2020
Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter
Eastman AE, Chen X, Hu X, Hartman AA, Morales A, Yang C, Lu J, Kueh HY, Guo S. Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter. Cell Reports 2020, 31: 107804. PMID: 32579930, PMCID: PMC7418154, DOI: 10.1016/j.celrep.2020.107804.Peer-Reviewed Original ResearchConceptsFluorescent reportersLive-cell fluorescent reporterCell cycle speedFluorescent timer proteinsCell proliferationCell cycle dynamicsRed fluorescent proteinFaster cycling cellsFate transitionsFusion reporterActive lociTimer proteinFluorescent proteinLength heterogeneityComplex tissuesHematopoietic cellsCycling cellsReporterFluorescence ratioCycle dynamicsProteinFunctional heterogeneityMouse strainsSolid tissuesCycle speed
2009
Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.
Raaijmakers M, Mukherjee S, Guo S, Kobayashi T, Schoonmaker J, Aung Z, Ebert B, Al-Shahrour F, Hasserjian R, Vallet S, Scadden E, Lin C, Scadden D. Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells. Blood 2009, 114: 247. DOI: 10.1182/blood.v114.22.247.247.Peer-Reviewed Original ResearchDeletion of Dicer1Hematopoietic cellsMyelodysplastic syndromeHuman myelodysplastic syndromeOsteoprogenitor cellsHematopoietic abnormalitiesHematopoietic systemMesenchymal cellsWild-type environmentRegulation of hematopoiesisGene expression profilingWild-type hematopoietic cellsB cell progenitorsPrimitive hematopoietic cellsHematopoietic physiologyMiRNA biogenesisOrgan formationTranscriptional controlOsteolineage cellsNormal stem cellsGermline tissuesComparative genomic hybridizationMultiple lineagesExpression profilingBone marrow vascularity