773, DOI: 10.1177/10738584221138251.Peer-Reviewed Original ResearchNeuropathic painDendritic spinesSynaptic transmissionSpinal cord dorsal hornForm of painNew therapeutic approachesSurface of neuronsDorsal hornIntractable painDeep laminaePain memoryTherapeutic approachesPainNervous systemNew therapeuticsSpineMillions of peopleInjuryDiseaseRecent studiesReview articlePrevalenceNeuronsImportant role
2016
Voltage-Gated Ion Channels as Molecular Targets for Pain
Zamponi G, Han C, Waxman S. Voltage-Gated Ion Channels as Molecular Targets for Pain. 2016, 415-436. DOI: 10.1007/978-1-4899-7654-3_22.Peer-Reviewed Original ResearchVoltage-gated ion channelsDorsal root ganglion neuronsIon channelsMolecular targetsAction potential firing propertiesTreatment of painVoltage-gated sodiumImportant ion channelsNerve injuryGanglion neuronsPain signalingPeripheral afferentsPainFiring propertiesPharmacological modulatorsPotassium channelsTranslational researchDevelopment of modulatorsFunction changesHyperexcitabilityAfferentsInflammationMajor roleMajor themesInjury
2014
Dysfunction and recovery in demyelinated and dysmyelinated axons
Waxman S. Dysfunction and recovery in demyelinated and dysmyelinated axons. 2014, 457-471. DOI: 10.1017/cbo9780511995583.034.Peer-Reviewed Original ResearchNervous systemNeural repairNormal central nervous systemSpinal cord damageRecovery of functionCentral nervous systemNeuron replacementCerebral palsyCord damageAxonal regenerationNeuronal deathAxon regenerationNeurological rehabilitationBrain disordersCell therapyRehabilitation professionalsRepairRehabilitationBasic scienceStem cell biologyPalsyDysfunctionPathophysiologyInjuryTherapy
2009
Dorsal Root Ganglion Neurons
Rush A, Waxman S. Dorsal Root Ganglion Neurons. 2009, 615-619. DOI: 10.1016/b978-008045046-9.01660-0.Peer-Reviewed Original Research
2008
Alarm or curse? The pain of neuroinflammation
Saab C, Waxman S, Hains B. Alarm or curse? The pain of neuroinflammation. Brain Research Reviews 2008, 58: 226-235. PMID: 18486228, DOI: 10.1016/j.brainresrev.2008.04.002.Peer-Reviewed Original ResearchConceptsImmune cellsExperimental spinal cord injuryContribution of microgliaNociceptive nervous systemPeripheral nerve injuryExposure of neuronsSpinal cord injuryDevelopment of pharmacotherapiesNeuropathic injuryNeuropathic painNerve injuryPainful behaviorChronic painNeuroexcitatory effectsCord injuryChronic activationNervous systemPainImmune systemInjuryIdentification of moleculesNeuronsFunctional consequencesCellsDetrimental consequences
2006
Transcriptional Channelopathies of the Nervous System
Waxman S. Transcriptional Channelopathies of the Nervous System. 2006 DOI: 10.1002/9780470015902.a0006086.Peer-Reviewed Original ResearchSodium channel geneChannel genesTranscriptional channelopathiesSodium channel gene expressionChannel gene expressionGene expressionPeripheral nerve injurySpinal sensory neuronsGenesDysregulated expressionNerve injuryMultiple sclerosisSensory neuronsNervous systemCerebellar functionRecent studiesExpressionChannelopathiesAbstract Recent studiesHyperexcitabilitySclerosisInjuryNeuronsCellsFire and phantoms after spinal cord injury: Na+ channels and central pain
Waxman S, Hains B. Fire and phantoms after spinal cord injury: Na+ channels and central pain. Trends In Neurosciences 2006, 29: 207-215. PMID: 16494954, DOI: 10.1016/j.tins.2006.02.003.Peer-Reviewed Original ResearchConceptsSpinal cord injuryNeuropathic painCord injurySpinal cord dorsal horn neuronsDorsal horn neuronsNervous system injuryCentral painPain pathwaysSystem injuryThalamic neuronsPainAbnormal expressionPhantom phenomenaNeuronsInjuryMolecular targetsMolecular changesRecent findingsHyperexcitabilityNav1.3Molecular basisDysfunction and recovery in demyelinated and dysmyelinated axons
Waxman S. Dysfunction and recovery in demyelinated and dysmyelinated axons. 2006, 468-486. DOI: 10.1017/cbo9780511545061.029.Peer-Reviewed Original Research
2002
Sodium channels and the molecular basis for pain
Black J, Cummins T, Dib-Hajj S, Waxman S. Sodium channels and the molecular basis for pain. Progress In Inflammation Research 2002, 23-50. DOI: 10.1007/978-3-0348-8129-6_2.ChaptersPrimary sensory neuronsSensory neuronsAction potentialsSpontaneous action potentialsHigh-frequency activityInflammatory painTrigeminal neuronsNociceptive responsesAscending pathwaysPeripheral nervesTissue injuryNoxious stimuliPeripheral targetsPainNeuronsSodium channelsTemperature sensationBrainHigh thresholdNerveMolecular basisInjuryAxonsDRG
2001
Acquired channelopathies in nerve injury and MS
Waxman S. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56: 1621-1627. PMID: 11428390, DOI: 10.1212/wnl.56.12.1621.Peer-Reviewed Original ResearchConceptsNerve injurySodium channelsSensory neuron-specific sodium channelsSodium channel geneChannel genesPeripheral nerve injurySpinal sensory neuronsPathophysiology of MSSubtype-specific drugsDistinct sodium channelsVoltage-gated sodium channelsSpecific sodium channelsAxonal transectionGenetic channelopathyPrototype disorderSensory neuronsPurkinje cellsTherapeutic opportunitiesChannelopathiesAbnormal expressionInjuryMolecular changesHyperexcitabilityCellsTransection
2000
Experimental Approaches to Restoration of Function of Ascending and Descending Axons in Spinal Cord Injury
Waxman S, Kocsis J. Experimental Approaches to Restoration of Function of Ascending and Descending Axons in Spinal Cord Injury. Contemporary Neuroscience 2000, 215-239. DOI: 10.1007/978-1-59259-200-5_10.Peer-Reviewed Original ResearchSpinal cord injuryRestoration of functionCord injuryDemyelinated spinal cord axonsSpinal cord traumaResult of demyelinationSpinal cord axonsSubpopulation of axonsNormal action potentialCord traumaResidual axonsAxonal conductionSpinal cordConduction blockDescending axonsSCI researchAction potentialsAxonsDemyelinationInjurySignificant factor
1999
The role of voltage-gated Ca2+ channels in anoxic injury of spinal cord white matter
Imaizumi T, Kocsis J, Waxman S. The role of voltage-gated Ca2+ channels in anoxic injury of spinal cord white matter. Brain Research 1999, 817: 84-92. PMID: 9889329, DOI: 10.1016/s0006-8993(98)01214-1.Peer-Reviewed Original ResearchConceptsVoltage-gated Ca2Spinal cord axonsAnoxic injuryDorsal columnsR-type voltage-gated Ca2N-type calcium channelsSpinal cord white matterRat dorsal columnsDorsal column axonsR-type Ca2Rat spinal cordCord white matterT-type channelsInflux of Ca2Dose-dependent mannerLoss of conductionAxonal conductionSpinal cordChannel blockersCalcium channelsSurface stimulationWhite matterPerfusion solutionInjuryGlass microelectrodes
1997
Spinal Cord Repair: Progress Towards a Daunting Goal
Waxman S, Kocsis J. Spinal Cord Repair: Progress Towards a Daunting Goal. The Neuroscientist 1997, 3: 263-269. DOI: 10.1177/107385849700300414.Peer-Reviewed Original ResearchSpinal cord repairSpinal cordHuman spinal cord injuryUse of neurotrophinsSpinal cord injuryMyelin-forming glial cellsSpinal cord tractsFunctional recoveryNerve graftsAnatomical repairCord injuryGlial cellsAnimal modelsWhite matterGray matterClinical goalsCordInjuryPartial restorationRepairDaunting goalTransplantationNeurotrophinsGraftCNS
1996
White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications
Fern R, Ransom B, Waxman S. White Matter Stroke: Autoprotective Mechanisms with Therapeutic Implications. Cerebrovascular Diseases 1996, 6: 59-65. DOI: 10.1159/000107999.Peer-Reviewed Original ResearchWhite matterAnoxic injuryWhite matter strokeIncidence of strokeCNS white matterLevels of GABARecovery of functionResult of anoxiaIrreversible dysfunctionAnoxic insultPharmacological strategiesIrreversible injuryTherapeutic implicationsEndogenous storesExogenous GABAInjuryGABAAutoprotective mechanismsStrokeIntracellular eventsExtracellular spaceCa2Protective treatmentAdenosineInfluxAutoprotective mechanisms in the CNS
Fern R, Ransom B, Waxman S. Autoprotective mechanisms in the CNS. Journal Of Molecular Neuroscience 1996, 27: 107-129. PMID: 8962597, DOI: 10.1007/bf02815088.Peer-Reviewed Original ResearchMechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity
Rizzo M, Kocsis J, Waxman S. Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity. European Neurology 1996, 36: 3-12. PMID: 8719643, DOI: 10.1159/000117192.Peer-Reviewed Original ResearchConceptsAxonal injuryCutaneous afferentsDorsal root ganglion neuronsAction potential activityNormal sensory functionEctopic impulsesDRG neuronsClinical syndromeGanglion neuronsSensory functionMembrane excitabilityInjuryNerve impulsesDysesthesiaeChannel physiologyMolecular changesParesthesiaeAfferentsPreliminary evidenceNeuronsEctopicMolecular mechanismsSensory anatomyPotential activityPopulation
1995
Anoxic/ischemic injury in axons
STYS P, RANSOM B, BLACK J, WAXMAN S. Anoxic/ischemic injury in axons. 1995, 462-479. DOI: 10.1093/acprof:oso/9780195082937.003.0024.Peer-Reviewed Original ResearchNerve fibersNervous systemAnoxic/ischemic injuryPeripheral nervous systemAnoxia/ischemiaCentral nervous systemIschemic injuryPeripheral axonsAction potential propagationAxonsNormal functionPathological statesBiochemical homeostasisTransmembrane ion gradientsCellular energy metabolismInjuryEnergy metabolismPotential propagationSurvivalHuman diseasesMajor mechanismIon gradientsMembrane polarizationIschemiaDiseaseSelective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy
Rizzo M, Kocsis J, Waxman S. Selective loss of slow and enhancement of fast Na+currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiology Of Disease 1995, 2: 87-96. PMID: 8980012, DOI: 10.1006/nbdi.1995.0009.Peer-Reviewed Original Research
1994
Anoxic injury of rat optic nerve: ultrastructural evidence for coupling between Na+ influx and Ca2+-mediated injury in myelinated CNS axons
Waxman S, Black J, Ransom B, Stys P. Anoxic injury of rat optic nerve: ultrastructural evidence for coupling between Na+ influx and Ca2+-mediated injury in myelinated CNS axons. Brain Research 1994, 644: 197-204. PMID: 8050031, DOI: 10.1016/0006-8993(94)91680-2.Peer-Reviewed Original ResearchConceptsOptic nerveOptic nerve axonsRat optic nerveNerve axonsBrain slice chamberCompound action potentialLoss of cristaeMicroM tetrodotoxinAnoxic injuryNormoxic controlsNerveAstrocyte processesPerinodal astrocyte processesWhite matterMyelinated axonsAstrocytic processesCNS axonsTetrodotoxinAction potentialsSlice chamberAxonsLoss of microtubulesCytoskeletal damageInjuryNormoxic conditionsAnoxic Injury of Central Myelinated Axons: Nonsynaptic Ionic Mechanisms
Ransom B, Waxman S, Stys P. Anoxic Injury of Central Myelinated Axons: Nonsynaptic Ionic Mechanisms. 1994, 77-90. DOI: 10.1007/978-3-642-78151-3_9.Peer-Reviewed Original ResearchGlial cellsAnoxic injuryWhite matterCentral nervous system traumaIrreversible anoxic injuryPathophysiology of strokeNervous system traumaCentral myelinated axonsNeuronal cell bodiesAnoxia/ischemiaGray matter areasCNS axonal injuryNeuronal injuryIonic mechanismsAxonal injurySystem traumaCell injuryMyelinated axonsInjuryCell bodiesAxonsMatter areasBrainMetabolic substratesReliable model system