2023
Comprehensive dissection of prevalence rates, sex differences, and blood level-dependencies of clozapine-associated adverse drug reactions
van der Horst M, Meijer Y, de Boer N, Guloksuz S, Hasan A, Siskind D, Wagner E, consortium C, Müderrisoğlu A, Privat A, Bouhuis A, Hasan A, Jongkind A, Gonzalez-Pinto A, Santacana A, D'Agostino A, Ertugrul A, Yağcioğlu A, Crespo-Facorro B, Sanchez-Barbero B, Spuch C, Morgenroth C, de Pinedo C, Casetta C, Bousman C, Pantelis C, Ovejas-Catalán C, Garcia-Rizo C, Okhuijsen-Pfeifer C, Cohen D, Ristic D, Beld E, Repo-Tiihonen E, Wagner E, Jeger-Land E, Vilella E, Bekema E, Sepúlveda S, Seghi F, Wiedenmann F, Martini F, Serio F, Vairano F, Mercuriali G, Boido G, Yoca G, van Beek H, Gijsman H, Tuppurainen H, Everall I, Novakovic I, Zorrilla I, Erdoğan I, Sapienza J, Bogers J, Tiihonen J, Vázquez-Bourgon J, van Os J, Schneider-Thoma J, Luykx J, Grootens K, Mar-Barrutia L, Martorell L, Bak M, Spangaro M, de Vos M, de Koning M, Garriga M, Lähteenvuo M, Bosia M, van der Horst M, Babaoğlu M, Veereschild M, Manchia M, Edlinger M, Fuentes-Pérez P, Paribello P, Lopez-Pena P, Kahn R, Cavallaro R, Veerman S, Gutwinski S, Schreiter S, Ripke S, Baltanás T, Oviedo-Salcedo T, Hallikainen T, Görlitz T, Alink W, Ayhan Y, Okhuijsen-Pfeifer C, Luykx J. Comprehensive dissection of prevalence rates, sex differences, and blood level-dependencies of clozapine-associated adverse drug reactions. Psychiatry Research 2023, 330: 115539. PMID: 37988817, DOI: 10.1016/j.psychres.2023.115539.Peer-Reviewed Original ResearchConceptsAdverse drug reactionsClinical factorsDrug reactionsPrevalence ratesCommon adverse drug reactionsWeight gainSignificant weight gainMulti-center studyImproved treatment outcomesClozapine blood levelsClozapine monotherapyClozapine treatmentLower BMIBlood levelsTreatment outcomesHigh prevalencePrevalenceMean numberYounger participantsSex differencesParticipantsTreatmentComprehensive dissectionConstipationHypersalivation
2021
Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Gunther N, Luykx J, Rutten B, Guloksuz S. Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis. Psychological Medicine 2021, 53: 1825-1833. PMID: 37310330, PMCID: PMC10106290, DOI: 10.1017/s0033291721003445.Peer-Reviewed Original ResearchConceptsClinical characterizationPolygenic risk scoresClinical valueProspective general population cohortGeneral population cohortUse of medicationsPopulation attributable fractionPrediction of needDSM-IV diagnosisHealth care outcomesSymptom dimensionsTransdiagnostic frameworkClinical factorsAttributable fractionEtiological factorsRisk scoreCare outcomesCategorical algorithmService usePopulation cohortSociodemographic factorsTransdiagnostic symptom dimensionsPhysical healthDiagnosisDSM diagnosesClinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review
Sneller M, de Boer N, Everaars S, Schuurmans M, Guloksuz S, Cahn W, Luykx J. Clinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review. Frontiers In Psychiatry 2021, 12: 625935. PMID: 33868046, PMCID: PMC8044798, DOI: 10.3389/fpsyt.2021.625935.Peer-Reviewed Original ResearchSecond-generation antipsychoticsC-reactive proteinSchizophrenia spectrum disordersMetabolic syndromeCurrent BMIGenetic factorsHigher ageHigher white blood cell countSystematic reviewWhite blood cell countSevere mental illness experienceHigher baseline BMIRisk of MetS.Cardiovascular disease mortalityBlood cell countCross-sectional studyHigher current BMIMore studiesMental illness experienceSpectrum disorderSGA exposureBaseline BMICohort studyClinical factorsTobacco smoking