Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 2020, 52: 1910-1922. PMID: 33070791, DOI: 10.1017/s0033291720003748.Peer-Reviewed Original ResearchMeSH KeywordsDelusionsHallucinationsHumansMultifactorial InheritancePsychotic DisordersRiskSchizophreniaConceptsSchizophrenia spectrum disordersChildhood adversityRisk factorsNEMESIS-2Affective dysregulationNon-genetic risk factorsSignificant depressive symptomsSample of patientsRepresentative general population sampleGenetic risk factorsGeneral population sampleSchizophrenia polygenic riskPsychosis outcomesSpectrum disorderDepressive symptomsPRS-SZPolygenic riskDysregulationPatientsPopulation samplePsychosisAffective pathwayDisordersHallucinatory experiencesDelusional ideationA replication study of JTC bias, genetic liability for psychosis and delusional ideation
Henquet C, van Os J, Pries L, Rauschenberg C, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Gülöksüz S. A replication study of JTC bias, genetic liability for psychosis and delusional ideation. Psychological Medicine 2020, 52: 1777-1783. PMID: 33046166, PMCID: PMC9280279, DOI: 10.1017/s0033291720003578.Peer-Reviewed Original ResearchEvidence for an interrelated cluster of Hallucinatory experiences in the general population: an incidence study
Moriyama T, Drukker M, Guloksuz S, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, van Os J. Evidence for an interrelated cluster of Hallucinatory experiences in the general population: an incidence study. Psychological Medicine 2020, 51: 2034-2043. PMID: 32317030, DOI: 10.1017/s0033291720000793.Peer-Reviewed Original ResearchConceptsRisk factorsProspective general population cohortGeneral population cohortIncidence of hallucinationsNon-psychotic disordersEnvironmental risk factorsTerms of prevalenceSelf-reported ratesYearly incidenceOlfactory hallucinationsVisual hallucinationsFunctional impairmentNEMESIS-2General populationPsychotic disordersHallucinatory experiencesPopulation cohortIncidence studyAuditory hallucinationsDelusional ideationCommon underlying mechanismMental disordersIncidenceNEMESIS-1Subsequent course