2024
The European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment
Schoretsanitis G, Correll C, Agorastos A, Sanchez A, Erzin G, Grigoras R, Benussi M, Gondek T, Guloksuz S, Højlund M, Jerotic S, Kilic O, Metaj E, Sidhu D, Skandali N, Skuhareuski A, Tveito M, Wolthusen R, Communication and Publications E, Chumakov E, de Filippis R. The European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment. The World Journal Of Biological Psychiatry 2024, 25: 342-351. PMID: 38905131, DOI: 10.1080/15622975.2024.2367138.Peer-Reviewed Original ResearchConceptsEuropean Psychiatric AssociationAntipsychotic treatmentPsychiatrists' attitudesTherapeutic drug monitoringEarly-career psychiatristsExploratory factor analysisBenefit of therapeutic drug monitoringPsychiatric AssociationAntipsychoticsNegative expectationsAssociated with frequencyTDM useDrug monitoringTherapeutic drug monitoring useFactor analysisBeliefs of patientsHigh-income countriesLow-/middle-income countriesResponse varianceClinical benefitClozapineOutpatient settingLinear regression analysisClinical settingPsychiatrists
2023
Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium
Koops S, Allott K, de Haan L, Chen E, Hui C, Killackey E, Long M, Moncrieff J, Sommer I, Stürup A, Wunderink L, Begemann M, van der A J, Bakker P, Beer F, Begemann M, van Beveren N, Boonstra T, Brand B, Djordjevic M, Franke S, Gangadin S, Guloksuz S, Haan L, van ‘t Hag G, Hamers I, van der Heijden-Hobus I, Hoornaar R, Huizer K, Kikkert M, Koops S, Lokkerbol J, Marcelis M, Oomen P, van Os J, Rosema B, Sommer I, Smit F, Veling W, Voppel A, Albert N, Karlsen M, Nordentoft M, Speyer H, Stürup A, Allott K, Killackey E, O’Donoghue B, Stainton A, Cooper R, Conneely M, Grünwald L, Haynes N, Horowitz M, Mason J, Long M, Moncrieff J, Priebe S, Stansfeld J, Vasiliki G, Chen E, Hui C, Wunderink L, Liu C, Berna F, Foucher J. Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium. Schizophrenia Bulletin 2023, 50: 5-8. PMID: 37625022, PMCID: PMC10754158, DOI: 10.1093/schbul/sbad112.Peer-Reviewed Original ResearchAssociations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia
Lin B, Pinzón-Espinosa J, Blouzard E, van der Horst M, Okhuijsen-Pfeifer C, van Eijk K, Guloksuz S, Peyrot W, Luykx J, Hasan A, Wagner E, Pantelis C, Everall I, Ayhan Y, Babaoğlu M, Bak M, Alink W, Beld E, Bouhuis A, Edlinger M, Erdoğan I, Gutwinski S, Hallikainen T, Jeger-land E, Lähteenvuo M, de Koning M, Morgenroth C, Müderrisoğlu A, Oviedo-Salcedo T, Schreiter S, Repo-Tiihonen E, Tuppurainen H, Veereschild M, Veerman S, de Vos M, Cohen D, Bogers J, Anıl Yağcıoğlu A, Tiihonen J, Ripke S, Bousman C, Van Beek H, Okhuijsen-Pfeifer C, van der Horst M, van Eijk K, Ertuğrul A, Yoca G, Görlitz T, Grootens K, Leucht S, Narang A, Schneider-Thoma J, Kahn R, Bekema E, Kleymann P, Luykx J, Alizadeh B, van Amelsvoort T, Cahn W, de Haan L, Schirmbeck F, Simons C, van Os J, Rutten B, van Winkel R. Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia. JAMA Psychiatry 2023, 80: 181-185. PMID: 36542388, PMCID: PMC9857760, DOI: 10.1001/jamapsychiatry.2022.4234.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersRisk ratioPolygenic risk scoresUnrelated healthy controlsRisk scorePRS-SCZClozapine useHealthy controlsOdds ratioCourse of illnessHigher likelihoodPsychosis liabilityClozapine prescribingClozapine prescriptionPharmacotherapy choicesClozapine treatmentObservational cohortMedication useAntipsychotic useAntipsychotic treatmentMAIN OUTCOMEMultinomial logistic regressionPrognostic studiesAntipsychoticsEarly interventionCoping and sleep quality in youth: An Experience Sampling study
