2019
Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia
Sahbaz C, Özer O, Kurtulmus A, Kırpınar I, Sahin F, Guloksuz S. Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia. Metabolic Brain Disease 2019, 34: 865-874. PMID: 30758707, DOI: 10.1007/s11011-019-00395-3.Peer-Reviewed Original ResearchConceptsBody mass indexSerum melatonin concentrationsPittsburgh Sleep Quality IndexHealthy controlsMelatonin concentrationsCognitive impairmentMorningness-Eveningness QuestionnaireHigher body mass indexLower MEQ scoresSleep Quality IndexNegative Syndrome ScaleEnzyme-linked immunosorbentCircadian preferenceMelatonin groupMass indexMelatonergic pathwaysHC groupPatientsNeurodevelopmental originSyndrome ScaleMelatonin levelsPatient samplesSchizophreniaMelatoninMEQ scores
2017
Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
van Os J, van der Steen Y, Islam M, Gülöksüz S, Rutten B, Simons C. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine 2017, 47: 2421-2437. PMID: 28436345, DOI: 10.1017/s0033291717000915.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresHealthy comparison subjectsPsychotic disordersAttribution of salienceAffective episodesComparison subjectsIntelligence quotientTotal scorePolygenic riskFirst-degree relativesElevated genetic riskLower intelligence quotientManic episodesHealthy relativesRisk scoreNeurodevelopmental alterationsDepression subscaleLifetime ratesSimilar associationPsychosis riskFloor effectsGenetic riskPositive subscalePsychosis phenotypeDisorders