2019
Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo
Codina A, Renauer PA, Wang G, Chow RD, Park JJ, Ye H, Zhang K, Dong MB, Gassaway B, Ye L, Errami Y, Shen L, Chang A, Jain D, Herbst RS, Bosenberg M, Rinehart J, Fan R, Chen S. Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo. Cell Systems 2019, 8: 136-151.e7. PMID: 30797773, PMCID: PMC6592847, DOI: 10.1016/j.cels.2019.01.004.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomic profilingExtracellular protein productionCancer cellsMutant cellsFunctional interrogationGenetic programCRISPR screensTranscriptomic profilingTumor-intrinsic mutationsTranscriptomic alterationsTumor microenvironmentProtein productionPRKAR1A lossGenetic makeupHost myeloid cellsTumor-intrinsic factorsDrastic alterationsCytometry analysisConvergent identificationMyeloid cellsCellsImmunocompetent hostsCancer immunityMutant tumorsHost
2018
Sno-derived RNAs are prevalent molecular markers of cancer immunity
Chow RD, Chen S. Sno-derived RNAs are prevalent molecular markers of cancer immunity. Oncogene 2018, 37: 6442-6462. PMID: 30072739, PMCID: PMC6294694, DOI: 10.1038/s41388-018-0420-z.Peer-Reviewed Original ResearchConceptsCancer immunityCytolytic T cell activityCancer typesHuman cancer immunityTumor immune signatureT cell infiltrationT cell activityTumor immune microenvironmentHuman cancersClinical outcomesImmunosuppressive markersPatient survivalCell infiltrationDistinct cancer typesTumor vasculatureCell activityPatient samplesExpression signaturesImmunityCancerMarkersMolecular markersLike propertiesSdRNAsLarge panel