2007
Expression of Toll-like receptors in the human decidua.
Krikun G, Lockwood CJ, Abrahams VM, Mor G, Paidas M, Guller S. Expression of Toll-like receptors in the human decidua. Cellular And Molecular Biology 2007, 22: 847-54. PMID: 17503341, DOI: 10.14670/hh-22.847.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportCells, CulturedDeciduaEndometriumEndothelial CellsFemaleHumansImmunity, InnateImmunohistochemistryInterleukinsLipopolysaccharidesMyeloid Differentiation Factor 88NF-kappa BPeptidoglycanPoly I-CPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionToll-Like ReceptorsConceptsToll-like receptorsHuman deciduaFirst trimester elective terminationMaternal spiral arteriesInnate immune responseCesarean sectionSpiral arteriesThird trimesterCytokine productionElective terminationDecidual tissuesImmune responseLate gestationPregnant endometriumFetal membranesSurveillance moleculeHost defensePregnancyDeciduaMRNA levelsReceptorsMicrobial pathogensTrimesterEndometriumArtery
2006
Tumor Necrosis Factor-α and Interleukin-1β Regulate Interleukin-8 Expression in Third Trimester Decidual Cells Implications for the Genesis of Chorioamnionitis
Lockwood CJ, Arcuri F, Toti P, De Felice C, Krikun G, Guller S, Buchwalder LF, Schatz F. Tumor Necrosis Factor-α and Interleukin-1β Regulate Interleukin-8 Expression in Third Trimester Decidual Cells Implications for the Genesis of Chorioamnionitis. American Journal Of Pathology 2006, 169: 1294-1302. PMID: 17003486, PMCID: PMC1698845, DOI: 10.2353/ajpath.2006.060185.Peer-Reviewed Original ResearchConceptsTerm decidual cellsIL-8 expressionInterleukin-8 expressionTranscriptase-polymerase chain reactionDecidual cellsNeutrophil infiltrationIL-8TNF-alphaIL-8 secretion levelsIL-8 levelsIntense neutrophil infiltrationReverse transcriptase-polymerase chain reactionChain reactionInterleukin-1 betaTumor necrosis factorIL-8 mRNAEnzyme-linked immunosorbentIL-8 outputConcentration-response studiesNeutrophil infiltrateSteroidal milieuTerm deciduaTumor necrosisNecrosis factorImmunohistochemical staining
2005
Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts
Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts. Endocrinology 2005, 146: 4619-4626. PMID: 16055431, DOI: 10.1210/en.2005-0235.Peer-Reviewed Original ResearchConceptsGC receptorSmooth muscle cellsHuman placentaGR levelsHormone treatmentShort-term GC treatmentMuscle cellsLong-term hormone treatmentVascular smooth muscle cellsGR protein expressionGR mRNA levelsPlacental cell typesNormal term human placentasTotal GR levelsTerm human placentaCell typesGR antibodyGC treatmentHormone exposureStem villiCytotrophoblast cellsGlucocorticoid receptorPlacental fibroblastsTerminal villiVillous fibroblasts