2021
Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ
Gupta A, Jhawar SR, Sayan M, Yehia ZA, Haffty BG, Yu JB, Wang SY. Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ. Journal Of Clinical Oncology 2021, 39: 2386-2396. PMID: 34019456, PMCID: PMC10166354, DOI: 10.1200/jco.21.00831.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Intraductal, NoninfiltratingChemotherapy, AdjuvantCost-Benefit AnalysisFemaleHumansMaleMiddle AgedConceptsAromatase inhibitorsTreatment strategiesRadiation treatmentDuctal carcinomaAge 40Risk reductionAdjuvant treatment strategiesGood-risk patientsLarge randomized trialsAdverse event ratesOptimal treatment strategyRelative risk reductionCohort of womenBreast cancer casesLow-value careQuality of lifeCost-effectiveness analysisBase-case resultsHormonal therapyAdjuvant treatmentMost patientsPatient ageSecondary malignanciesRandomized trialsRecurrence rate
2018
Associations Between Sentinel Lymph Node Biopsy and Complications for Patients with Ductal Carcinoma In Situ
Killelea BK, Long JB, Dang W, Mougalian SS, Evans SB, Gross CP, Wang SY. Associations Between Sentinel Lymph Node Biopsy and Complications for Patients with Ductal Carcinoma In Situ. Annals Of Surgical Oncology 2018, 25: 1521-1529. PMID: 29516364, PMCID: PMC5928184, DOI: 10.1245/s10434-018-6410-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleHumansLymphedemaMastectomy, SegmentalPain, PostoperativeSentinel Lymph Node BiopsySeromaSurgical Wound InfectionConceptsSentinel lymph node biopsyBreast-conserving surgeryLymph node biopsySLNB useNode biopsyWound infectionDuctal carcinomaUse of SLNBEnd Results-Medicare datasetIncidence of complicationsShort-term complicationsMonths of diagnosisOlder patientsSubsequent mastectomyInitial treatmentResultsOur sampleConsensus guidelinesHigh riskOlder womenComplicationsMultivariate analysisPatientsWomenDCISMastectomy
2016
Preoperative breast magnetic resonance imaging and contralateral breast cancer occurrence among older women with ductal carcinoma in situ
Wang SY, Long JB, Killelea BK, Evans SB, Roberts KB, Silber A, Gross CP. Preoperative breast magnetic resonance imaging and contralateral breast cancer occurrence among older women with ductal carcinoma in situ. Breast Cancer Research And Treatment 2016, 158: 139-148. PMID: 27287780, PMCID: PMC5554869, DOI: 10.1007/s10549-016-3858-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreastBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleHumansIncidenceMagnetic Resonance ImagingNeoplasms, Multiple PrimaryNeoplasms, Second PrimaryPreoperative CarePropensity ScoreRetrospective StudiesSEER ProgramConceptsContralateral breast cancerMagnetic resonance imagingPreoperative magnetic resonance imagingDuctal carcinomaMRI usePreoperative breast magnetic resonance imagingEnd Results-Medicare datasetInvasive contralateral breast cancerOccult contralateral breast cancerResonance imagingSynchronous contralateral breast cancerImpact of MRIStage-specific incidence ratesPreoperative MRI useBreast magnetic resonance imagingBreast cancer occurrenceCBC eventsCBC ratesCumulative incidencePropensity score approachIncidence rateInvasive diseaseBreast cancerCancer occurrenceOlder women
2012
Network Meta-analysis of Margin Threshold for Women With Ductal Carcinoma In Situ
Wang SY, Chu H, Shamliyan T, Jalal H, Kuntz KM, Kane RL, Virnig BA. Network Meta-analysis of Margin Threshold for Women With Ductal Carcinoma In Situ. Journal Of The National Cancer Institute 2012, 104: 507-516. PMID: 22440677, PMCID: PMC3916966, DOI: 10.1093/jnci/djs142.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingConfounding Factors, EpidemiologicFemaleHumansMarkov ChainsMastectomy, SegmentalMonte Carlo MethodNeoplasm Recurrence, LocalOdds RatioConceptsIpsilateral breast tumor recurrenceBreast-conserving surgeryRisk of IBTRNegative marginsPositive marginsDuctal carcinomaOdds ratioBreast tumor recurrenceNegative surgical marginsNetwork Meta-AnalysisMixed treatment comparisonMargin thresholdIBTR eventsDCIS patientsMargin statusSurgical marginsTumor recurrenceMeta-regression techniquesReduced riskLower riskPatientsPubMed databaseCosmetic constraintsMeta-AnalysisRadiotherapy
2010
Ductal Carcinoma In Situ: Risk Factors and Impact of Screening
Virnig BA, Wang SY, Shamilyan T, Kane RL, Tuttle TM. Ductal Carcinoma In Situ: Risk Factors and Impact of Screening. JNCI Monographs 2010, 2010: 113-116. PMID: 20956813, PMCID: PMC5161075, DOI: 10.1093/jncimonographs/lgq024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingChemopreventionFemaleHormone Replacement TherapyHumansIncidenceMammographyMass ScreeningMiddle AgedMulticenter Studies as TopicRaloxifene HydrochlorideRandomized Controlled Trials as TopicRisk FactorsTamoxifenYoung AdultConceptsInvasive breast cancerBreast cancerDCIS incidenceDuctal carcinomaRisk factorsIncidence of DCISManagement of DCISRole of chemopreventionPositive family historyUse of mammographyImpact of screeningIncident DCISComedo necrosisMammography useFamily historyDCISHealth OfficeOlder ageIncidenceCancerNational InstituteCarcinomaFurther investigationAgeLiterature reviewAssociation Between Patient and Tumor Characteristics With Clinical Outcomes in Women With Ductal Carcinoma In Situ
Shamliyan T, Wang SY, Virnig BA, Tuttle TM, Kane RL. Association Between Patient and Tumor Characteristics With Clinical Outcomes in Women With Ductal Carcinoma In Situ. JNCI Monographs 2010, 2010: 121-129. PMID: 20956815, PMCID: PMC5161074, DOI: 10.1093/jncimonographs/lgq034.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBody Mass IndexBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingFemaleGonadal Steroid HormonesHumansMammographyMenopauseNeoplasm Recurrence, LocalNeoplasms, Hormone-DependentPrognosisRacial GroupsRandomized Controlled Trials as TopicReceptor, ErbB-2Receptors, EstrogenReceptors, ProgesteroneRiskSocioeconomic FactorsTreatment OutcomeTumor BurdenConceptsDuctal carcinomaClinical outcomesRecurrent cancerTumor characteristicsWorse outcomesNegative estrogen receptor statusAdvanced recurrent cancerPositive surgical marginsEstrogen receptor statusLarger tumor sizeHigh-risk categoryComposite prognostic indicesReceptor statusSurgical marginsPrognostic indexTumor sizeComedo necrosisPathological gradingClinical trialsObservational studyHigh riskHER2 receptorSynthesis of evidenceHigh mortalityYoung womenThe Impact of Surgery, Radiation, and Systemic Treatment on Outcomes in Patients With Ductal Carcinoma In Situ
Kane RL, Virnig BA, Shamliyan T, Wang SY, Tuttle TM, Wilt TJ. The Impact of Surgery, Radiation, and Systemic Treatment on Outcomes in Patients With Ductal Carcinoma In Situ. JNCI Monographs 2010, 2010: 130-133. PMID: 20956816, PMCID: PMC5161061, DOI: 10.1093/jncimonographs/lgq022.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsAntineoplastic Agents, HormonalAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingChemotherapy, AdjuvantCombined Modality TherapyDisease ProgressionFemaleHumansIncidenceMastectomyMastectomy, SegmentalNeoplasm Recurrence, LocalNeoplasms, Second PrimaryPrognosisRadiotherapy, AdjuvantRandomized Controlled Trials as TopicTamoxifenTreatment OutcomeConceptsBreast-conserving surgeryDuctal carcinomaInvasive carcinomaWhole breast radiation therapyImpact of surgeryTerms of recurrenceInvasive recurrenceRecurrent DCISDCIS recurrenceSystemic treatmentObservational studyRadiation therapyEquivalent outcomesCarcinomaMastectomyRecurrenceDCISSurgeryTamoxifenLower ratesOutcomesWomenLumpectomyPatientsMEDLINEIncorporating margin status information in treatment decisions for women with ductal carcinoma in situ: a decision analysis
Wang SY, Kuntz K, Tuttle T, Kane R. Incorporating margin status information in treatment decisions for women with ductal carcinoma in situ: a decision analysis. Breast Cancer Research And Treatment 2010, 124: 393-402. PMID: 20848183, DOI: 10.1007/s10549-010-1166-7.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingDecision Support TechniquesFemaleHumansMarkov ChainsMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalPatient PreferencePatient SelectionQuality-Adjusted Life YearsRadiotherapy, AdjuvantRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBreast-conserving surgeryQuality-adjusted life yearsRadiation therapyMargin statusDuctal carcinomaRT side effectsDecision-analytic Markov modelOne-way sensitivity analysesImportance of patientsProbabilistic sensitivity analysesDCIS treatmentInvasive recurrenceSalvage mastectomyOptimal treatmentHypothetical cohortTreatment decisionsLifetime horizonSide effectsLife yearsDCISPatientsWomenCarcinomaTreatment