2023
Cerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection
Chan P, Moreland S, Sacdalan C, Kroon E, Colby D, Sriplienchan S, Pinyakorn S, Phanuphak N, Jagodzinski L, Valcour V, Vasan S, Paul R, Trautmann L, Spudich S, Team O. Cerebrospinal fluid pleocytosis is associated with HIV-1 neuroinvasion during acute infection. AIDS 2023, 38: 373-378. PMID: 37916464, PMCID: PMC10842649, DOI: 10.1097/qad.0000000000003777.Peer-Reviewed Original ResearchCSF HIV-1 RNAWhite blood cell countHIV-1 RNAAcute HIV infectionCp/mLCSF pleocytosisCSF samplesLower plasmaCerebrospinal fluid white blood cell countMedian CSF white blood cell countStage ICSF white blood cell countDetectable HIV-1 RNAFiebig stage IIIFiebig stages ICerebrospinal fluid pleocytosisT-cell countsAcute retroviral syndromeHigh viral loadBlood cell countCells/Blood CD4Acute infectionHIV infectionMedian age
2009
Compartmentalized Human Immunodeficiency Virus Type 1 Originates from Long-Lived Cells in Some Subjects with HIV-1–Associated Dementia
Schnell G, Spudich S, Harrington P, Price RW, Swanstrom R. Compartmentalized Human Immunodeficiency Virus Type 1 Originates from Long-Lived Cells in Some Subjects with HIV-1–Associated Dementia. PLOS Pathogens 2009, 5: e1000395. PMID: 19390619, PMCID: PMC2668697, DOI: 10.1371/journal.ppat.1000395.Peer-Reviewed Original ResearchConceptsHIV-1-associated dementiaCentral nervous systemAntiretroviral therapyCerebrospinal fluidNeurological diseasesAsymptomatic subjectsHIV-1-associated neurological diseasePeripheral CD4 cell countViral replicationHuman immunodeficiency virus type 1HIV-1 associated dementiaViral decayImmunodeficiency virus type 1HIV-1 genetic variantsCNS drug penetrationRapid viral decayViral decay kineticsCD4 cell countDrug-resistant virusesHigh viral loadHIV-1 variantsVirus type 1Productive viral replicationHAD subjectsCSF pleocytosis
2005
Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment
Spudich SS, Nilsson AC, Lollo ND, Liegler TJ, Petropoulos CJ, Deeks SG, Paxinos EE, Price RW. Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment. BMC Infectious Diseases 2005, 5: 98. PMID: 16266436, PMCID: PMC1299327, DOI: 10.1186/1471-2334-5-98.Peer-Reviewed Original ResearchConceptsAIDS dementia complexCSF HIV viral loadCSF viral loadAntiretroviral therapyHIV viral loadViral loadCD4 countCerebrospinal fluidCSF pleocytosisCSF infectionHIV infectionSystemic infectionHIV RNACSF WBCNeurological performanceCSF white blood cell countResultsIn cross-sectional analysisWhite blood cell countBlood CD4 countCNS HIV infectionCSF HIV RNAHigher CSF WBCLow CD4 countPersistent plasma viremiaHIV RNA levels