2004
Chapter 5 Electrophysiologic Consequences of Myelination
Waxman S, Bangalore L. Chapter 5 Electrophysiologic Consequences of Myelination. 2004, 117-141. DOI: 10.1016/b978-012439510-7/50058-9.Peer-Reviewed Original ResearchImpulse conductionConduction abnormalitiesDemyelinated axonsRole of demyelinationRestoration of conductionTotal conduction blockNew therapeutic interventionsHigh-frequency trainsEntire myelin sheathMyelin lossClinical deficitsElectrophysiologic consequencesConduction blockPharmacological modulationConduction velocityTherapeutic interventionsAction potentialsDemyelinationMyelin sheathAxonsMolecular substratesSymptom productionAxonal membraneAbnormalitiesCurrent strategies
1998
Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord
Imaizumi T, Lankford K, Waxman S, Greer C, Kocsis J. Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord. Journal Of Neuroscience 1998, 18: 6176-6185. PMID: 9698311, PMCID: PMC2605360, DOI: 10.1523/jneurosci.18-16-06176.1998.Peer-Reviewed Original ResearchConceptsDorsal column axonsRat spinal cordSpinal cordRemyelinated axonsDorsal columnsAdult rat spinal cordExtent of remyelinationTransplantation of OECsSpinal cord lesionsCell injection siteQuantitative histological analysisFunctional remyelinationCord lesionsAxonal conductionNeonatal ratsFocal injectionsConduction blockSchwann cellsConduction velocityInjection siteElectrophysiological propertiesAction potentialsAxonsHistological analysisTransplantation
1997
Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells
Waxman S, Kocsis J. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells. Altschul Symposia Series 1997, 283-298. DOI: 10.1007/978-1-4615-5949-8_28.Peer-Reviewed Original ResearchConduction velocityMyelinated axonsMyelin sheathNon-myelinated fibresClinical deficitsMyelin damageConduction abnormalitiesDemyelinated axonsSpinal cordGlial cellsMyelinated fibersConduction blockSynaptic terminalsAction potentialsRefractory periodCell bodiesDemyelinated fibersAxonsFunctional repair
1983
Action potential propagation and conduction velocity — new perspectives and questions
Waxman S. Action potential propagation and conduction velocity — new perspectives and questions. Trends In Neurosciences 1983, 6: 157-161. DOI: 10.1016/0166-2236(83)90075-9.Peer-Reviewed Original Research
1982
Rat optic nerve: Electrophysiological, pharmacological and anatomical studies during development
Foster R, Connors B, Waxman S. Rat optic nerve: Electrophysiological, pharmacological and anatomical studies during development. Brain Research 1982, 3: 371-386. PMID: 7066695, DOI: 10.1016/0165-3806(82)90005-0.Peer-Reviewed Original ResearchConceptsCompound action potentialAction potentialsConduction velocityOptic nerveOptic nerve axonsShort latency peaksRat optic nerveAxonal membrane propertiesShort-latency componentsSixth postnatal dayOnset of myelinationWeeks of ageRelative refractory periodDays of ageGlial cellsPostnatal dayRefractory periodNerve axonsAxonal diameterLatency componentsCalcium conductanceAxonal sizeMyelinationNerve growthLatency peaks
1981
Effects of variations in temperature on impulse conduction along nonmyelinated axons in the mammalian brain
Swadlow H, Waxman S, Weyand T. Effects of variations in temperature on impulse conduction along nonmyelinated axons in the mammalian brain. Experimental Neurology 1981, 71: 383-389. PMID: 7449905, DOI: 10.1016/0014-4886(81)90096-0.Peer-Reviewed Original Research
1980
Determinants of conduction velocity in myelinated nerve fibers
Waxman S. Determinants of conduction velocity in myelinated nerve fibers. Muscle & Nerve 1980, 3: 141-150. PMID: 6245357, DOI: 10.1002/mus.880030207.Peer-Reviewed Original ResearchPathophysiology of nerve conduction: relation to diabetic neuropathy.
