2023
Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study
Fusar-Poli L, Prachason T, Erzin G, Pries L, Brondino N, Politi P, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Andric-Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Escarti M, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Üçok A, Alptekin K, Saka M, Arango C, O'Donovan M, van Os J, Rutten B, Guloksuz S, investigators G. Examining the association between exposome score for schizophrenia and cognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. Psychiatry Research 2023, 323: 115184. PMID: 37015164, DOI: 10.1016/j.psychres.2023.115184.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCognitionCognition DisordersCross-Sectional StudiesExposomeFemaleHumansMaleSchizophreniaSchizophrenic PsychologySiblingsConceptsBenton Facial Recognition TestDegraded Facial Affect Recognition TaskWechsler Adult Intelligence Scale-Third EditionSchizophrenia spectrum disordersSocial cognitionCognitive domainsFacial affect recognition taskAffect recognition taskFacial Recognition TestCognitive impairmentRecognition testSpectrum disorderRecognition taskCross-sectional sampleHealthy controlsCognitionPsychosis spectrumShort versionUnaffected siblingsNeurocognitionEUGEI studySchizophreniaPerceptionImpairmentSiblings
2020
Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia
Pries L, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, Guloksuz S. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia. JAMA Psychiatry 2020, 77: 1296-1304. PMID: 32805017, PMCID: PMC7711318, DOI: 10.1001/jamapsychiatry.2020.2304.Peer-Reviewed Original ResearchConceptsRecent stressful life eventsStressful life eventsAssociations of SLEsPoor physical healthMental health outcomesHealth outcomesPhysical healthGeneral populationPopulation-based prospective cohort studyPRS-SCZNetherlands Mental Health SurveyES-SCZMental healthProspective cohort studyIncidence Study-2Modifiable environmental factorsAdulthood stressful life eventsMental Health SurveyDutch general populationPoor mental healthPopulation-based health outcomesLife eventsCohort studyMean ageHealth Survey
2019
Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study. Psychological Medicine 2019, 50: 1884-1897. PMID: 31414981, DOI: 10.1017/s003329171900196x.Peer-Reviewed Original ResearchConceptsPsychotic disordersPolygenic riskSchizophrenia polygenic riskGene-environment interactionsGenetic riskRelatives of patientsFirst-degree relativesPsychosis phenotypeAverage genetic riskIntermediate phenotypesHealthy siblingsCognitive intermediate phenotypesControl groupAnalysis of associationAverage riskPatientsEstimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study
Pries L, Lage-Castellanos A, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altinyazar V, Yalinçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Alizadeh B, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Luykx J, van Winkel R, Rutten B, van Os J, Arango C, O’Donovan M, Rutten B, van Os J, Guloksuz S. Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study. Schizophrenia Bulletin 2019, 45: 960-965. PMID: 31508804, PMCID: PMC6737483, DOI: 10.1093/schbul/sbz054.Peer-Reviewed Original ResearchIdentifying psychosis spectrum disorder from experience sampling data using machine learning approaches
Stamate D, Katrinecz A, Stahl D, Verhagen S, Delespaul P, van Os J, Guloksuz S. Identifying psychosis spectrum disorder from experience sampling data using machine learning approaches. Schizophrenia Research 2019, 209: 156-163. PMID: 31104913, DOI: 10.1016/j.schres.2019.04.028.Peer-Reviewed Original Research
2017
DNA Methylation in Schizophrenia
Pries L, Gülöksüz S, Kenis G. DNA Methylation in Schizophrenia. Advances In Experimental Medicine And Biology 2017, 978: 211-236. PMID: 28523549, DOI: 10.1007/978-3-319-53889-1_12.Peer-Reviewed Original ResearchConceptsAberrant DNA modificationsGenome-wide approachesDNA methylation changesCandidate gene studiesHigh heritability estimatesGenetic susceptibility lociHeritable psychiatric conditionEpigenetic mechanismsDNA methylationEpigenetic processesMethylation changesDNA modificationsComplex phenotypesGene studiesSusceptibility lociHeritability estimatesRelevant environmental risk factors
2015
Temperament characteristics in patients with panic disorder and their first-degree relatives
Altınbaş G, Altınbaş K, Gülöksüz S, Gülöksüz S, Aydemir Ö, Özgen G. Temperament characteristics in patients with panic disorder and their first-degree relatives. Comprehensive Psychiatry 2015, 60: 73-77. PMID: 25967357, DOI: 10.1016/j.comppsych.2015.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyCase-Control StudiesFemaleHumansIrritable MoodMaleMiddle AgedPanic DisorderSelf ReportTemperamentConceptsFirst-degree relativesHealthy controlsPanic disorderIrritable temperament scoresPanic Agoraphobia ScaleAnxious temperament scoresTemperament characteristicsTrait Anxiety InventoryClinical characteristicsPatient groupClinical conditionsSan Diego AutoquestionnairePatientsTemperament scoresTrait markerAgoraphobia ScaleAnxiety disordersProspective designDisordersStudy sampleHeritable anxiety disordersAnxiety InventoryTemperament EvaluationEducation levelIntermediate phenotypes