1999
Changes in expression of voltage‐gated potassium channels in dorsal root ganglion neurons following axotomy
Ishikawa K, Tanaka M, Black J, Waxman S. Changes in expression of voltage‐gated potassium channels in dorsal root ganglion neurons following axotomy. Muscle & Nerve 1999, 22: 502-507. PMID: 10204786, DOI: 10.1002/(sici)1097-4598(199904)22:4<502::aid-mus12>3.0.co;2-k.Peer-Reviewed Original ResearchConceptsDorsal root ganglion neuronsDRG neuronsVoltage-gated potassium channelsAxonal injuryGanglion neuronsPotassium channelsChannel expressionNormal DRG neuronsChronic pain syndromeSodium channel expressionSpectrum of subtypesVoltage-gated sodium channelsSpecific potassium channelsPain syndromeDRG cellsAdult ratsNervous systemAxotomyKv expressionNeuronsImmunocytochemical methodsMolecular correlatesElectrical excitabilitySodium channelsImmunoreactivityIn Vivo NGF Deprivation Reduces SNS Expression and TTX-R Sodium Currents in IB4-Negative DRG Neurons
Fjell J, Cummins T, Fried K, Black J, Waxman S. In Vivo NGF Deprivation Reduces SNS Expression and TTX-R Sodium Currents in IB4-Negative DRG Neurons. Journal Of Neurophysiology 1999, 81: 803-810. PMID: 10036280, DOI: 10.1152/jn.1999.81.2.803.Peer-Reviewed Original ResearchConceptsTTX-R sodium currentsNerve growth factorPA/pFDRG neuronsHigh antibody titersSodium current densityNGF-deprived neuronsSodium currentAntibody titersAdult ratsSmall dorsal root ganglion neuronsTetrodotoxin-resistant sodium channelsDorsal root ganglion neuronsTTX-R currentsSodium channel expressionMRNA hybridization signalsPathological painThermal hypoalgesiaGanglion neuronsControl neuronsIsolectin IB4Channel expressionNGF deprivationMRNA expressionNeurons
1998
Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion
Lankford K, Waxman S, Kocsis J. Mechanisms of enhancement of neurite regeneration in vitro following a conditioning sciatic nerve lesion. The Journal Of Comparative Neurology 1998, 391: 11-29. PMID: 9527536, PMCID: PMC2605358, DOI: 10.1002/(sici)1096-9861(19980202)391:1<11::aid-cne2>3.0.co;2-u.Peer-Reviewed Original ResearchConceptsDorsal root gangliaConditioning lesionNerve injuryNerve regenerationAffected dorsal root ganglionControl dorsal root gangliaDenervated peripheral nervePrior nerve injurySciatic nerve lesionCultured DRG neuronsSciatic nerve transectionPeripheral target tissuesPeripheral nerve stumpRapid nerve regenerationAbility of neuronsSecond axotomyNerve lesionsDRG neuronsNerve transectionNerve stumpRoot gangliaControl neuronsPeripheral nervesNerve tractsAdult ratsAxon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study
Fern R, Davis P, Waxman S, Ransom B. Axon Conduction and Survival in CNS White Matter During Energy Deprivation: A Developmental Study. Journal Of Neurophysiology 1998, 79: 95-105. PMID: 9425180, DOI: 10.1152/jn.1998.79.1.95.Peer-Reviewed Original ResearchConceptsAnoxia/aglycemiaCompound action potentialWithdrawal of oxygenOptic nerveCNS white matterWhite matterIsolated rat optic nerveEvoked compound action potentialAdult optic nerveOptic nerve functionRat optic nervePostnatal day 10Permanent lossMin of glucoseEnergy deprivationWithdrawal of glucoseGlucose withdrawalNerve functionAstrocytic glycogenAxon conductionHeightened metabolic activityAdult ratsAglycemiaIrreversible injuryNerveResistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination
