2022
JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton
Rafiq N, Lyons L, Gowrishankar S, De Camilli P, Ferguson S. JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton. Communications Biology 2022, 5: 5. PMID: 35013510, PMCID: PMC8748971, DOI: 10.1038/s42003-021-02945-x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAxonal TransportAxonsBiological TransportCytoskeletonHumansLysosomesNerve Tissue Proteins
2021
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons
Gowrishankar S, Lyons L, Rafiq NM, Roczniak-Ferguson A, De Camilli P, Ferguson SM. Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Molecular Biology Of The Cell 2021, 32: 1094-1103. PMID: 33788575, PMCID: PMC8351540, DOI: 10.1091/mbc.e20-06-0382.Peer-Reviewed Original ResearchConceptsAxonal transportAlzheimer's disease-related amyloid precursor proteinAmyloidogenic APP processingAmyloid precursor proteinDependence of neuronsHuman iPSCNeuronal cell biologyAPP processingAxonal lysosomesNeuronsLoss of JIP3Lysosome abundanceMovement of lysosomesPrecursor proteinCellular modelCritical regulatorStem cellsPluripotent stem cellsAβ42 peptideIPSCsLysosome transportLysosomesOverlapping rolePathology
2017
Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology
Gowrishankar S, Wu Y, Ferguson SM. Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology. Journal Of Cell Biology 2017, 216: 3291-3305. PMID: 28784610, PMCID: PMC5626538, DOI: 10.1083/jcb.201612148.Peer-Reviewed Original ResearchConceptsJNK-interacting protein 3Plaque pathologyAmyloid plaquesAxonal swellingsAmyloid precursor protein-processing enzymeAmyloidogenic amyloid precursor protein processingAmyloid precursor protein processingAlzheimer's disease (AD) amyloid plaquesAmyloid plaque pathologyPrecursor protein processingAβ peptide levelsFocal axonal swellingsDystrophic axonsAxonal lysosomesMouse modelPeptide levelsProtein 3Lysosome accumulationLysosome transportPrimary culturesImportant regulatorPlaquesPathologyVivo importanceDisease relevance