2019
Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure
Pfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D. Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure. Scientific Reports 2019, 9: 5791. PMID: 30962467, PMCID: PMC6453892, DOI: 10.1038/s41598-019-42113-0.Peer-Reviewed Original ResearchMeSH KeywordsAminobutyratesAngiotensin Receptor AntagonistsAnimalsBiphenyl CompoundsDrug CombinationsHeartHeart FailureMaleMyocardial Reperfusion InjuryMyocardiumNeovascularization, PhysiologicNeprilysinOrganotechnetium CompoundsPeptides, CyclicRatsRats, Inbred LewSingle Photon Emission Computed Tomography Computed TomographyTetrazolesValsartanVascular Endothelial Growth Factor AVentricular RemodelingConceptsSacubitril/valsartanExperimental heart failureHeart failureMyocardial infarctionMyocardial remodelingAngiotensin receptor neprilysin inhibitorAngiotensin receptor blocker valsartanMicroSPECT/CT imagingReceptor blocker valsartanHeart failure patientsProgressive LV dilationGlobal LV functionLV contractile dysfunctionNeprilysin inhibitor sacubitrilBorder zoneLimited remodelingFailure patientsInhibitor therapyMale LewisWeeks treatmentLV dilationLV functionNeprilysin inhibitorContractile dysfunctionInterstitial fibrosisIncisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.
Shah A, Sumpio BJ, Tsay C, Swallow M, Dash B, Thorn SL, Sinusas AJ, Koo A, Hsia HC, Au A. Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study. Annals Of Plastic Surgery 2019, 82: s222-s227. PMID: 30855392, DOI: 10.1097/sap.0000000000001842.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsMaleModels, AnimalNegative-Pressure Wound TherapyNeovascularization, PhysiologicPilot ProjectsRegional Blood FlowSwineWound HealingConceptsNegative pressure wound therapyVascular endothelial growth factorClosed woundsUse of NPWTVEGF expressionSurgical wound sitePressure wound therapyMale Yorkshire pigsEnzyme-linked immunosorbent assay resultsEnzyme-linked immunosorbent assayEndothelial growth factorExcisional wound modelImmunosorbent assay resultsControl dressingsPrimary sutureScar evaluationImmunohistochemistry stainingIncision siteNPWT dressingsWound therapyAngiogenesis markersTreatment groupsAppearance of woundsOpen woundsWound healing model
2014
The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
Ahmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud JM, Manthorp E, Kuraitis D, Toeg H, Mesana TG, Davis DR, Beanlands RS, DaSilva JN, deKemp RA, Ruel M, Suuronen EJ. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 2014, 35: 4749-4758. PMID: 24631247, DOI: 10.1016/j.biomaterials.2014.02.028.Peer-Reviewed Original ResearchConceptsMatrix therapyMouse myocardial infarction modelMyocardial infarction modelCardiac cell therapySynergistic therapeutic effectTherapeutic effectMyocardial perfusionParacrine propertiesInfarcted myocardiumAngiogenic cellsInfarction modelOverall efficacyTherapyCell therapyAngiogenic potentialCACSΑ5 integrinIntegrin α2EngraftmentIntegrin α5PerfusionCellsIntegrinsCollagen matrixCAC function