Imaizumi T, Kocsis J, Waxman S. Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination. Brain Research 1998, 779: 292-296. PMID: 9473700, DOI: 10.1016/s0006-8993(97)01171-2.Peer-Reviewed Original ResearchConceptsCompound action potentialDorsal columnsSpinal cordAction potentialsWhite matterSpinal cord dorsal columnAdult rat spinal cordAdult spinal cordRat spinal cordMin of reoxygenationAdult white matterAction potential conductionControl ratsFocal demyelinationAnoxic injurySupramaximal stimulationOnset of anoxiaAdult ratsDemyelinationPotential conductionCordX-irradiationRatsGreater recoveryOnset
1997
P-3-316 Functional repair of demyelinated spinal cordaxons in the adult rat by transplantation of genetically-engineering Schwann cells
Hommou O, Hashi K, Felts P, Waxman S, Kocsis J. P-3-316 Functional repair of demyelinated spinal cordaxons in the adult rat by transplantation of genetically-engineering Schwann cells. Clinical Neurology And Neurosurgery 1997, 99: s143. DOI: 10.1016/s0303-8467(97)81922-1.Peer-Reviewed Original ResearchNGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons
Black J, Langworthy K, Hinson A, Dib-Hajj S, Waxman S. NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons. Neuroreport 1997, 8: 2331-2335. PMID: 9243635, DOI: 10.1097/00001756-199707070-00046.Peer-Reviewed Original ResearchConceptsNeurotrophin nerve growth factorSmall DRG neuronsExogenous NGFDRG neuronsDifferent sodium channel genesSmall dorsal root ganglion neuronsDorsal root ganglion neuronsSciatic nerve transectionMRNA levelsSpinal sensory neuronsNerve growth factorNerve transectionDRG culturesGanglion neuronsAlpha-IIIAdult ratsSensory neuronsPeripheral targetsSodium channel transcriptsMRNA expressionMembrane excitabilityNeuronsGrowth factorRetrograde transportChannel transcripts
1996
Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides
Roy M, Saal D, Perney T, Sontheimer H, Waxman S, Kaczmarek L. Manipulation of the delayed rectifier Kv1.5 potassium channel in glial cells by antisense oligodeoxynucleotides. Glia 1996, 18: 177-184. PMID: 8915650, DOI: 10.1002/(sici)1098-1136(199611)18:3<177::aid-glia2>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsGlial cellsKv1.5 channel proteinSpinal cordKv1.5 proteinCultured spinal cordTEA-insensitive currentSpinal cord astrocytesRectifier current densityPotassium channel typesAntisense oligodeoxynucleotide treatmentKv1.5 potassium channelAdult ratsCerebellar slicesChannel proteinsAstrocytesOligodeoxynucleotide treatmentPotassium channelsRectifier currentEndfoot processesSuch treatmentCurrent activationAntisense oligodeoxynucleotidesCordCellsTreatment
1995
Na+ channel β1 subunit mRNA expression in developing rat central nervous system
Sashihara S, Oh Y, Black J, Waxman S. Na+ channel β1 subunit mRNA expression in developing rat central nervous system. Brain Research 1995, 34: 239-250. PMID: 8750827, DOI: 10.1016/0169-328x(95)00168-r.Peer-Reviewed Original ResearchConceptsGranule cell layerCell layerRat central nervous systemBeta 1Channel beta 1 subunitRexed's lamina IXDentate granule cellsPyramidal cell layerPostnatal day 2Beta 1 expressionSpecific neuronal populationsVentral-dorsal gradientCentral nervous systemSubunit mRNA expressionVoltage-dependent sodium channelsExternal granule cell layerInternal granule cell layerDorsal hornVentral hornLamina IXSpinal cordBeta 1 subunitAdult ratsIntensity of labelingGranule cellsExpression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat
Felts P, Black J, Waxman S. Expression of sodium channel α- and β-subunits in the nervous system of themyelin-deficient rat. Brain Cell Biology 1995, 24: 654-666. PMID: 7500121, DOI: 10.1007/bf01179816.Peer-Reviewed Original ResearchConceptsSodium channel αMale littermatesSubtype-specific riboprobesDorsal root gangliaChannel αNormal male littermatesSodium channel subunitsUnaffected male littermatesDays of ageAdult expression patternRoot gangliaSpinal cordExpression patternsAdult ratsNervous systemUnaffected littermatesSodium channelsLittermatesPattern of expressionChannel subunitsRatsGreater expressionSitu hybridization techniqueUnaffected animalsPrevious reports
1991
Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons
Utzschneider D, Kocsis J, Waxman S. Differential sensitivity to hypoxia of the peripheral versus central trajectory of primary afferent axons. Brain Research 1991, 551: 136-141. PMID: 1913145, DOI: 10.1016/0006-8993(91)90924-k.Peer-Reviewed Original ResearchConceptsDorsal columnsDorsal rootsAfferent fibersCentral nervous system componentsPrimary afferent fibersSucrose gap chamberAction potential amplitudePrimary afferent axonsCompound action potentialDorsal spinal rootsNervous system componentsAxonal trunksPeripheral nervesSpinal cordSpinal rootsAfferent axonsCNS portionSchwann cellsAdult ratsPotential amplitudeAxon branchesAction potentialsHypoxiaMembrane potential changesMembrane depolarization
1986
Remodelling of internodes in regenerated rat sciatic nerve: Electron microscopic observations
Hildebrand C, Mustafa G, Waxman S. Remodelling of internodes in regenerated rat sciatic nerve: Electron microscopic observations. Brain Cell Biology 1986, 15: 681-692. PMID: 3819776, DOI: 10.1007/bf01625187.Peer-Reviewed Original ResearchConceptsRegenerated rat sciatic nerveRat sciatic nerveSciatic nerveSchwann cellsMyelin sheathRegenerated myelin sheathsRegenerated nerve segmentsSchwann cell networkLeft sciatic nerveSchwann cell cytoplasmMyelin sheath breakdownNodes of RanvierCrush lesionNerve segmentsSurvival periodUpper thighAdult ratsSurvival timeNerveInternodal shorteningImportant physiological implicationsMonthsLipid dropletsLamellated bodiesExtensive remodelling
1985
Axo-glial relations in the retina-optic nerve junction of the adult rat: electron-microscopic observations
Hildebrand C, Remahl S, Waxman S. Axo-glial relations in the retina-optic nerve junction of the adult rat: electron-microscopic observations. Brain Cell Biology 1985, 14: 597-617. PMID: 4067610, DOI: 10.1007/bf01200800.Peer-Reviewed Original ResearchConceptsNerve junctionAdult ratsAstrocytic processesDeficient blood-brain barrierEctopic Schwann cellsFibrous astrocytic processesBlood-brain barrierAxo-glial contactsMyelination of axonsNumerous pinocytotic vesiclesTypical oligodendrocytesGlial ensheathmentGlial cellsUnmyelinated segmentsGlia limitansSchwann cellsUnmyelinated axonsWide perivascular spacesPia materPerivascular spacesOligodendroglial cellsDeficient proliferationUnmyelinated partMyelin sheathSame axon
1983
Freeze-fracture ultrastructure of developing and adult non-myelinated ganglion cell axolemma in the retinal nerve fibre layer
Black J, Foster R, Waxman S. Freeze-fracture ultrastructure of developing and adult non-myelinated ganglion cell axolemma in the retinal nerve fibre layer. Brain Cell Biology 1983, 12: 201-212. PMID: 6842274, DOI: 10.1007/bf01148462.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerNerve fiber layerNon-myelinated axonsFiber layerParticle densityMean particle diameterParticle diameterLayerNeonatal ratsElectron microscopyAdult ratsDistal segmentsParticlesConduction propertiesAdult fibersAdult animalsΜm2AxonsLow densityDensityDevelopmental ageFibersRatsHigh density