Hagemann N, Kirtley O, Lafit G, Vancampfort D, Wampers M, Decoster J, Derom C, Gülöksüz S, De Hert M, Jacobs N, Menne‐Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin‐Germeys I. Coping and sleep quality in youth: An Experience Sampling study. Journal Of Adolescence 2023, 95: 566-583. PMID: 36647754, DOI: 10.1002/jad.12137.Peer-Reviewed Original ResearchConceptsEmotion-focused copingExperience Sampling StudySleep qualityDaily sleep qualitySample of youthLocus of controlSampling studyUtrecht Coping ListPassive reactionNegative eventsDaily lifeFuture insomniaCopingSleep problemsQuality of sleepMental wellMental healthDisengagementYouthState locusIndividual presentStyleDecreased sleep qualitySleepPsychopathology
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportLongitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy
Schurgers G, Walter S, Pishva E, Guloksuz S, Peerbooms O, Incio L, Arts B, Kenis G, Rutten B. Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy. European Neuropsychopharmacology 2022, 63: 60-70. PMID: 36067540, DOI: 10.1016/j.euroneuro.2022.07.183.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF/TrkBExpression of BDNFSerum BDNF protein levelsBDNF protein levelsElectroconvulsive therapyDepression scoresMRNA expressionPeripheral bloodTreatment-resistant depressed patientsProtein levelsMechanism of actionAntidepressant effectsNeurotrophic factorDepressed patientsLongitudinal alterationsSevere depressionBlood correlatesEffective treatmentLongitudinal changesTrkBStudy periodNR3C1PatientsTherapyNongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants
Lin B, Pries L, Sarac H, van Os J, Rutten B, Luykx J, Guloksuz S. Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants. JAMA Psychiatry 2022, 79: 857-868. PMID: 35857297, PMCID: PMC9301596, DOI: 10.1001/jamapsychiatry.2022.1655.Peer-Reviewed Original ResearchThe association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Fusar-Poli L, Pries LK, van Os J, Radhakrishnan R, Pençe AY, Erzin G, Delespaul P, Kenis G, Luykx JJ, Lin BD, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran EŞ, Kaymak SU, Mihaljevic MM, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz PA, García-Portilla MP, Sanjuan J, Aguilar EJ, Santos JL, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric NP, Atbaşoğlu C, Üçok A, Alptekin K, Saka MC, investigators G, Aguglia E, Arango C, Rutten BP, Guloksuz S. The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. European Neuropsychopharmacology 2022, 63: 47-59. PMID: 36055075, DOI: 10.1016/j.euroneuro.2022.08.003.Peer-Reviewed Original ResearchConceptsHealthy controlsCannabis useDegraded Facial Affect Recognition TaskPresent cross-sectional studyCross-sectional studyHigh genetic riskProgression of schizophreniaRegular cannabis useCognitive disturbancesRegular cannabisPsychosis riskPatientsSchizophreniaFacial emotion recognition performanceGenetic riskCannabisCurrent cannabisEUGEI studyLongitudinal studyAgeSiblingsAssociationRiskOnsetEffect relationshipAge- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population
Paquin V, Pries L, ten Have M, Bak M, Gunther N, de Graaf R, van Dorsselaer S, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, van Os J, Shah J, Guloksuz S. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry And Psychiatric Epidemiology 2022, 58: 43-52. PMID: 35913550, PMCID: PMC9845157, DOI: 10.1007/s00127-022-02346-3.Peer-Reviewed Original ResearchConceptsSex-specific associationsSelf-reported healthPRS-SCZES-SCZPhysical healthGeneral populationNetherlands Mental Health SurveyIncidence Study-2Mental Health SurveyHealth SurveyRisk scoreAge 65Common genetic variantsHealth correlatesAge 18Poor healthOlder individualsMental healthPolygenic riskLinear mixed modelsAgeSexExposome scoreHealthAssociationPolygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype?
