2024
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociation
2023
Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding
Klingenberg B, Guloksuz S, Pries L, Cinar O, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Lin B, Luykx J, van Os J, Rutten B. Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding. Personality Neuroscience 2023, 6: e5. PMID: 38107775, PMCID: PMC10725776, DOI: 10.1017/pen.2023.2.Peer-Reviewed Original ResearchChildhood adversityParental bondingLife eventsPositive life eventsNegative life eventsGene-environment correlationGenetic vulnerabilityEysenck Personality QuestionnaireParental bonding stylesExpression of neuroticismPaternal bondingNeuroticismPersonality QuestionnaireAdversityMultilevel mixed-effects modelsMaternal bonding