2014
Global microRNA depletion suppresses tumor angiogenesis
Chen S, Xue Y, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA. Global microRNA depletion suppresses tumor angiogenesis. Genes & Development 2014, 28: 1054-1067. PMID: 24788094, PMCID: PMC4035535, DOI: 10.1101/gad.239681.114.Peer-Reviewed Original ResearchConceptsUntranslated regionCRISPR/Multiplexed CRISPR/HIF transcriptional activityHypoxia-inducible factor-1Tumor angiogenesisMicroRNA-binding sitesGenome engineeringExpression profilingTranscriptional activityHypoxia responseBalance of angiogenesisHIF transcriptionMicroRNA deficiencyMicroRNAsFIH1Factor 1Angiogenesis genesDeficient angiogenesisAngiogenesisVEGF productionTranscription
2012
Reshaping of global gene expression networks and sex‐biased gene expression by integration of a young gene
Chen S, Ni X, Krinsky BH, Zhang YE, Vibranovski MD, White KP, Long M. Reshaping of global gene expression networks and sex‐biased gene expression by integration of a young gene. The EMBO Journal 2012, 31: 2798-2809. PMID: 22543869, PMCID: PMC3380208, DOI: 10.1038/emboj.2012.108.Peer-Reviewed Original ResearchConceptsSex-biased gene expressionNew genesGene expressionPre-existing genesCo-evolved interactionsGenomic binding profileNew gene networksComparative expression profilingOrgan expression patternsGene expression networksEssential biological processesDiverse taxaYoung genesExpression networksGene networksRelated speciesGenetic networksDownstream genesGenomic levelExpression profilingExpression patternsBiological processesGenesMale fecundityCAF40Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila
Chen S, Spletter M, Ni X, White KP, Luo L, Long M. Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila. Cell Reports 2012, 1: 118-132. PMID: 22832161, PMCID: PMC4382513, DOI: 10.1016/j.celrep.2011.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAgingAmino Acid SequenceAnimalsArthropod AntennaeBrainDrosophila melanogasterDrosophila ProteinsEvolution, MolecularFeeding BehaviorFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGenes, InsectMaleMolecular Sequence DataMushroom BodiesNeuronsSelection, GeneticSex CharacteristicsSynaptic TransmissionTranscriptomeConceptsNew genesForaging behaviorMushroom bodiesYoung retrogenesAdaptive evolutionPhenotypic evolutionEvolutionary signaturesYoung genesNatural selectionGenetic basisBrain genesExpression profilingComparative behavioral analysisBrain evolutionGenesOlfactory circuitDrosophilaNew functionsAnimal behaviorNeuronal expressionExpressionRetrogenesNeural circuitsEvolutionRecent evolution
2011
Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster
Chen Y, Dai H, Chen S, Zhang L, Long M. Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster. PLOS ONE 2011, 6: e18853. PMID: 21541324, PMCID: PMC3082539, DOI: 10.1371/journal.pone.0018853.Peer-Reviewed Original ResearchMeSH KeywordsAnimal StructuresAnimalsBase PairingBase SequenceBrainConserved SequenceCourtshipDrosophila melanogasterFemaleGene Expression ProfilingGene Expression RegulationGenome, InsectGreen Fluorescent ProteinsMaleMolecular Sequence DataMutationOrgan SpecificityPeripheral Nervous SystemPromoter Regions, GeneticRNA, UntranslatedSexual Behavior, AnimalTransformation, GeneticConceptsDrosophila melanogasterBp regionCourtship behaviorNon-coding RNA genesWhole genome expression profilingBp upstream regionTissue-specific expressionGenome expression profilingMale courtship behaviorMale accessory glandsMelanogaster subgroupDrosophila speciesD. virilisRNA genesGene categoriesProtein functionKnockout mutationsWing hairsMale courtshipTarget genesExpression profilingGFP signalNegative regulatorEnhancer elementsExpression signals