2023
The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke
Peltier M, McKee S. The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke. Addiction Neuroscience 2023, 7: 100084. PMID: 37396408, PMCID: PMC10311966, DOI: 10.1016/j.addicn.2023.100084.Peer-Reviewed Original ResearchSex hormonesTobacco cravingMedication effectsMedication trialsSmoking behaviorCortisol responsePlacebo-controlled studySmoking cessation trialAd libitum periodGuanfacine's effectsCessation trialSmoking periodDrug effectsSecondary analysisGuanfacineEstradiolHormoneProgesteroneWomenCravingTrialsSex differencesContext of stressPresent studyPost-stress induction
2022
Police Harassment and Violence Against Transgender & Gender Diverse Sex Workers in the United States
Stenersen MR, Thomas K, McKee S. Police Harassment and Violence Against Transgender & Gender Diverse Sex Workers in the United States. Journal Of Homosexuality 2022, 71: 828-840. PMID: 36228168, PMCID: PMC11288376, DOI: 10.1080/00918369.2022.2132578.Peer-Reviewed Original ResearchAdverse Childhood Experiences and Pathways to Violent Behavior for Women and Men
Burke C, Ellis JD, Peltier MR, Roberts W, Verplaetse TL, Phillips S, Moore KE, Marotta PL, McKee SA. Adverse Childhood Experiences and Pathways to Violent Behavior for Women and Men. Journal Of Interpersonal Violence 2022, 38: 4034-4060. PMID: 35978533, PMCID: PMC9852029, DOI: 10.1177/08862605221113012.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesViolent behaviorChildhood experiencesViolent crimeFuture violenceViolenceLatent class analysisClass analysisBiological sexTypology groupsRepresentative sampleLow adversityCrimeExperienceWomenHigh riskFour-class modelMaltreatmentChildhood maltreatmentChildhood traumaRelationshipMenAdversityRiskCurrent findingsSex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways
Mineur YS, Garcia-Rivas V, Thomas MA, Soares AR, McKee SA, Picciotto MR. Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways. Psychopharmacology 2022, 239: 2041-2061. PMID: 35359158, PMCID: PMC9704113, DOI: 10.1007/s00213-022-06120-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol intakeInflammatory pathwaysAlcohol drinkingStress-induced alcohol drinkingSex differencesSex-dependent effectsStress-induced alcoholEffects of stressPreclinical behavioral modelsAlcohol-dependent behaviorsMicroglial activationClinical studiesPreclinical studiesInflammatory signalingNeuronal functionAlcohol seekingIntakeFuture studiesDrinkingDifferencesAmygdalaPathwayStudyWomen
2021
Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Verplaetse TL, Peltier MR, Roberts W, Burke C, Moore KE, Pittman B, McKee SA. Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Addictive Behaviors 2021, 123: 107055. PMID: 34311184, PMCID: PMC8419091, DOI: 10.1016/j.addbeh.2021.107055.Peer-Reviewed Original ResearchConceptsSignificant medical conditionsMedical conditionsNational Epidemiologic SurveyDSM-5 AUDRespiratory conditionsEpidemiologic SurveyAlcohol useU.S. National Epidemiologic SurveyRate of drinkingPresence of cancerAlcohol use disorderRelated Conditions-IIIHeavy alcohol useGreater health consequencesYears cancerProblematic alcohol useUse disordersOrgan systemsCancerHealth consequencesRelated conditionsEffective interventionsWomenConditions-IIISexSex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders
Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related disordersAlcohol useMajor depressive disorderAlcohol-related disordersAlcohol use disorderPosttraumatic stress disorderStress regulation systemComplex comorbiditiesDepressive disorderProblematic alcohol useUse disordersAlcohol misuseTherapeutic potentialTrauma exposureSubstance abuseStress disorderAnxiety disordersDisordersExposure resultsProgestogensNeurosteroidsNegative affectWomenComorbiditiesMale counterparts
2020
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years
