2021
Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness
Luykx J, Loef D, Lin B, van Diermen L, Nuninga J, van Exel E, Oudega M, Rhebergen D, Schouws S, van Eijndhoven P, Verwijk E, Schrijvers D, Birkenhager T, Ryan K, Arts B, van Bronswijk S, Kenis G, Schurgers G, Baune B, Arns M, van Dellen E, Somers M, Sommer I, Boks M, Gülöksüz S, McLoughlin D, Dols A, Rutten B. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness. Biological Psychiatry 2021, 91: 531-539. PMID: 34955169, DOI: 10.1016/j.biopsych.2021.10.013.Peer-Reviewed Original ResearchConceptsMajor depressive episodeHamilton Depression Rating Scale scoresDepression Rating Scale scoresRating Scale scoresPolygenic risk scoresPRS-SCZECT outcomeElectroconvulsive therapyScale scoreSevere major depressive episodeUnipolar major depressive episodeMajor depressive disorderSecondary outcomesAntidepressant responseECT treatmentDepressive episodeSubgroup analysisECT effectivenessPsychotic featuresDepressive disorderTreatment responseMAIN OUTCOMEEffective treatmentRisk scoreTherapy effectiveness
2020
Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
Erzin G, Özkaya G, Topçuoğlu C, Yüksel R, Erel Ö, Yurt E, Göka E, Gülöksüz S. Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression. Clinical Psychopharmacology And Neuroscience 2020, 18: 395-401. PMID: 32702218, PMCID: PMC7383011, DOI: 10.9758/cpn.2020.18.3.395.Peer-Reviewed Original ResearchDisulfide/total thiol ratiosTotal thiol ratiosThiol-disulfide homeostasisBipolar depressionHealthy controlsUnipolar depressionNative thiol ratioBipolar disorderDisulfide levelsThiol ratioDepressive disorderNative thiolAnkara Numune TrainingThiol/disulfide homeostasisDisulfide/native thiol ratioOxidative stress markersUnipolar depressive disorderDSM-5 criteriaLevels of disulfideUD groupOutpatient clinicClinical entityDepressive episodeResearch HospitalTherapeutic differences
2011
P03-79 - How do european psychiatry trainees prescribe when treating depression, and what influences decision-making? (Survey of the European Federation of Psychiatric Trainees Research Group)
Jauhar S, Guloksuz S, Marques J, Nawka A, Roventa C, Psaras R, Andlauer O, Lydall G, De Vriendt N, Mendonca L, Van Zanten J, Dumiterscu I, Nwachukwu I, Riese F, Group E. P03-79 - How do european psychiatry trainees prescribe when treating depression, and what influences decision-making? (Survey of the European Federation of Psychiatric Trainees Research Group). European Psychiatry 2011, 26: 1248. DOI: 10.1016/s0924-9338(11)72953-4.Peer-Reviewed Original ResearchSide effect profileClinical practiceChoice of antidepressantSevere depressive episodeAntidepressant medicationDepressive episodeTreatment choiceResponse rateAntidepressantsSimilar antidepressantsSubsequent guidelinesPatientsEvidence baseMinimum response rateGuideline suggestionsRecent evidenceMedicationsEuropean traineesPsychiatry traineesEfficacyLittle evidenceSample sizeTraineesFactorsRecent literature
2010
Cytokine levels in euthymic bipolar patients
Guloksuz S, Cetin E, Cetin T, Deniz G, Oral E, Nutt D. Cytokine levels in euthymic bipolar patients. Journal Of Affective Disorders 2010, 126: 458-462. PMID: 20537397, DOI: 10.1016/j.jad.2010.04.027.Peer-Reviewed Original ResearchConceptsEuthymic bipolar patientsBipolar patientsCytokine levelsHealthy controlsBipolar disorderDepressive episodeLithium monotherapyIL-10 levelsIL-4 levelsSerum cytokine levelsPro-inflammatory stateEffects of medicationNeuro-immune modulationTerms of agePatients 16Cytokine profileCytokine productionPresent studyIL-2IL-4IL-5Healthy volunteersPsychiatric disordersPatientsFlow cytometry