2011
HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types
Schnell G, Joseph S, Spudich S, Price RW, Swanstrom R. HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types. PLOS Pathogens 2011, 7: e1002286. PMID: 22007152, PMCID: PMC3188520, DOI: 10.1371/journal.ppat.1002286.Peer-Reviewed Original ResearchConceptsHIV-1-associated dementiaCentral nervous systemHIV-1 populationsMacrophage-tropic virusesCerebrospinal fluidHuman immunodeficiency virus type 1 (HIV-1) infectionNervous systemCSF of subjectsT cell-tropic virusesViral replicationVirus type 1 infectionType 1 infectionHIV-1 replicationHIV-1 variantsHAD subjectsCNS infectionsTherapy initiationCCR5-tropicOvert dementiaVirological characteristicsNeurocognitive disordersHIV-1Virological stateSurface CD4CSF compartment
2009
Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection
Schnell G, Price RW, Swanstrom R, Spudich S. Compartmentalization and Clonal Amplification of HIV-1 Variants in the Cerebrospinal Fluid during Primary Infection. Journal Of Virology 2009, 84: 2395-2407. PMID: 20015984, PMCID: PMC2820937, DOI: 10.1128/jvi.01863-09.Peer-Reviewed Original ResearchConceptsHIV-1 populationsPrimary HIV-1 infectionCentral nervous systemHIV-1 infectionHIV-1 variantsDistinct HIV-1 populationsIndependent HIV-1 replicationHIV-1-infected individualsHuman immunodeficiency virus type 1Full-length env genesImmunodeficiency virus type 1HIV-1 transmissionSingle genome amplificationHIV-1 replicationHeteroduplex tracking assaysCourse of infectionSubset of subjectsVirus type 1Severe neurological diseaseClonal amplificationPeripheral bloodPrimary infectionCNS environmentCerebrospinal fluidNervous system
1999
Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease
Fatkin D, MacRae C, Sasaki T, Wolff M, Porcu M, Frenneaux M, Atherton J, Vidaillet H, Spudich S, De Girolami U, Seidman JG, Muntoni F, Müehle G, Johnson W, McDonough B, Seidman C. Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease. New England Journal Of Medicine 1999, 341: 1715-1724. PMID: 10580070, DOI: 10.1056/nejm199912023412302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid SequenceArrhythmias, CardiacCardiomyopathy, DilatedChromosome MappingChromosomes, Human, Pair 1FemaleGenes, DominantGenotypeHumansLamin Type ALaminsMaleMiddle AgedMolecular Sequence DataMuscular Dystrophy, Emery-DreifussMutation, MissenseNuclear ProteinsPedigreeProtein IsoformsSequence Analysis, DNAConceptsConduction system diseaseLamin A/C geneJoint contracturesCardiac conductionEmery-Dreifuss muscular dystrophySerum creatine kinase levelsProgressive conduction system diseaseMuscular dystrophyFamily membersChildhood-onset diseaseCreatine kinase levelsPercent of casesMissense mutationsHeart failureKinase levelsSudden deathNovel missense mutationSkeletal myopathyDiseaseGenetic causeC geneNuclear envelope protein lamin AIntermediate filament proteinsGene defectsGenetic defects