An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae
Ortigoza M, Blaser S, Zafar M, Hammond A, Weiser J. An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae. MBio 2018, 9: 10.1128/mbio.02359-18. PMID: 30563897, PMCID: PMC6299224, DOI: 10.1128/mbio.02359-18.Peer-Reviewed Original ResearchConceptsInfluenza A virusSusceptible to influenza A virusesInfluenza A virus transmissionInfant mouse modelUpper respiratory tractInfluenza A virus sheddingHumoral immunityMouse modelInfluenza A virus strainsTransmission of influenza A virusesAnimal modelsVirus strainsInfluenza virus strainsUpper respiratory tract floraGuinea pig modelAntagonizing transmissionAdult miceSusceptible recipientsA virusMarker of infectiousnessSialidase expressionPandemic potentialViral sheddingRespiratory tractPig model