2022
JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton
Rafiq N, Lyons L, Gowrishankar S, De Camilli P, Ferguson S. JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton. Communications Biology 2022, 5: 5. PMID: 35013510, PMCID: PMC8748971, DOI: 10.1038/s42003-021-02945-x.Peer-Reviewed Original Research
2017
Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology
Gowrishankar S, Wu Y, Ferguson SM. Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology. Journal Of Cell Biology 2017, 216: 3291-3305. PMID: 28784610, PMCID: PMC5626538, DOI: 10.1083/jcb.201612148.Peer-Reviewed Original ResearchConceptsJNK-interacting protein 3Plaque pathologyAmyloid plaquesAxonal swellingsAmyloid precursor protein-processing enzymeAmyloidogenic amyloid precursor protein processingAmyloid precursor protein processingAlzheimer's disease (AD) amyloid plaquesAmyloid plaque pathologyPrecursor protein processingAβ peptide levelsFocal axonal swellingsDystrophic axonsAxonal lysosomesMouse modelPeptide levelsProtein 3Lysosome accumulationLysosome transportPrimary culturesImportant regulatorPlaquesPathologyVivo importanceDisease relevance