Verplaetse TL, Cosgrove KP, Tanabe J, McKee SA. Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. Journal Of Neuroscience Research 2020, 99: 309-323. PMID: 32333417, PMCID: PMC7584757, DOI: 10.1002/jnr.24625.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol consumptionNarrative reviewBrain functionAlcohol useRisk of AUDMagnetic resonance imagingPositron emission tomographyDiffusion tensor imagingHigh-risk drinkingFunctional magnetic resonanceImaging outcomesSex/genderProblematic alcohol consumptionUse disordersResonance imagingEmission tomographySex/gender differencesRobust increaseTensor imagingBrain imaging researchRecent neuroimaging literatureWomenEvent-related potentialsNeurobiological underpinnings
2019
Sex differences in stress-related alcohol use
Peltier MR, Verplaetse TL, Mineur YS, Petrakis IL, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in stress-related alcohol use. Neurobiology Of Stress 2019, 10: 100149. PMID: 30949562, PMCID: PMC6430711, DOI: 10.1016/j.ynstr.2019.100149.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAlcohol use disorderAlcohol useSex differencesAlcohol-induced neurodegenerationStress reactivityPresent narrative reviewAlcohol-related health consequencesEarly life stressBrain stress systemsOvarian hormonesPsychiatric comorbidityStress-related drinkingProblematic alcohol useUse disordersNarrative reviewBrain regionsBehavioral treatmentHealth consequencesStress systemAvailable evidenceRole of stressAlcohol addictionWomenLife stressExamination of sex
2018
Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study
Verplaetse TL, Moore KE, Pittman BP, Roberts W, Oberleitner LM, Peltier M, Hacker R, Cosgrove KP, McKee SA. Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study. Nicotine & Tobacco Research 2018, 21: 1423-1428. PMID: 30239953, PMCID: PMC6751514, DOI: 10.1093/ntr/nty187.Peer-Reviewed Original ResearchConceptsE-cigarette useE-cigarette usersCigarette smoking statusE-cigarettesSmoking statusSmoking cessationCigarette smokersSmoking relapseGreater riskDaily e-cigarette usersWave 1Stratified analysisHigher oddsHealth StudyPotential riskSmokingRelapseDrug AdministrationElectronic cigarettesSmokersPopulation AssessmentPotential aidMenWomenRiskFemale Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease
Han MK, Arteaga-Solis E, Blenis J, Bourjeily G, Clegg DJ, DeMeo D, Duffy J, Gaston B, Heller NM, Hemnes A, Henske EP, Jain R, Lahm T, Lancaster LH, Lee J, Legato MJ, McKee S, Mehra R, Morris A, Prakash YS, Stampfli MR, Gopal-Srivastava R, Laposky AD, Punturieri A, Reineck L, Tigno X, Clayton J. Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 850-858. PMID: 29746147, PMCID: PMC6173069, DOI: 10.1164/rccm.201801-0168ws.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsthmaBehaviorComprehensionDisease ManagementEducationFemaleHumansLung DiseasesMiddle AgedNational Heart, Lung, and Blood Institute (U.S.)Pulmonary Disease, Chronic ObstructiveRisk AssessmentSeverity of Illness IndexSex FactorsSleep Apnea SyndromesSleep Wake DisordersUnited StatesWomen's HealthConceptsFemale sexFemale patientsLung diseaseSleep healthChronic obstructive pulmonary diseaseCase of lymphangioleiomyomatosisObstructive pulmonary diseaseSleep-disordered breathingBetter health outcomesNonneoplastic lung diseasesSex-based differencesCardiac morbidityPulmonary diseaseWomen's healthHealth outcomesLung developmentClinical implicationsPresentation differsDiseasePersonalized therapyGood healthWomenNIH OfficePatientsSleep biologySex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction
