Interaction Between Polygenic Liability for Schizophrenia and Childhood Adversity Influences Daily-Life Emotional Dysregulation and Psychosis Proneness
Pries L, Klingenberg B, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Cinar O, Bochao L, Luykx J, Rutten B, van Os J, Guloksuz S. Interaction Between Polygenic Liability for Schizophrenia and Childhood Adversity Influences Daily-Life Emotional Dysregulation and Psychosis Proneness. Biological Psychiatry 2020, 87: s1-s2. DOI: 10.1016/j.biopsych.2020.02.033.Peer-Reviewed Original ResearchEmotional dysregulationPsychosis pronenessPolygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
Pries L, Klingenberg B, Menne‐Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Cinar O, Lin B, Luykx J, Rutten B, van Os J, Guloksuz S. Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness. Acta Psychiatrica Scandinavica 2020, 141: 465-475. PMID: 32027017, PMCID: PMC7318228, DOI: 10.1111/acps.13158.Peer-Reviewed Original ResearchConceptsDaily life stressorsChildhood adversityEmotion dysregulationPositive affectPsychosis pronenessMomentary mental statesEcological momentary assessmentChildhood Trauma QuestionnaireGene-environment correlationNegative affectMental statesMomentary assessmentPsychosis expressionTrauma QuestionnaireAdversityAffectYoung adultsStressorsNovel evidencePolygenic liabilityInteraction effectsPronenessSchizophreniaHigh PRSState domain