Fusar-Poli L, Rutten B, van Os J, Aguglia E, Guloksuz S. Polygenic risk scores for predicting outcomes and treatment response in psychiatry: hope or hype? International Review Of Psychiatry 2022, 34: 663-675. PMID: 36786114, DOI: 10.1080/09540261.2022.2101352.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresTreatment responseRisk scoreMental disordersDetailed clinical characterizationPresent narrative reviewPotential clinical utilityMajor mental disordersIndividual genetic predispositionRisk stratificationPrognostic evaluationClinical characterizationWide association study datasetsClinical utilityGeneral populationGenetic predispositionNarrative reviewSingle nucleotide polymorphismsReducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative
Ferrara M, Gallagher K, Yoviene Sykes LA, Markovich P, Li F, Pollard JM, Imetovski S, Cahill J, Guloksuz S, Srihari VH. Reducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative. Psychiatric Services 2022, 73: 1416-1419. PMID: 35652190, PMCID: PMC9715806, DOI: 10.1176/appi.ps.202100374.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesConfirmation of eligibilityEarly detection campaignsProportion of admissionsSpecialty care servicesQuality improvement interventionsQuality improvement initiativesLonger DUPMedian delayPoor outcomeUntreated psychosisTreatment accessPsychosis onsetPsychosis servicesCSC servicesCare servicesImprovement interventionsAdmissionImprovement initiativesDetection campaignsInterventionGreater vulnerabilityReferralPsychosisEarly intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis
Shah J, Jones N, van Os J, McGorry P, Gülöksüz S. Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. The Lancet Psychiatry 2022, 9: 413-422. PMID: 35430004, DOI: 10.1016/s2215-0366(21)00467-3.Peer-Reviewed Original ResearchConceptsRisk mental stateBroader mental health systemNon-psychotic disordersPerson-centred careMental health systemYouth mental healthClinical stagingEarly intervention service systemFirst episodeRelevance of outcomesEarly psychosisCenters of expertiseFrequent developmentDifferential riskClinical researchHealth systemPsychosisSpecific interventionsMental healthSyndromeMental statesDisordersTraditional diagnosisOutcomesClinicGeneral psychopathology and its social correlates in the daily lives of youth
Achterhof R, Kirtley O, Schneider M, Hagemann N, Hermans K, Hiekkaranta A, Lecei A, Decoster J, Derom C, De Hert M, Gülöksüz S, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I. General psychopathology and its social correlates in the daily lives of youth. Journal Of Affective Disorders 2022, 309: 428-436. PMID: 35500686, DOI: 10.1016/j.jad.2022.04.147.Peer-Reviewed Original ResearchMapping genomic loci implicates genes and synaptic biology in schizophrenia
Trubetskoy V, Pardiñas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, Bryois J, Chen C, Dennison C, Hall L, Lam M, Watanabe K, Frei O, Ge T, Harwood J, Koopmans F, Magnusson S, Richards A, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson E, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh B, Alptekin K, Als T, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo M, Bacanu S, Bass N, Begemann M, Belliveau R, Bene J, Benyamin B, Bergen S, Blasi G, Bobes J, Bonassi S, Braun A, Bressan R, Bromet E, Bruggeman R, Buckley P, Buckner R, Bybjerg-Grauholm J, Cahn W, Cairns M, Calkins M, Carr V, Castle D, Catts S, Chambert K, Chan R, Chaumette B, Cheng W, Cheung E, Chong S, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis K, de Haan L, Degenhardt F, DeLisi L, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson J, Fañanás L, Faraone S, Fiorentino A, Forstner A, Frank J, Freimer N, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon E, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein J, González Peñas J, González-Pinto A, Gopal S, Gratten J, Green M, Greenwood T, Guillin O, Gülöksüz S, Gur R, Gur R, Gutiérrez B, Hahn E, Hakonarson H, Haroutunian V, Hartmann A, Harvey C, Hayward C, Henskens F, Herms S, Hoffmann P, Howrigan D, Ikeda M, Iyegbe C, Joa I, Julià A, Kähler A, Kam-Thong T, Kamatani Y, Karachanak-Yankova S, Kebir O, Keller M, Kelly B, Khrunin