2004
A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin*
Li W, Walus L, Rabacchi SA, Jirik A, Chang E, Schauer J, Zheng BH, Benedetti NJ, Liu BP, Choi E, Worley D, Silvian L, Mo W, Mullen C, Yang W, Strittmatter SM, Sah DW, Pepinsky B, Lee DH. A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin*. Journal Of Biological Chemistry 2004, 279: 43780-43788. PMID: 15297463, DOI: 10.1074/jbc.m401803200.Peer-Reviewed Original ResearchConceptsOligodendrocyte myelin glycoproteinRat dorsal root ganglion neuronsDorsal root ganglion neuronsMonoclonal antibodiesMyelin glycoproteinNeurite outgrowthMyelin proteinsUseful therapeutic approachCNS myelin substrateNogo66 receptorCentral nervous system myelinGanglion neuronsTherapeutic approachesCNS repairMyelin substrateCentral nervous system myelin proteinsInhibitory effectNgR1AntibodiesNeurite growthMyelinSystem myelinReverses inhibitionMolecular epitopes
2002
Nogo-66 receptor antagonist peptide promotes axonal regeneration
GrandPré T, Li S, Strittmatter SM. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 2002, 417: 547-551. PMID: 12037567, DOI: 10.1038/417547a.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAxonsBinding, CompetitiveCentral Nervous SystemCulture Media, ConditionedFemaleGPI-Linked ProteinsGrowth ConesMolecular Sequence DataMotor ActivityMyelin ProteinsMyelin SheathNerve RegenerationNeuritesNogo Receptor 1Peptide FragmentsProtein Structure, TertiaryRatsRats, Sprague-DawleyReceptors, Cell SurfaceSpinal Cord InjuriesConceptsCentral nervous systemAxonal regenerationNogo-66NEP1-40Antagonist peptideAxonal outgrowthNogo-66 receptorPotential therapeutic agentCorticospinal tract regenerationAxonal outgrowth inhibitionCNS myelin inhibitionSignificant axon growthIntrathecal administrationFunctional recoveryCNS injuryCorticospinal tractOutgrowth inhibitorCompetitive antagonistNervous systemMyelin inhibitionTherapeutic agentsAxon growthMonoclonal antibodiesAdult mammalsNogo
1989
Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye.
Strittmatter SM, Braas KM, Snyder SH. Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye. Investigative Ophthalmology & Visual Science 1989, 30: 2209-14. PMID: 2551838.Peer-Reviewed Original ResearchConceptsCiliary epitheliumRat eyesLocalization of angiotensinAnti-ACE antibodiesAqueous humor productionACE immunoreactivityACE inhibitorsPotent ACE inhibitorPosterior chamberChoroid plexusImmunocytochemical stainingMonoclonal antibodiesChoroidal epitheliumVentricular surfaceEpitheliumAngiotensinHumor productionEyesMajor siteACEAntibodiesLow levelsHigh levelsPlexusImmunoreactivity
1987
Angiotensin converting enzyme immunohistochemistry in rat brain and pituitary gland: Correlation of isozyme type with cellular localization
Strittmatter SM, Snyder SH. Angiotensin converting enzyme immunohistochemistry in rat brain and pituitary gland: Correlation of isozyme type with cellular localization. Neuroscience 1987, 21: 407-420. PMID: 3039401, DOI: 10.1016/0306-4522(87)90131-x.Peer-Reviewed Original ResearchConceptsAngiotensin converting enzymeSubstantia nigraRat brainChoroid plexusPituitary glandPosterior pituitaryConverting enzymePituitary stalk sectionEntopeduncular nucleusSubfornical organCaudate putamenGlobus pallidusEnzyme immunoreactivityParaventricular nucleusAnterior pituitaryAngiotensinEnzyme inhibitorsPosterior lobeIntense stainingCell bodiesMonoclonal antibodiesDiffuse stainingEndothelial cellsEnzyme immunohistochemistryAntibody specificity
1984
Angiotensin-Converting Enzyme in the Male Rat Reproductive System: Autoradiographic Visualization with [3H]Captopril*
STRITTMATTER S, SNYDER S. Angiotensin-Converting Enzyme in the Male Rat Reproductive System: Autoradiographic Visualization with [3H]Captopril*. Endocrinology 1984, 115: 2332-2341. PMID: 6094156, DOI: 10.1210/endo-115-6-2332.Peer-Reviewed Original ResearchConceptsACE activityMale rat reproductive systemRat reproductive systemSoluble ACE activityAutoradiographic silver grainsStages I-VIIIInitial segmentMale ratsAutoradiographic visualizationPharmacological profileTesticular slicesBasal epitheliumSilver grainsLuminal labellingReproductive tractInterstitial tissueMonoclonal antibodiesVas deferensSeminiferous tubulesLevel of bindingReproductive systemLuminal surfaceEpithelium