2009
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus
Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials 2009, 8: 986-992. PMID: 19855383, PMCID: PMC3415301, DOI: 10.1038/nmat2558.Peer-Reviewed Original ResearchConceptsMulti-scale structural hierarchyAnnulus fibrosus tissue engineeringTissue engineering applicationsLoad-bearing tissuesTensile responseEngineering applicationsTissue engineeringLaminatesBiomimetic materialsComplex mechanical functionsNative tissueStructural hierarchySuccessful engineeringEngineeringScaffoldsAnnulus fibrosusGreat interestShearingMechanical functionComplex tissuesDepositionMaterials
2007
Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs
Baker B, O’Connell G, Sen S, Nathan A, Elliott D, Mauck R. Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs. 2007, 1013-1014. DOI: 10.1115/sbc2007-176434.Peer-Reviewed Original ResearchFunctional tissue engineeringLength scalesLaminate structureCompressive loadingMultiple length scalesTensile deformationTensile propertiesCircumferential tensile propertiesTissue engineeringCentimeter length scalesFiber directionTransverse directionRadial tie fibersMechanical environmentKnee meniscusNanoscale interactionsAdjacent layersStructural propertiesCell patterningMechanical functionHorizontal axisAnnulus fibrosusMeniscusDeformationProperties