Involvement of hemoglobins in the pathophysiology of Alzheimer's disease
Altinoz M, Guloksuz S, Schmidt-Kastner R, Kenis G, Ince B, Rutten B. Involvement of hemoglobins in the pathophysiology of Alzheimer's disease. Experimental Gerontology 2019, 126: 110680. PMID: 31382012, DOI: 10.1016/j.exger.2019.110680.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseNeurodegenerative disordersPathogenesis of ADCourse of ADNitric oxideIncreased Hb levelsTangle-bearing neuronsInner mitochondrial membraneBlood-brain barrierAD brain samplesLevels of HbCentral nervous systemHeme-containing proteinsRole of HbFunction of intracellularMultiple beneficial effectsHb transcriptionHb levelsAD brainImmunohistochemical studyMitochondrial membranePossible candidate moleculesBiological processesCellular respirationNervous system