2023
The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study
Erzin G, Atbaşoğlu C, Fusar-Poli L, Saka M, Üçok A, Alptekin K, Os J, Akay G, Gülöksüz S. The association between exposome score for schizophrenia and metabolic parameters in individuals with schizophrenia and healthy controls: Findings from the EUGEI study. European Psychiatry 2023, 66: s264-s264. PMCID: PMC10596217, DOI: 10.1192/j.eurpsy.2023.601.Peer-Reviewed Original ResearchMetabolic parametersHealthy controlsES-SCZHigh-density lipid levelsDiastolic blood pressureNational Schizophrenia NetworksExposome scorePhysical health outcomesBlood pressureAnalysis ageLipid levelsGlucose levelsGene-environment interactionsPsychosis developmentLinear regression analysisHealth outcomesPrenatal periodSchizophrenia NetworkSchizophreniaClinical implementationEnvironmental exposuresEUGEI studyNongenetic exposuresRegression analysisImportant metabolic parameters
2022
Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study
Pries L, Moore T, Visoki E, Sotelo I, Barzilay R, Guloksuz S. Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study. Biological Psychiatry Global Open Science 2022, 2: 283-291. PMID: 36325038, PMCID: PMC9616253, DOI: 10.1016/j.bpsgos.2022.05.005.Peer-Reviewed Original ResearchPregnancy/birth complicationsExposome factorsGeneral psychopathologyBirth complicationsCognitive Development StudyGeneral psychopathology factorAdolescent Brain Cognitive Development (ABCD) studyClinical symptomsAdjusted modelMultiple comparison correctionExposome approachLinear regression analysisMental disordersNeurodevelopmental psychopathologyChildhood adversityPsychosisEnvironmental exposuresABCD studyNongenetic factorsComplicationsRegression analysisPsychopathology factorNeighborhood environmentPsychopathologyExposomeLongitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study
Erzin G, Pries L, Dimitrakopoulos S, Ralli I, Xenaki L, Soldatos R, Vlachos I, Selakovic M, Foteli S, Kosteletos I, Nianiakas N, Mantonakis L, Rizos E, Kollias K, Os J, Guloksuz S, Stefanis N. Longitudinal association between exposome score for schizophrenia and clinical features: results from the Athens First-Episode Psychosis Research Study. European Psychiatry 2022, 65: s760-s760. PMCID: PMC9567635, DOI: 10.1192/j.eurpsy.2022.1963.Peer-Reviewed Original ResearchPANSS total scoreFirst-episode psychosisClinical featuresES-SCZTotal scoreIllness coursePsychosis developmentLongitudinal associationsEnvironmental exposuresTime interactionNegative Syndrome ScaleExposome scoreEpisode psychosisSyndrome ScaleSymptom severitySchizophreniaEnvironmental predispositionMultilevel regression analysisScoresRegression analysisFollowPrevious reportsBaselineAssociationCurrent study
2019
Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms
Pinckaers F, Rotee I, Nwosu C, Krolinski P, Smeets A, Gülöksüz S, de Jong L, Vaessen T, Damen T, Uittenboogaard A, Schäfer A, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Rutten B, van Os J, Drukker M. Evidence for interaction between genetic liability and childhood trauma in the development of psychotic symptoms. Social Psychiatry And Psychiatric Epidemiology 2019, 54: 1045-1054. PMID: 31209522, DOI: 10.1007/s00127-019-01711-z.Peer-Reviewed Original ResearchConceptsChildhood traumaGenetic liabilityImpact of CTSymptom Checklist-90 scoresMixed-effects linear regression analysisSubthreshold psychotic experiencesChildhood Trauma Questionnaire-Short FormExpression of psychosisGeneral population twinsQuestionnaire-Short FormPsychosis expressionMultilevel mixed-effects linear regression analysesRisk factorsPsychotic symptomsSymptom subscalesLinear regression analysisSubthreshold expressionTotal scoreStatistical significancePsychic Experience (CAPE) questionnaireRegression analysis
2016
Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network
Guloksuz S, van Nierop M, Bak M, de Graaf R, ten Have M, van Dorsselaer S, Gunther N, Lieb R, van Winkel R, Wittchen H, van Os J. Exposure to environmental factors increases connectivity between symptom domains in the psychopathology network. BMC Psychiatry 2016, 16: 223. PMID: 27391407, PMCID: PMC4939022, DOI: 10.1186/s12888-016-0935-1.Peer-Reviewed Original ResearchConceptsMental disordersSymptom dimensionsNetherlands Mental Health SurveyNEMESIS-1Symptom connectivityContinuous symptom dimensionsEnvironmental exposuresSelf-report Symptom Checklist-90Mental Health SurveySymptom Checklist-90Health SurveyPsychotic symptomsIncidence studyPopulation cohortSelf-reported psychopathologyConclusionsOur findingsDiagnostic categoriesSymptom domainsIndependent population cohortsRisk loadPsychopathology StudyDisordersRegression analysisCohortSymptoms