Verplaetse T, Morris ED, McKee SA, Cosgrove KP. Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction. Current Opinion In Behavioral Sciences 2018, 23: 196-202. PMID: 31341936, PMCID: PMC6656369, DOI: 10.1016/j.cobeha.2018.04.004.Peer-Reviewed Original ResearchSmoking addictionNicotinic acetylcholine receptor systemReceptor systemNon-nicotine factorsRecent imaging literatureSex differencesNicotine replacement therapyDopamine receptor systemAcetylcholine receptor systemNicotine-motivated behaviorsFuture medication developmentNicotine-related reinforcementTobacco smokingImaging findingsNicotine administrationReplacement therapyDopaminergic systemNeurochemical mechanismsNicotinic acetylcholineDopamine systemMedication developmentLines of evidenceSmokingImaging literatureWomen
2017
Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010–2011 Tobacco Use Supplement to the Current Population Survey
Smith PH, Zhang J, Weinberger AH, Mazure CM, McKee SA. Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010–2011 Tobacco Use Supplement to the Current Population Survey. Drug And Alcohol Dependence 2017, 178: 485-491. PMID: 28715776, PMCID: PMC6779031, DOI: 10.1016/j.drugalcdep.2017.05.046.Peer-Reviewed Original ResearchConceptsTransdermal nicotine patchUnassisted quit attemptsClinical trial dataTobacco Use SupplementQuit attemptsTrial dataClinical trial findingsReal-world effectivenessSample of smokersGender differencesRelevant gender differencesCessation optionsCessation medicationsCessation pharmacotherapyNicotine patchMedication interactionsSmoking cessationPotential confoundersTrial findingsVareniclineComparative effectivenessPropensity scoreCross-sectional dataWomenMedications
2016
Sex/gender differences in smoking cessation: A review
Smith PH, Bessette AJ, Weinberger AH, Sheffer CE, McKee SA. Sex/gender differences in smoking cessation: A review. Preventive Medicine 2016, 92: 135-140. PMID: 27471021, PMCID: PMC5085924, DOI: 10.1016/j.ypmed.2016.07.013.Peer-Reviewed Original ResearchConceptsProspective observational studyObservational studyCross-sectional investigationSex/gender differencesSmoking cessationEffectiveness trialCommunity-based interventionsLong-term abstinenceGender differencesSmoker prevalenceEfficacy trialsOutcome assessmentTreatment studiesEpidemiological investigationsMeet criteriaStudy sampleTrialsCessationWomenRelapseSmokingBio-psychoMenQualitative reviewReview
2015
Childhood Adversity Interacts With Adult Stressful Events to Predict Reduced Likelihood of Smoking Cessation Among Women but Not Men
Smith PH, Oberleitner LM, Smith KM, McKee SA. Childhood Adversity Interacts With Adult Stressful Events to Predict Reduced Likelihood of Smoking Cessation Among Women but Not Men. Clinical Psychological Science 2015, 4: 183-193. PMID: 27026829, PMCID: PMC4808300, DOI: 10.1177/2167702615584589.Peer-Reviewed Original ResearchSmoking cessationStressful life eventsChildhood adversityNon-daily smokersNational Epidemiologic SurveySex differencesLife eventsImportant sex differencesStress sensitization modelPsychiatric outcomesEpidemiologic SurveyClinical targetsRelated conditionsThree-way interactionCessationLower likelihoodEarly stressWomenStressful eventsWave 1MenCurrent studyFurther explorationAdversitySmokersImpact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men
Oberleitner LM, Smith PH, Weinberger AH, Mazure CM, McKee SA. Impact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men. Child Maltreatment 2015, 20: 301-308. PMID: 26130105, PMCID: PMC4868049, DOI: 10.1177/1077559515591270.Peer-Reviewed Original ResearchConceptsAlcohol useChildhood maltreatmentAlcohol dependenceFourth Edition alcohol dependencePoisson regression analysisNational Epidemiologic SurveyNegative alcohol-related outcomesProblematic alcohol useImpact of exposureEpidemiologic SurveyEarly interventionAlcohol-related outcomesMental disordersBehavioral treatmentRelated conditionsPrevention effortsStatistical ManualOutcome variablesAlcohol initiationWomenRegression analysisAgeMenFirst useMaltreatmentThe Relationship Between Childhood Physical and Emotional Abuse and Smoking Cessation Among U.S. Women and Men
