Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction
Boxberger J, Auerbach J, Sen S, Dodge G, Elliott D. Intervertebral Disc Function Is Restored in an In Vivo Model of Chronic Nucleus Pulposus Glycosaminoglycan Reduction. 2008, 127-128. DOI: 10.1115/sbc2008-192937.Peer-Reviewed Original ResearchWeeks post treatmentDisc degenerationPost treatmentIntervertebral disc degenerationRat lumbar discsLong-term effectsLumbar discVivo modelGAG lossDegenerationEarly lossHallmark featureTerm effectsGAG depletionMechanical functionDetectable changeGagGlycosaminoglycan contentSmall percentageTreatmentLow levelsMechanical changesHuman degenerationElevated stressHypermobilityEffect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension
Sen S, Boxberger J, Schroeder Y, Orias A, Elliott D. Effect of Degeneration on the Dynamic Viscoelastic Properties of Human Annulus Fibrosus in Tension. 2008, 609-610. DOI: 10.1115/sbc2008-193057.Peer-Reviewed Original ResearchDisc degenerationViscoelastic propertiesStructural finite element modelIntervertebral disc degenerationFinite element modelUniaxial tensile testsPhysiological cyclic loadingQuasi-static conditionsHuman AF tissueDynamic viscoelastic propertiesStatic viscoelastic propertiesAF tissueCyclic loadingElement modelTensile testsIntervertebral discMechanical assessmentRegenerative approachesTissueDegenerate tissueMechanical functionDegenerationAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks