2021
Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Bak M, Kenis G, Lin B, Gunther N, Luykx J, Rutten B, Guloksuz S. Context v. algorithm: evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis. Psychological Medicine 2021, 53: 1825-1833. PMID: 37310330, PMCID: PMC10106290, DOI: 10.1017/s0033291721003445.Peer-Reviewed Original ResearchConceptsClinical characterizationPolygenic risk scoresClinical valueProspective general population cohortGeneral population cohortUse of medicationsPopulation attributable fractionPrediction of needDSM-IV diagnosisHealth care outcomesSymptom dimensionsTransdiagnostic frameworkClinical factorsAttributable fractionEtiological factorsRisk scoreCare outcomesCategorical algorithmService usePopulation cohortSociodemographic factorsTransdiagnostic symptom dimensionsPhysical healthDiagnosisDSM diagnoses
2020
Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort
Guloksuz S, Pries L, Ten Have M, de Graaf R, van Dorsselaer S, Klingenberg B, Bak M, Lin B, van Eijk K, Delespaul P, van Amelsvoort T, Luykx J, Rutten B, van Os J. Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort. World Psychiatry 2020, 19: 199-205. PMID: 32394548, PMCID: PMC7215054, DOI: 10.1002/wps.20755.Peer-Reviewed Original ResearchPsychosis high-risk statePopulation attributable fractionHigh-risk stateNon-psychotic mental disordersPsychosis risk statesDrug use disordersClinical high riskPsychosis incidenceProspective studyClinical psychosisIncidence rateMood disordersUse disordersMental disordersPopulation-based prospective studyCox proportional hazards modelProportional hazards modelHigher relative riskDSM-IV diagnosisPopulation-based improvementsRisk stateComprehensive prevention strategyAttributable fractionRelative riskPsychosis outcomes