2014
TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219)
Nickerson K, Christensen S, Cullen J, Meng W, Luning Prak E, Shlomchik M. TLR9 restricts survival of anergic anti-DNA B cells in systemic lupus erythematosus yet is also required for their activation (BA4P.219). The Journal Of Immunology 2014, 192: 46.10-46.10. DOI: 10.4049/jimmunol.192.supp.46.10.Peer-Reviewed Original ResearchAnti-DNA B cellsSystemic lupus erythematosusB cellsB cell receptorAnti-DNA autoantibodiesLupus erythematosusBreaking B-cell toleranceAbsence of TLR9Reactive B cellsAutoimmunity in vivoB cell toleranceAutoimmune-prone MRLFunctional anergyAutoreactive cellsPeripheral repertoireAnergic cellsBone marrowExtrafollicular pathwayReceptor editingClinical hallmarkBCR signalingMouse modelBCR expressionTLR9Healthy individuals
2013
TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation
Nickerson KM, Christensen SR, Cullen JL, Meng W, Prak E, Shlomchik MJ. TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation. The Journal Of Immunology 2013, 190: 1447-1456. PMID: 23296704, PMCID: PMC3563726, DOI: 10.4049/jimmunol.1202115.Peer-Reviewed Original ResearchConceptsAnti-DNA B cellsB cellsBone marrowAbsence of TLR9Autoimmune prone animalsAutoimmune-prone MRLSystemic lupus erythematosusAnergic B cellsB cell compartmentB cell toleranceAb-forming cellsL chain editingB cell life spanFunctional anergyLupus erythematosusTLR9 expressionAutoreactive cellsPeripheral activationExtrafollicular pathwayPeripheral repertoireSystemic autoimmunityMouse modelAnergic cellsTLR9Cell life span
2008
Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α
Uccellini MB, Busconi L, Green NM, Busto P, Christensen SR, Shlomchik MJ, Marshak-Rothstein A, Viglianti GA. Autoreactive B Cells Discriminate CpG-Rich and CpG-Poor DNA and This Response Is Modulated by IFN-α. The Journal Of Immunology 2008, 181: 5875-5884. PMID: 18941176, PMCID: PMC2584609, DOI: 10.4049/jimmunol.181.9.5875.Peer-Reviewed Original ResearchConceptsAutoreactive B cellsDNA-reactive B cellsB cellsImmune complexesIFN-alphaLow-affinity autoreactive B cellsSystemic lupus erythematosusB cell proliferationBCR transgenic miceTLR9-dependent activationLupus erythematosusUnmethylated CpG dinucleotideTransgenic miceImmunostimulatory motifsCell proliferationActivation thresholdTLR9Normal repertoireCellsPotent ligandsBCRCpG island fragmentsDual engagementActivationImportant mechanism
2006
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Immunity 2006, 25: 417-428. PMID: 16973389, DOI: 10.1016/j.immuni.2006.07.013.Peer-Reviewed Original ResearchConceptsLupus-prone miceSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 7Toll-like receptor 9Absence of TLR9TLR7-deficient miceDevelopment of lupusPlasmacytoid DCsLupus erythematosusSerum IgGSusceptible miceAutoantibody specificitiesReceptor 7Receptor 9DNA autoantibodiesClinical diseaseIFN-alphaMurine modelLymphocyte activationTLR7TLR9Regulatory roleDiseaseMice
2005
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. Journal Of Experimental Medicine 2005, 202: 321-331. PMID: 16027240, PMCID: PMC2212997, DOI: 10.1084/jem.20050338.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibody FormationAutoantigensAutoimmunityB-LymphocytesDNADNA-Binding ProteinsHumansImmunity, InnateLupus NephritisMembrane GlycoproteinsMiceMice, KnockoutReceptors, Cell SurfaceRibonucleoproteins, Small NuclearSnRNP Core ProteinsToll-Like Receptor 3Toll-Like Receptor 9Toll-Like ReceptorsConceptsToll-like receptor 9TLR9-deficient miceAutoantibody productionAutoimmune diseasesReceptor 9Clinical autoimmune diseaseDNA-containing antigensSelf-nuclear antigensAnti-DNA autoantibody productionAnti-dsDNA autoantibodiesLupus-prone miceSystemic lupus erythematosusFormation of autoantibodiesSystemic autoimmune diseaseInnate immune activationAutoreactive B cellsLupus erythematosusAutoantibody formationMurine lupusImmune activationImmunologic toleranceAntichromatin autoantibodiesSmith antigenCpG DNAB cells