2024
Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences
Ku B, Yuan Q, Arias-Magnasco A, Lin B, Walker E, Druss B, Ren J, van Os J, Guloksuz S. Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences. Schizophrenia Bulletin 2024, sbae141. PMID: 39171674, DOI: 10.1093/schbul/sbae141.Peer-Reviewed Original ResearchClassification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts
Visoki E, Moore T, Zhang X, Tran K, Ly C, Gataviņš M, DiDomenico G, Brogan L, Fein J, Warrier V, Guloksuz S, Barzilay R. Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts. JAMA Psychiatry 2024, 81 PMID: 39018056, PMCID: PMC11255979, DOI: 10.1001/jamapsychiatry.2024.1887.Peer-Reviewed Original ResearchMillennium Cohort StudyExposome scoreLifestyle factorsAdolescent Brain Cognitive DevelopmentCohort studyExposome-wide association studyAssociated with suicide attemptsUK Millennium Cohort StudyNational longitudinal cohortSuicide attemptsProtective exposuresLogistic regression modelsFamily history of suicideRisk classificationAdolescent Brain Cognitive Development StudyUS hospitalsEnvironmental/lifestyle factorsEmergency departmentTest associationsHistory of suicidePopulation settingCause of deathUS adolescentsFamily historyLongitudinal cohortThe European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment
Schoretsanitis G, Correll C, Agorastos A, Sanchez A, Erzin G, Grigoras R, Benussi M, Gondek T, Guloksuz S, Højlund M, Jerotic S, Kilic O, Metaj E, Sidhu D, Skandali N, Skuhareuski A, Tveito M, Wolthusen R, Communication and Publications E, Chumakov E, de Filippis R. The European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment. The World Journal Of Biological Psychiatry 2024, 25: 342-351. PMID: 38905131, DOI: 10.1080/15622975.2024.2367138.Peer-Reviewed Original ResearchConceptsEuropean Psychiatric AssociationAntipsychotic treatmentPsychiatrists' attitudesTherapeutic drug monitoringEarly-career psychiatristsExploratory factor analysisBenefit of therapeutic drug monitoringPsychiatric AssociationAntipsychoticsNegative expectationsAssociated with frequencyTDM useDrug monitoringTherapeutic drug monitoring useFactor analysisBeliefs of patientsHigh-income countriesLow-/middle-income countriesResponse varianceClinical benefitClozapineOutpatient settingLinear regression analysisClinical settingPsychiatristsThe relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study.
Üçok A, Noyan H, Gülöksüz S, Saka M, Alptekin K, Atbaşoğlu C, Akturan E, Karadayı G, Baran Tatar Z, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Şahin Cankurtaran E, Ulusoy Kaymak S, Rutten B, van Os J. The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study. Psychological Medicine 2024, 1-12. PMID: 38606591, DOI: 10.1017/s0033291724000540.Peer-Reviewed Original ResearchNegative cognitive schemasChildhood traumaCognitive schemasPsychotic symptomsEU-GEIEmotional abuseBrief Core Schema ScalesEU-GEI studySubthreshold psychotic experiencesSubtypes of traumaChildhood emotional abuseChildhood Trauma QuestionnaireNon-clinical populationsHealthy controlsNegative schemasPositive symptomsPersecutory delusionsPsychotic experiencesSchema ScaleTrauma QuestionnaireChildhood abuseSymptom severitySchizophreniaSexual abuseAbuseThe why and the how of transdiagnostic clinical research in youth psychiatry
Díaz-Caneja C, Guloksuz S. The why and the how of transdiagnostic clinical research in youth psychiatry. European Neuropsychopharmacology 2024, 82: 55-56. PMID: 38490086, DOI: 10.1016/j.euroneuro.2024.02.012.Peer-Reviewed Original ResearchCorrection: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. Correction: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1567-1567. PMID: 38351175, DOI: 10.1038/s41380-024-02481-0.Peer-Reviewed Original ResearchOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINEPopulation Salutogenesis—The Future of Psychiatry?