Smith PH, Saddleson ML, Homish GG, McKee SA, Kozlowski LT, Giovino GA. The Relationship Between Childhood Physical and Emotional Abuse and Smoking Cessation Among U.S. Women and Men. Psychology Of Addictive Behaviors 2015, 29: 338-346. PMID: 25347015, PMCID: PMC4486346, DOI: 10.1037/adb0000033.Peer-Reviewed Original ResearchConceptsSerious psychological distressChildhood maltreatmentQuit attemptsActual quit attemptsCurrent cigarette smokersSuccessful quit attemptsU.S. adult smokersNational U.S. sampleLikelihood of smokingFemale smokersPsychological distressSmoking cessationCigarette smokersAdult smokersSmoking outcomesSmokingMore difficultyMaltreatmentSmokersU.S. sampleLower likelihoodTelephone surveyPath modelingMotivationWomenGender differences in age of smoking initiation and its association with health
Thompson AB, Tebes JK, McKee SA. Gender differences in age of smoking initiation and its association with health. Addiction Research & Theory 2015, 23: 413-420. PMID: 27499723, PMCID: PMC4972043, DOI: 10.3109/16066359.2015.1022159.Peer-Reviewed Original ResearchMajor depressive disorderNegative health outcomesHeart diseaseDepressive disorderHealth outcomesAnxiety disordersMore negative health outcomesHistory of smokingMental health statusNational Epidemiological SurveyPhysical health risksGender differencesAge of initiationSmoking startsAlcohol Related ConditionsEarly initiationLate initiatorsEpidemiological surveyLate initiationSmoking initiationHealth statusLogistic regressionRelated conditionsEarly initiatorsWomenGender Differences in Medication Use and Cigarette Smoking Cessation: Results From the International Tobacco Control Four Country Survey
Smith PH, Kasza KA, Hyland A, Fong GT, Borland R, Brady K, Carpenter MJ, Hartwell K, Cummings KM, McKee SA. Gender Differences in Medication Use and Cigarette Smoking Cessation: Results From the International Tobacco Control Four Country Survey. Nicotine & Tobacco Research 2015, 17: 463-472. PMID: 25762757, PMCID: PMC4402353, DOI: 10.1093/ntr/ntu212.Peer-Reviewed Original ResearchConceptsMedication useInternational Tobacco Control Four Country SurveySmoking cessationFour Country SurveyQuit attemptsCessation medication useCigarette smoking cessationGender differencesAdjusted modelingQuit attemptersNicotine patchSuccessful quittingSubsample of smokersAdult smokersLower oddsCountry SurveyWomenSelf-selected useCessationSmokersSCM useMenWaves 2006Survey wavesVareniclineTargeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence
Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence. Nicotine & Tobacco Research 2015, 17: 486-495. PMID: 25762760, PMCID: PMC4432402, DOI: 10.1093/ntr/ntu280.Peer-Reviewed Original ResearchConceptsSmoking cessationNoradrenergic systemClinical evidenceTobacco dependenceNoradrenergic activityMedication developmentPoor smoking cessation outcomesCause of morbiditySmoking cessation outcomesStress reactivitySex-specific mechanismsLower quit ratesNicotine-related reinforcementCurrent medicationsMedication effectivenessNicotine reinforcementCessation outcomesNoradrenergic agentsQuit ratesTreatment strategiesTobacco useNoradrenergic compoundsSmoking outcomesTreatment developmentWomen
2014
Consideration of Sex in Clinical Trials of Transdermal Nicotine Patch: A Systematic Review
Weinberger AH, Smith PH, Kaufman M, McKee SA. Consideration of Sex in Clinical Trials of Transdermal Nicotine Patch: A Systematic Review. Experimental And Clinical Psychopharmacology 2014, 22: 373-383. PMID: 25133506, PMCID: PMC4180800, DOI: 10.1037/a0037692.Peer-Reviewed Original ResearchConceptsTransdermal nicotine patchNicotine patchCessation outcomesClinical trialsSmoking cessationSmoking cessation treatmentMenstrual cycle phaseCessation treatmentSex-related variablesInclusion criteriaMEDLINE searchSmoking treatmentSide effectsBetter outcomesTreatment efficacyConsideration of sexSystematic reviewPotential articlesInclusion of sexSkin irritationMore womenTrialsOutcomesSexWomen