2021
Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Gunther N, Luykx J, Rutten B, Guloksuz S. Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis. Psychological Medicine 2021, 53: 1825-1833. PMID: 37310330, PMCID: PMC10106290, DOI: 10.1017/s0033291721003445.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnxietyAnxiety DisordersDiagnostic and Statistical Manual of Mental DisordersHumansProspective StudiesConceptsClinical characterizationPolygenic risk scoresClinical valueProspective general population cohortGeneral population cohortUse of medicationsPopulation attributable fractionPrediction of needDSM-IV diagnosisHealth care outcomesSymptom dimensionsTransdiagnostic frameworkClinical factorsAttributable fractionEtiological factorsRisk scoreCare outcomesCategorical algorithmService usePopulation cohortSociodemographic factorsTransdiagnostic symptom dimensionsPhysical healthDiagnosisDSM diagnoses
2016
Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network
Guloksuz S, van Nierop M, Bak M, de Graaf R, ten Have M, van Dorsselaer S, Gunther N, Lieb R, van Winkel R, Wittchen H, van Os J. Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network. BMC Psychiatry 2016, 16: 223. PMID: 27391407, PMCID: PMC4939022, DOI: 10.1186/s12888-016-0935-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDiagnostic and Statistical Manual of Mental DisordersFemaleHealth SurveysHumansIncidenceMaleMental DisordersNetherlandsRisk FactorsSocial EnvironmentSubstance-Related DisordersSymptom AssessmentYoung AdultConceptsMental disordersSymptom dimensionsNetherlands Mental Health SurveyNEMESIS-1Symptom connectivityContinuous symptom dimensionsEnvironmental exposuresSelf-report Symptom Checklist-90Mental Health SurveySymptom Checklist-90Health SurveyPsychotic symptomsIncidence studyPopulation cohortSelf-reported psychopathologyConclusionsOur findingsDiagnostic categoriesSymptom domainsIndependent population cohortsRisk loadPsychopathology StudyDisordersRegression analysisCohortSymptoms
2015
Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology
Guloksuz S, van Nierop M, Lieb R, van Winkel R, Wittchen H, van Os J. Evidence that the presence of psychosis in non-psychotic disorder is environment-dependent and mediated by severity of non-psychotic psychopathology. Psychological Medicine 2015, 45: 2389-2401. PMID: 25804288, DOI: 10.1017/s0033291715000380.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdult Survivors of Child Adverse EventsDiagnostic and Statistical Manual of Mental DisordersEnvironmental ExposureFemaleGermanyHelp-Seeking BehaviorHumansMaleModels, PsychologicalMood DisordersObsessive-Compulsive DisorderPsychopathologyPsychotic DisordersRisk FactorsSeverity of Illness IndexSubstance-Related DisordersUrban PopulationYoung AdultConceptsNon-psychotic disordersNon-psychotic psychopathologyRisk factorsMood disordersPsychotic experiencesHelp-seeking behaviorDSM-IV mood disordersEnvironmental exposuresSevere clinical stateDose-response fashionEnvironmental risk factorsPresence of psychosisIndex of severitySubthreshold psychotic experiencesIllness severityClinical stateGeneral psychopathologyCannabis useDisordersSeverityCompulsive disorderPsychotic psychopathologyPsychosisPsychopathologyTrauma
2013
Science, Psychiatry, and the DSM.
Atbaşoğlu E, Gülöksüz S. Science, Psychiatry, and the DSM. Turkish Journal Of Psychiatry 2013, 24: 202-12. PMID: 24049010, DOI: 10.5080/u7220.Peer-Reviewed Original ResearchMeSH KeywordsDiagnostic and Statistical Manual of Mental DisordersHumansMental DisordersPsychiatryScienceTurkeyConceptsGeneral medical conditionsGood vantage pointContemporary psychiatryBranches of medicineDetailed medical assessmentGeneral medical diagnosisVantage pointPsychiatryMedical conditionsApproach todayDSM disordersMedical assessmentStructural abnormalitiesMental disordersBiopsychosocial approachPsychiatric phenomenaSpecific causesStatistical ManualDiagnostic reliabilityScientific problemsDimensions of moodDisordersScienceMain scientific problemsDisciplines