2017
Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology
Gowrishankar S, Wu Y, Ferguson SM. Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology. Journal Of Cell Biology 2017, 216: 3291-3305. PMID: 28784610, PMCID: PMC5626538, DOI: 10.1083/jcb.201612148.Peer-Reviewed Original ResearchConceptsJNK-interacting protein 3Plaque pathologyAmyloid plaquesAxonal swellingsAmyloid precursor protein-processing enzymeAmyloidogenic amyloid precursor protein processingAmyloid precursor protein processingAlzheimer's disease (AD) amyloid plaquesAmyloid plaque pathologyPrecursor protein processingAβ peptide levelsFocal axonal swellingsDystrophic axonsAxonal lysosomesMouse modelPeptide levelsProtein 3Lysosome accumulationLysosome transportPrimary culturesImportant regulatorPlaquesPathologyVivo importanceDisease relevance
2009
Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits
Ferguson S, Raimondi A, Paradise S, Shen H, Mesaki K, Ferguson A, Destaing O, Ko G, Takasaki J, Cremona O, Toole E, De Camilli P. Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits. Developmental Cell 2009, 17: 811-822. PMID: 20059951, PMCID: PMC2861561, DOI: 10.1016/j.devcel.2009.11.005.Peer-Reviewed Original ResearchConceptsEndocytic roleEndocytic clathrin-coated pitsBAR domain proteinsSense membrane curvatureClathrin-coated pitsWild-type cellsGTPase dynaminEndocytic intermediatesHigher eukaryotesDomain proteinsMembrane fissionActin dynamicsNumerous proteinsDynaminMembrane curvatureProtein upstreamTubular neckConcerted actionProteinActinCoordinated actionKey playersFunctional relationshipCellsSequence of events