WAXMAN S. Pathophysiology of nerve conduction: relation to diabetic neuropathy. Annals Of Internal Medicine 1980, 92: 297-301. PMID: 6243892, DOI: 10.7326/0003-4819-92-2-297.Peer-Reviewed Original ResearchConceptsTotal conduction blockProximal-distal gradientClinicopathologic aspectsDiabetic neuropathyClinical deficitsElectrophysiologic variablesNerve diseasePathophysiologic mechanismsNerve conductionConduction blockPathologic basisConduction velocityImpulse conductionTopographic patternsTemporal dispersionNeuropathyNerveDysfunctionPathophysiologyLesionsDisease
1979
Variation in conduction velocity during the relative refractory and supernormal periods: A mechanism for impulse entrainment in central axons
Kocsis J, Swadlow H, Waxman S, Brill M. Variation in conduction velocity during the relative refractory and supernormal periods: A mechanism for impulse entrainment in central axons. Experimental Neurology 1979, 65: 230-236. PMID: 262231, DOI: 10.1016/0014-4886(79)90263-2.Peer-Reviewed Original Research
1978
Characteristics of interhemispheric impulse conduction between prelunate gyri of the rhesus monkey
Swadlow H, Rosene D, Waxman S. Characteristics of interhemispheric impulse conduction between prelunate gyri of the rhesus monkey. Experimental Brain Research 1978, 33: 455-467. PMID: 103739, DOI: 10.1007/bf00235567.Peer-Reviewed Original ResearchConceptsCallosal efferent neuronsPrior impulseAxonal conduction velocityConduction velocityPrelunate gyrusEfferent neuronsCorpus callosumSupernormal periodRhesus monkeysCell of originRelative refractory periodSubnormal periodAntidromic activationAntidromic latenciesElectrical stimulationImpulse conductionRefractory periodElectrophysiological techniquesGyrusCallosumMonkeysExcitabilityNeuronsPeriodSplenium
1977
Conduction in Myelinated, Unmyelinated, and Demyelinated Fibers
Waxman S. Conduction in Myelinated, Unmyelinated, and Demyelinated Fibers. JAMA Neurology 1977, 34: 585-589. PMID: 907529, DOI: 10.1001/archneur.1977.00500220019003.Peer-Reviewed Original ResearchConceptsDemyelinated fibersConduction failureConduction velocityEffective symptomatic therapyIdentification of agents
1976
Variations in conduction velocity and excitability following single and multiple impulses of visual callosal axons in the rabbit
Swadlow H, Waxman S. Variations in conduction velocity and excitability following single and multiple impulses of visual callosal axons in the rabbit. Experimental Neurology 1976, 53: 128-150. PMID: 964334, DOI: 10.1016/0014-4886(76)90288-0.Peer-Reviewed Original ResearchConceptsCallosal axonsAntidromic latenciesConduction velocityContralateral cortical stimulationMain axon trunkLatency decreaseCorticotectal axonsAntidromic activationAxon trunkCortical stimulationTest stimuliAwake rabbitsConditioning stimulusCell bodiesAxonsControl valuesThreshold shiftDifferent axonsConditioning pulseAppropriate intervalsPresent studyRabbitsDurationStimuliLatency
1975
Observations on impulse conduction along central axons.
Swadlow H, Waxman S. Observations on impulse conduction along central axons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1975, 72: 5156-5159. PMID: 1061101, PMCID: PMC388895, DOI: 10.1073/pnas.72.12.5156.Peer-Reviewed Original Research
1972
Relative Conduction Velocities of Small Myelinated and Non-myelinated Fibres in the Central Nervous System
WAXMAN S, BENNETT M. Relative Conduction Velocities of Small Myelinated and Non-myelinated Fibres in the Central Nervous System. Nature 1972, 238: 217-219. PMID: 4506206, DOI: 10.1038/newbio238217a0.Peer-Reviewed Original Research
1971
An ultrastructural study of the pattern of myelination of preterminal fibers in teleost oculomotor nuclei, electromotor nuclei, and spinal cord
Waxman S. An ultrastructural study of the pattern of myelination of preterminal fibers in teleost oculomotor nuclei, electromotor nuclei, and spinal cord. Brain Research 1971, 27: 189-201. PMID: 5552167, DOI: 10.1016/0006-8993(71)90248-4.Peer-Reviewed Original ResearchConceptsPattern of myelinationSpinal cordOculomotor nucleusElectromotor nucleusProportion of synapsesPreterminal fibersPeripheral nerve fibersCentral nervous systemCentral myelinated fibersNodes of RanvierUnmyelinated regionsNerve fibersMyelinated fibersConduction velocityNervous systemCordMyelinationNervous impulsesUltrastructural studySynapsesClose membrane appositionBulbous protrusionsMembrane appositionAxonsNucleus