2021
What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder?
Hasmi L, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Richards A, Lin B, O'Donovan M, Luykx J, Rutten B, Guloksuz S, van Os J. What makes the psychosis ‘clinical high risk’ state risky: psychosis itself or the co-presence of a non-psychotic disorder? Epidemiology And Psychiatric Sciences 2021, 30: e53. PMID: 34225831, PMCID: PMC8264801, DOI: 10.1017/s204579602100041x.Peer-Reviewed Original ResearchConceptsNon-psychotic disordersClinical high-risk stateClinical high riskHigh-risk stateHigh riskPsychotic symptomsPsychotic experiencesProspective general population cohortEarly psychotic experiencesIncident psychotic experiencesGeneral population cohortHealth service usePsychosis risk statesDrug use disordersPositive family historySchizophrenia polygenic risk scoresPsychosis incidenceAntipsychotic medicationYearly incidenceFamily historyPolygenic risk scoresRisk scoreAPS researchPRS-SZService use
2020
Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort
Guloksuz S, Pries L, Ten Have M, de Graaf R, van Dorsselaer S, Klingenberg B, Bak M, Lin B, van Eijk K, Delespaul P, van Amelsvoort T, Luykx J, Rutten B, van Os J. Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort. World Psychiatry 2020, 19: 199-205. PMID: 32394548, PMCID: PMC7215054, DOI: 10.1002/wps.20755.Peer-Reviewed Original ResearchPsychosis high-risk statePopulation attributable fractionHigh-risk stateNon-psychotic mental disordersPsychosis risk statesDrug use disordersClinical high riskPsychosis incidenceProspective studyClinical psychosisIncidence rateMood disordersUse disordersMental disordersPopulation-based prospective studyCox proportional hazards modelProportional hazards modelHigher relative riskDSM-IV diagnosisPopulation-based improvementsRisk stateComprehensive prevention strategyAttributable fractionRelative riskPsychosis outcomes