A, Kim S, Klovins J, Kondratiev N, Konte B, Kraft J, Kubo M, Kučinskas V, Kučinskiene Z, Kusumawardhani A, Kuzelova-Ptackova H, Landi S, Lazzeroni L, Lee P, Legge S, Lehrer D, Lencer R, Lerer B, Li M, Lieberman J, Light G, Limborska S, Liu C, Lönnqvist J, Loughland C, Lubinski J, Luykx J, Lynham A, Macek M, Mackinnon A, Magnusson P, Maher B, Maier W, Malaspina D, Mallet J, Marder S, Marsal S, Martin A, Martorell L, Mattheisen M, McCarley R, McDonald C, McGrath J, Medeiros H, Meier S, Melegh B, Melle I, Mesholam-Gately R, Metspalu A, Michie P, Milani L, Milanova V, Mitjans M, Molden E, Molina E, Molto M, Mondelli V, Moreno C, Morley C, Muntané G, Murphy K, Myin-Germeys I, Nenadić I, Nestadt G, Nikitina-Zake L, Noto C, Nuechterlein K, O’Brien N, O’Neill F, Oh S, Olincy A, Ota V, Pantelis C, Papadimitriou G, Parellada M, Paunio T, Pellegrino R, Periyasamy S, Perkins D, Pfuhlmann B, Pietiläinen O, Pimm J, Porteous D, Powell J, Quattrone D, Quested D, Radant A, Rampino A, Rapaport M, Rautanen A, Reichenberg A, Roe C, Roffman J, Roth J, Rothermundt M, Rutten B, Saker-Delye S, Salomaa V, Sanjuan J, Santoro M, Savitz A, Schall U, Scott R, Seidman L, Sharp S, Shi J, Siever L, Sigurdsson E, Sim K, Skarabis N, Slominsky P, So H, Sobell J, Söderman E, Stain H, Steen N, Steixner-Kumar A, Stögmann E, Stone W, Straub R, Streit F, Strengman E, Stroup T, Subramaniam M, Sugar C, Suvisaari J, Svrakic D, Swerdlow N, Szatkiewicz J, Ta T, Takahashi A, Terao C, Thibaut F, Toncheva D, Tooney P, Torretta S, Tosato S, Tura G, Turetsky B, Üçok A, Vaaler A, van Amelsvoort T, van Winkel R, Veijola J, Waddington J, Walter H, Waterreus A, Webb B, Weiser M, Williams N, Witt S, Wormley B, Wu J, Xu Z, Yolken R, Zai C, Zhou W, Zhu F, Zimprich F, Atbaşoğlu E, Ayub M, Benner C, Bertolino A, Black D, Bray N, Breen G, Buccola N, Byerley W, Chen W, Cloninger C, Crespo-Facorro B, Donohoe G, Freedman R, Galletly C, Gandal M, Gennarelli M, Hougaard D, Hwu H, Jablensky A, McCarroll S, Moran J, Mors O, Mortensen P, Müller-Myhsok B, Neil A, Nordentoft M, Pato M, Petryshen T, Pirinen M, Pulver A, Schulze T, Silverman J, Smoller J, Stahl E, Tsuang D, Vilella E, Wang S, Xu S, Adolfsson R, Arango C, Baune B, Belangero S, Børglum A, Braff D, Bramon E, Buxbaum J, Campion D, Cervilla J, Cichon S, Collier D, Corvin A, Curtis D, Forti M, Domenici E, Ehrenreich H, Escott-Price V, Esko T, Fanous A, Gareeva A, Gawlik M, Gejman P, Gill M, Glatt S, Golimbet V, Hong K, Hultman C, Hyman S, Iwata N, Jönsson E, Kahn R, Kennedy J, Khusnutdinova E, Kirov G, Knowles J, Krebs M, Laurent-Levinson C, Lee J, Lencz T, Levinson D, Li Q, Liu J, Malhotra A, Malhotra D, McIntosh A, McQuillin A, Menezes P, Morgan V, Morris D, Mowry B, Murray R, Nimgaonkar V, Nöthen M, Ophoff R, Paciga S, Palotie A, Pato C, Qin S, Rietschel M, Riley B, Rivera M, Rujescu D, Saka M, Sanders A, Schwab S, Serretti A, Sham P, Shi Y, St Clair D, Stefánsson H, Stefansson K, Tsuang M, van Os J, Vawter M, Weinberger D, Werge T, Wildenauer D, Yu X, Yue W, Holmans P, Pocklington A, Roussos P, Vassos E, Verhage M, Visscher P, Yang J, Posthuma D, Andreassen O, Kendler K, Owen M, Wray N, Daly M, Huang H, Neale B, Sullivan P, Ripke S, Walters J, O’Donovan M. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022, 604: 502-508. PMID: 35396580, PMCID: PMC9392466, DOI: 10.1038/s41586-022-04434-5.Peer-Reviewed Original ResearchConceptsGenomic lociTwo-stage genome-wide association studyVariant associationsDistinct genomic lociGenome-wide association studiesTranscription factor Sp4Functional genomics dataCommon variant associationsRare variant associationsCommon risk allelesSynaptic biologyGenomic dataBiological processesAssociation studiesGenesCell typesNeurodevelopmental disordersRegion variationLociFundamental processesNeuronal functionSuch variantsRisk allelesMechanistic studiesVariantsBe(com)ing Social: Daily-Life Social Interactions and Parental Bonding
