2021
What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder?
Hasmi L, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Richards A, Lin B, O'Donovan M, Luykx J, Rutten B, Guloksuz S, van Os J. What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder? Epidemiology And Psychiatric Sciences 2021, 30: e53. PMID: 34225831, PMCID: PMC8264801, DOI: 10.1017/s204579602100041x.Peer-Reviewed Original ResearchConceptsNon-psychotic disordersClinical high-risk stateClinical high riskHigh-risk stateHigh riskPsychotic symptomsPsychotic experiencesProspective general population cohortEarly psychotic experiencesIncident psychotic experiencesGeneral population cohortHealth service usePsychosis risk statesDrug use disordersPositive family historySchizophrenia polygenic risk scoresPsychosis incidenceAntipsychotic medicationYearly incidenceFamily historyPolygenic risk scoresRisk scoreAPS researchPRS-SZService use
2020
Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?
Marsman A, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Luykx J, Rutten B, Guloksuz S, van Os J. Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health? Schizophrenia Bulletin 2020, 46: 1353-1362. PMID: 33259628, PMCID: PMC7707067, DOI: 10.1093/schbul/sbaa086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAgedFamilyFemaleGenetic Predisposition to DiseaseHealth SurveysHumansLife Change EventsLongitudinal StudiesMaleMarijuana UseMiddle AgedMultifactorial InheritanceNetherlandsPsychotic DisordersSchizophreniaSocioeconomic FactorsUrban PopulationYoung AdultConceptsPolygenic risk scoresSchizophrenia polygenic risk scoresMental healthFamily historyNetherlands Mental Health SurveyPopulation-based studyPolygenic riskChildhood traumaMental Health SurveyMental health changesEnvironmental risk factorsGeneral mental healthPopulation mental healthGeneral population sampleSomatic painRisk factorsHealth SurveyRisk scorePRS-SZBipolar disorderEpidemiological settingsMental disordersHealth changesAttributable variationPain