2010
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010, 464: 852-857. PMID: 20305640, PMCID: PMC3422863, DOI: 10.1038/nature08851.Peer-Reviewed Original ResearchConceptsSpecific mesenchymal cellsMesenchymal cellsHuman bone marrow failureDeletion of Dicer1Osteolineage cellsTissue homeostasisHeterologous cellsDicer1 deletionGene expressionMature osteoblastsRegulatory nicheBone marrow failureDiamond syndromeMesenchymal subsetsStem cellsOsteoprogenitorsReduced expressionDeletionSecondary neoplastic diseaseStromal cellsMarrow failureDICER1CellsHaematopoiesisGenetic abnormalities
2009
Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.
Raaijmakers M, Mukherjee S, Guo S, Kobayashi T, Schoonmaker J, Aung Z, Ebert B, Al-Shahrour F, Hasserjian R, Vallet S, Scadden E, Lin C, Scadden D. Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells. Blood 2009, 114: 247. DOI: 10.1182/blood.v114.22.247.247.Peer-Reviewed Original ResearchDeletion of Dicer1Hematopoietic cellsMyelodysplastic syndromeHuman myelodysplastic syndromeOsteoprogenitor cellsHematopoietic abnormalitiesHematopoietic systemMesenchymal cellsWild-type environmentRegulation of hematopoiesisGene expression profilingWild-type hematopoietic cellsB cell progenitorsPrimitive hematopoietic cellsHematopoietic physiologyMiRNA biogenesisOrgan formationTranscriptional controlOsteolineage cellsNormal stem cellsGermline tissuesComparative genomic hybridizationMultiple lineagesExpression profilingBone marrow vascularity