Achterhof R, Schneider M, Kirtley O, Wampers M, Decoster J, Derom C, De Hert M, Guloksuz S, Jacobs N, Menne-Lothmann C, Rutten B, Thiery E, van Os J, van Winkel R, Wichers M, Myin-Germeys I. Be(com)ing Social: Daily-Life Social Interactions and Parental Bonding. Developmental Psychology 2022, 58: 792-805. PMID: 35343722, DOI: 10.1037/dev0001315.Peer-Reviewed Original ResearchConceptsParental Bonding InstrumentSocial interactionSocial experienceExperience sampling periodChildren's social developmentPositive social experiencesThree-factor structureMore social behaviorSocial developmentYoung adult twinsPsychological autonomyDaily lifeSocial functioningSocial dysfunctionParental bondingSocial behaviorBehavioral freedomSocial worldNontwin siblingsAdult twinsSocial independenceFactor analysisStyle of careSocializationStyleGender differences in the association between environment and psychosis
Pence AY, Pries LK, Ferrara M, Rutten BPF, van Os J, Guloksuz S. Gender differences in the association between environment and psychosis. Schizophrenia Research 2022, 243: 120-137. PMID: 35287098, DOI: 10.1016/j.schres.2022.02.039.Peer-Reviewed Original ResearchConceptsGender-related differencesChildhood adversityPsychosis riskSubstance useSubstance abuse comorbidityEnvironmental exposuresOnset of illnessAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthPsychosis spectrum disordersHigh prevalencePsychotic disordersPubMed databaseSystematic reviewPsychosisWomenChildhood abuseSymptom dimensionsMenEarly ageAssociationPsychosis expressionFurther investigationSchizophrenia as a symptom of psychiatry’s reluctance to enter the moral era of medicine
van Os J, Guloksuz S. Schizophrenia as a symptom of psychiatry’s reluctance to enter the moral era of medicine. Schizophrenia Research 2022, 242: 138-140. PMID: 34991949, DOI: 10.1016/j.schres.2021.12.017.Peer-Reviewed Original ResearchInterplay between genetic background and environmental factors in psychiatry: current situation and future prospects.
Rutten B, Guloksuz S, Boks M, van Os J, Luykx J, van Winkel R. Interplay between genetic background and environmental factors in psychiatry: current situation and future prospects. Tijdschrift Voor Psychiatrie 2022, 64: 317-322. PMID: 35735044.Peer-Reviewed Original Research
2021
Immunomodifying and neuroprotective effects of noscapine: Implications for multiple sclerosis, neurodegenerative, and psychiatric disorders
Altinoz M, Guloksuz S, Ozpinar A. Immunomodifying and neuroprotective effects of noscapine: Implications for multiple sclerosis, neurodegenerative, and psychiatric disorders. Chemico-Biological Interactions 2021, 352: 109794. PMID: 34963564, DOI: 10.1016/j.cbi.2021.109794.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyotrophic Lateral SclerosisAnimalsBradykininHistamine AntagonistsHumansImmunomodulating AgentsIon ChannelsMental DisordersMultiple SclerosisNeurodegenerative DiseasesNeuroprotective AgentsNoscapineOligodendrogliaParkinsonian DisordersReceptors, G-Protein-CoupledSignal TransductionStrokeConceptsNeuroprotective effectsMultiple sclerosisInflammatory transcription factor NF-κBIschemic brain damageNeonatal rat pupsPilot clinical studyAmyotrophic lateral sclerosisTranscription factor NF-κBCortical neuronal cellsSignificant therapeutic efficacyFactor NF-κBBitter taste receptorsHistaminergic systemBrain damageRat pupsClinical studiesSK channelsLateral sclerosisParkinson's diseaseAnxiolytic activityPsychiatric disordersChemical injuryNF-κBAnimal modelsPsychiatric diseasesGenetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status
Pasman J, Demange P, Guloksuz S, Willemsen A, Abdellaoui A, ten Have M, Hottenga J, Boomsma D, de Geus E, Bartels M, de Graaf R, Verweij K, Smit D, Nivard M, Vink J. Genetic Risk for Smoking: Disentangling Interplay Between Genes and Socioeconomic Status. Behavior Genetics 2021, 52: 92-107. PMID: 34855049, PMCID: PMC8860781, DOI: 10.1007/s10519-021-10094-4.Peer-Reviewed Original ResearchConceptsLifetime smokingSocioeconomic statusNetherlands Mental Health SurveyMental healthIncidence Study-2Mental Health SurveyNeighborhood socioeconomic statusGenome-wide association studiesGenetic liabilityHealth SurveySmokingGene-environment interactionsEducational attainmentEA effectNetherlands Twin RegisterSmoking traitsGenetic riskPolygenic scoresEtiology of smokingPredictive profilesTwin RegisterSES characteristicsUK BiobankReliable predictorHealth