van Os J, Guloksuz S. Population Salutogenesis—The Future of Psychiatry? JAMA Psychiatry 2024, 81: 115-116. PMID: 38117509, DOI: 10.1001/jamapsychiatry.2023.4582.Peer-Reviewed Original ResearchDissecting causal relationships between cortical morphology and neuropsychiatric disorders
Goula A, Lin B, Li Y, Chang X, Grasby K, Medland S, Andreassen O, Rutten B, Guloksuz S, Van der Meer D, Luykx J. Dissecting causal relationships between cortical morphology and neuropsychiatric disorders. Neuroscience Applied 2024, 3: 103960. DOI: 10.1016/j.nsa.2024.103960.Peer-Reviewed Original Research
2023
“It has to be better, otherwise we will get stuck.” A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands
van Os J, Scheepers F, Milo M, Ockeloen G, Guloksuz S, Delespaul P. “It has to be better, otherwise we will get stuck.” A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands. Clinical Practice And Epidemiology In Mental Health 2023, 19: e17450179271206. PMID: 38680529, PMCID: PMC11046893, DOI: 10.2174/0117450179271206231114064736.Peer-Reviewed Original ResearchMental health careHealth careEnhance public mental healthDutch mental health care systemMental health care servicesMental health care systemIntegrated public health approachHigh-quality careMental health reformHealth care consumptionHealth care servicesPublic health approachHealth care systemMental health problemsSmall area indicatorsPublic mental healthSocial care organizationsPopulation-based approachGroup-based treatmentEcosystem of careRecovery CollegesEmpower patientsCare servicesHealthcare providersCare consumptionT15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS
Zhang Y, Gülöksüz S, Stehouwer C, Greevenbroek M, Köhler S, Eussen S, Bosma H, Boxtel M, Schram M, Linden D, Rutten B, Blokland G. T15. THE ADDITIVE VALUE OF BRAIN LIFESTYLE IN THE EXPLANATORY ABILITY OF POLYGENIC RISK PROFILES ON COGNITIVE PERFORMANCE IN AGING INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s169-s170. DOI: 10.1016/j.euroneuro.2023.08.303.Peer-Reviewed Original ResearchPolygenic risk scoresCognitive domainsCognitive functionHeritability of cognitive functionsEffect of polygenic risk scoresEnvironmental influencesThe Maastricht StudyPotential cognitive deficitsOverall cognitive functionBrain health indexImpact cognitive healthRisk factorsGenetic predispositionGene-environment interactionsCardio-metabolic diseasesLIBRA scoresNon-adjusted modelCognitive phenotypesCognitive deficitsCognitive performanceCognitive healthLifestyle factorsOverall cognitionBrain structuresMental healthAddressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium
Koops S, Allott K, de Haan L, Chen E, Hui C, Killackey E, Long M, Moncrieff J, Sommer I, Stürup A, Wunderink L, Begemann M, van der A J, Bakker P, Beer F, Begemann M, van Beveren N, Boonstra T, Brand B, Djordjevic M, Franke S, Gangadin S, Guloksuz S, Haan L, van ‘t Hag G, Hamers I, van der Heijden-Hobus I, Hoornaar R, Huizer K, Kikkert M, Koops S, Lokkerbol J, Marcelis M, Oomen P, van Os J, Rosema B, Sommer I, Smit F, Veling W, Voppel A, Albert N, Karlsen M, Nordentoft M, Speyer H, Stürup A, Allott K, Killackey E, O’Donoghue B, Stainton A, Cooper R, Conneely M, Grünwald L, Haynes N, Horowitz M, Mason J, Long M, Moncrieff J, Priebe S, Stansfeld J, Vasiliki G, Chen E, Hui C, Wunderink L, Liu C, Berna F, Foucher J. Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium. Schizophrenia Bulletin 2023, 50: 5-8. PMID: 37625022, PMCID: PMC10754158, DOI: 10.1093/schbul/sbad112.Peer-Reviewed Original ResearchThe association between autistic traits and quality of social interactions in the daily life of adolescents and young adults
Fusar-Poli L, Investigators T, van Os J, Rutten B, Guloksuz S. The association between autistic traits and quality of social interactions in the daily life of adolescents and young adults. European Psychiatry 2023, 66: s76-s76. PMCID: PMC10596031, DOI: 10.1192/j.eurpsy.2023.246.Peer-Reviewed Original ResearchHigh autistic traitsAutism Spectrum QuotientAutistic traitsAutism spectrum disorderSocial interactionLow senseExperience sampling periodEveryday social interactionsNon-autistic subjectsDisclosure of interestDaily lifePsychosocial interventionsSpectrum disorderRepetitive behaviorsSocial communicationSocial functioningNeurodevelopmental conditionsHigh senseYoung adultsYouthParticipantsTraitsGeneral populationSenseHigher preferenceAssociations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia
Lin B, Pinzón-Espinosa J, Blouzard E, van der Horst M, Okhuijsen-Pfeifer C, van Eijk K, Guloksuz S, Peyrot W, Luykx J, Hasan A, Wagner E, Pantelis C, Everall I, Ayhan Y, Babaoğlu M, Bak M, Alink W, Beld E, Bouhuis A, Edlinger M, Erdoğan I, Gutwinski S, Hallikainen T, Jeger-land E, Lähteenvuo M, de Koning M, Morgenroth C, Müderrisoğlu A, Oviedo-Salcedo T, Schreiter S, Repo-Tiihonen E, Tuppurainen H, Veereschild M, Veerman S, de Vos M, Cohen D, Bogers J, Anıl Yağcıoğlu A, Tiihonen J, Ripke S, Bousman C, Van Beek H, Okhuijsen-Pfeifer C, van der Horst M, van Eijk K, Ertuğrul A, Yoca G, Görlitz T, Grootens K, Leucht S, Narang A, Schneider-Thoma J, Kahn R, Bekema E, Kleymann P, Luykx J, Alizadeh B, van Amelsvoort T, Cahn W, de Haan L, Schirmbeck F, Simons C, van Os J, Rutten B, van Winkel R. Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia. JAMA Psychiatry 2023, 80: 181-185. PMID: 36542388, PMCID: PMC9857760, DOI: 10.1001/jamapsychiatry.2022.4234.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersRisk ratioPolygenic risk scoresUnrelated healthy controlsRisk scorePRS-SCZClozapine useHealthy controlsOdds ratioCourse of illnessHigher likelihoodPsychosis liabilityClozapine prescribingClozapine prescriptionPharmacotherapy choicesClozapine treatmentObservational cohortMedication useAntipsychotic useAntipsychotic treatmentMAIN OUTCOMEMultinomial logistic regressionPrognostic studiesAntipsychoticsEarly interventionCoping and sleep quality in youth: An Experience Sampling study
Hagemann N, Kirtley O, Lafit G, Vancampfort D, Wampers M, Decoster J, Derom C, Gülöksüz S, De Hert M, Jacobs N, Menne‐Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin‐Germeys I. Coping and sleep quality in youth: An Experience Sampling study. Journal Of Adolescence 2023, 95: 566-583. PMID: 36647754, DOI: 10.1002/jad.12137.Peer-Reviewed Original ResearchConceptsEmotion-focused copingExperience Sampling StudySleep qualityDaily sleep qualitySample of youthLocus of controlSampling studyUtrecht Coping ListPassive reactionNegative eventsDaily lifeFuture insomniaCopingSleep problemsQuality of sleepMental wellMental healthDisengagementYouthState locusIndividual presentStyleDecreased sleep qualitySleepPsychopathologyLongitudinal effects of genomic and exposomic vulnerability for schizophrenia on childhood psychosis expression: results from the ABCD Study
Di Vincenzo M, Prachason T, Sampogna G, Arias-Magnasco A, Lin B, Pries L, Van Os J, Rutten B, Guloksuz S. Longitudinal effects of genomic and exposomic vulnerability for schizophrenia on childhood psychosis expression: results from the ABCD Study. Neuroscience Applied 2023, 2: 102518. DOI: 10.1016/j.nsa.2023.102518.Peer-Reviewed Original ResearchThe association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls
Erzin G, Atbaşoğlu C, Fusar-Poli L, Saka M, Üçok A, Alptekin K, Van Os J, Guloksuz S, Gümüş-Akay G. The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls. Neuroscience Applied 2023, 2: 103594. DOI: 10.1016/j.nsa.2023.103594.Peer-Reviewed Original Research
2022
Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm
Cavaliere F, Gülöksüz S. Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigm. Npj Mental Health Research 2022, 1: 20. PMID: 38609523, PMCID: PMC10956007, DOI: 10.1038/s44184-022-00018-3.Peer-Reviewed Original ResearchThe relationship between daily positive future thinking and past-week suicidal ideation in youth: An experience sampling study
Kirtley O, Lafit G, Vaessen T, Decoster J, Derom C, Gülöksüz S, De Hert M, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I. The relationship between daily positive future thinking and past-week suicidal ideation in youth: An experience sampling study. Frontiers In Psychiatry 2022, 13: 915007. PMID: 36245862, PMCID: PMC9556869, DOI: 10.3389/fpsyt.2022.915007.Peer-Reviewed Original ResearchPositive future thinkingExperience sampling methodPast-week suicidal ideationFuture thinkingNegative affectSuicidal ideationAverage negative affectAverage positive affectNon-clinical sampleRole of affectLab-based assessmentSelf-report questionnairesNon-twin siblingsPositive affectAdolescent twinsCommunity sampleAffectMixed-effects linear regression modelsSCL-90Prior researchYouthFuture researchBidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther support