2006
Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo
Salvalaggio PR, Camirand G, Ariyan CE, Deng S, Rogozinski L, Basadonna GP, Rothstein DM. Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo. The Journal Of Immunology 2006, 176: 2292-2298. PMID: 16455985, DOI: 10.4049/jimmunol.176.4.2292.Peer-Reviewed Original ResearchConceptsCTLA-4 expressionLong-term engraftmentBALB/cCTLA-4Allograft toleranceCD4 cellsAnti-CD45RB treatmentAcute rejectionCD25 depletionDonor AgUnrelated alloantigensPeritransplant periodAntigen exposureEffector cellsPoor outcomeUnrelated AgAg exposureTransplantationEngraftmentDay 17Day 0Therapeutic enhancementMiceAlloantigensTemporal relationship
2003
Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression
Ariyan C, Salvalaggio P, Fecteau S, Deng S, Rogozinski L, Mandelbrot D, Sharpe A, Sayegh MH, Basadonna GP, Rothstein DM. Cutting Edge: Transplantation Tolerance through Enhanced CTLA-4 Expression. The Journal Of Immunology 2003, 171: 5673-5677. PMID: 14634073, DOI: 10.4049/jimmunol.171.11.5673.Peer-Reviewed Original ResearchMeSH KeywordsAbataceptAdjuvants, ImmunologicAnimalsAntibodies, MonoclonalAntigens, CDAntigens, DifferentiationCTLA-4 AntigenGraft Enhancement, ImmunologicGraft SurvivalImmunoconjugatesInjections, IntraperitonealInjections, IntravenousIslets of Langerhans TransplantationLeukocyte Common AntigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSignal TransductionTransplantation ToleranceUp-RegulationConceptsCTLA-4 expressionCTLA-4Allograft survivalCTLA4-IgAnti-CD45RB therapyIslet allograft survivalCTLA-4 interactionWild-type miceLong-term engraftmentPeripheral toleranceTransplantation toleranceAllogeneic cellsB7-1B7-2Requisite roleEngraftmentMiceB7SurvivalSpecific roleCritical roleExpressionTransplantationTherapyRecipients