2005
6 The Conduction Properties of Demyelinated and Remyelinated Axons
Smith K, Waxman S. 6 The Conduction Properties of Demyelinated and Remyelinated Axons. 2005, 85-100. DOI: 10.1016/b978-012738761-1/50007-9.Peer-Reviewed Original ResearchRestoration of conductionConduction blockDemyelination-induced conduction blockExperimental demyelinating lesionsDemyelinating lesionsSegmental demyelinationMyelin thinningDemyelinated axonsElectrophysiological featuresConduction failureAxonal functionElectrophysiological propertiesDemyelinationAxonsMyelinLesionsIon channel populationsDemyelinated membraneChannel populationsAdaptive responseComplete loss
2004
Chapter 5 Electrophysiologic Consequences of Myelination
Waxman S, Bangalore L. Chapter 5 Electrophysiologic Consequences of Myelination. 2004, 117-141. DOI: 10.1016/b978-012439510-7/50058-9.Peer-Reviewed Original ResearchImpulse conductionConduction abnormalitiesDemyelinated axonsRole of demyelinationRestoration of conductionTotal conduction blockNew therapeutic interventionsHigh-frequency trainsEntire myelin sheathMyelin lossClinical deficitsElectrophysiologic consequencesConduction blockPharmacological modulationConduction velocityTherapeutic interventionsAction potentialsDemyelinationMyelin sheathAxonsMolecular substratesSymptom productionAxonal membraneAbnormalitiesCurrent strategies
1997
Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells
Waxman S, Kocsis J. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells. Altschul Symposia Series 1997, 283-298. DOI: 10.1007/978-1-4615-5949-8_28.Peer-Reviewed Original ResearchConduction velocityMyelinated axonsMyelin sheathNon-myelinated fibresClinical deficitsMyelin damageConduction abnormalitiesDemyelinated axonsSpinal cordGlial cellsMyelinated fibersConduction blockSynaptic terminalsAction potentialsRefractory periodCell bodiesDemyelinated fibersAxonsFunctional repair
1993
Molecular dissection of the myelinated axon
Waxman S, Ritchie J. Molecular dissection of the myelinated axon. Annals Of Neurology 1993, 33: 121-136. PMID: 7679565, DOI: 10.1002/ana.410330202.Peer-Reviewed Original ResearchConceptsMyelinated axonsInternodal axon membraneDemyelinated axonsCentral nervous system white matterNervous system white matterRestoration of conductionImportant therapeutic approachSchwann cell processesWhite matter axonsInflux of Ca2Important pathophysiological implicationsGlial cell processesAction potential conductionAxonal excitabilityGlial cellsAnoxic injuryMyelinated fibersTherapeutic approachesAstrocyte processesCell processesPathophysiological implicationsRepetitive firingWhite matterNeurological disordersAction potentials
1989
Demyelination in spinal cord injury
Waxman S. Demyelination in spinal cord injury. Journal Of The Neurological Sciences 1989, 91: 1-14. PMID: 2664092, DOI: 10.1016/0022-510x(89)90072-5.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryDemyelinated axonsFunctional recoveryCompressive spinal cord injuryAbsence of remyelinationRecovery of conductionRecovery of functionSmall-diameter axonsModification of conductionHemorrhagic necrosisPathophysiological basisClinical criteriaComplete transectionSchwann cellsDemyelinationDiameter axonsAction potentialsInjuryDemyelinated fibersAxonsRemyelinationNeurophysiological evidencePhysiological studiesTransection
1982
Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance
Kocsis J, Waxman S, Hildebrand C, Ruiz J. Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance. Proceedings Of The Royal Society B 1982, 217: 77-87. PMID: 6131423, DOI: 10.1098/rspb.1982.0095.Peer-Reviewed Original ResearchConceptsRegenerating axonsNerve fibersFiring propertiesAction potentialsPotassium conductancePotassium channelsCompound action potentialSciatic nerve fibersEarly regenerating axonsAction potential waveformRat nerve fibresMammalian nerve fibresDemyelinated axonsMyelinated fibersExtracellular applicationAxonsRecording techniquesSingle stimulusFiring characteristicsPotential waveformPresent study
1980
Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Electron-microscopic observations
Foster R, Kocsis J, Malenka R, Waxman S. Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum Electron-microscopic observations. Journal Of The Neurological Sciences 1980, 48: 221-231. PMID: 7431040, DOI: 10.1016/0022-510x(80)90202-6.Peer-Reviewed Original ResearchConceptsCorpus callosumLysophosphatidyl cholineFocal demyelinating lesionsCentral nervous systemDemyelinating lesionsLPC injectionDemyelinated axonsFocal demyelinationElectron microscopic examinationElectrophysiological studiesNervous systemElectrophysiological controlEarly signsCallosumAxonsDemyelinationInjectionElectron microscopic observationsRemyelinationPressure injectionLesions