2024
Corrigendum: Translation regulation by a guanidine-II riboswitch is highly tunable in sensitivity, dynamic range, and apparent cooperativity
Focht C, Hiller D, Grunseich S, Strobel S. Corrigendum: Translation regulation by a guanidine-II riboswitch is highly tunable in sensitivity, dynamic range, and apparent cooperativity. RNA 2024, 30: 1259-2-1259-2. DOI: 10.1261/rna.080150.124.Peer-Reviewed Original ResearchFluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants
Tausta S, Fontaine K, Hillmer A, Strobel S. Fluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants. Plant Molecular Biology 2024, 114: 17. PMID: 38342783, PMCID: PMC10859346, DOI: 10.1007/s11103-023-01413-w.Peer-Reviewed Original ResearchConceptsFluoride exportMutant plantsWT plantsArabidopsis thaliana plantsSingle cell eukaryotesMulticellular plantsThaliana plantsCell eukaryotesFluoride toleranceTerminal tissuesMutantsFluoride transportPlantsFloral stemsWildtypeArabidopsisEukaryotesEnvironmental toxinsStemBacteriaPositron emission tomographyPrimary locusToxinThe Impact of Second-Shell Nucleotides on Ligand Specificity in Cyclic Dinucleotide Riboswitches
Barth K, Hiller D, Strobel S. The Impact of Second-Shell Nucleotides on Ligand Specificity in Cyclic Dinucleotide Riboswitches. Biochemistry 2024, 63: 487-497. PMID: 38329042, PMCID: PMC11306416, DOI: 10.1021/acs.biochem.3c00586.Peer-Reviewed Original ResearchCyclic di-GMPLigand specificityHigh-throughput mutational analysisLigand contactsRegulate downstream gene expressionDownstream gene expressionDistal nucleotidesTerminal helixSequence differencesChemically similar ligandsRiboswitchNucleotideLigand-binding pocketMutation analysisVariant familiesGene expressionSmall molecule ligandsBinding sitesBinding pocketStructural motifsCrystal structureMolecule ligandsLigandSequenceMotif
2023
Translation regulation by a guanidine-II riboswitch is highly tunable in sensitivity, dynamic range, and apparent cooperativity
Focht C, Hiller D, Grunseich S, Strobel S. Translation regulation by a guanidine-II riboswitch is highly tunable in sensitivity, dynamic range, and apparent cooperativity. RNA 2023, 29: 1126-1139. PMID: 37130702, PMCID: PMC10351892, DOI: 10.1261/rna.079560.122.Peer-Reviewed Original ResearchFluoride: Good in Toothpaste, Bad for Plants
Tausta S, Auslender A, Strobel S, Hiller D. Fluoride: Good in Toothpaste, Bad for Plants. Frontiers For Young Minds 2023, 11: 853533. DOI: 10.3389/frym.2023.853533.Peer-Reviewed Original Research
2017
PC69 UNUSUAL SPIROCYCLIC γ-LACTAMS, TRITICONES A AND B, NOVEL PHYTOTOXINS FROM THE PLANT PATHOGENIC FUNGI DRECHSLERA TRITICIREPENTIS AND D. CATENARIUM
Sugawara F, Samsoedin R, Takahashi N, Strobel G, Strobel S, Liu H, Clardy J. PC69 UNUSUAL SPIROCYCLIC γ-LACTAMS, TRITICONES A AND B, NOVEL PHYTOTOXINS FROM THE PLANT PATHOGENIC FUNGI DRECHSLERA TRITICIREPENTIS AND D. CATENARIUM. 2017, 525. DOI: 10.24496/intnaturalprod.1988.0_525.Peer-Reviewed Original Research
2016
Biatriospora (Ascomycota: Pleosporales) is an ecologically diverse genus including facultative marine fungi and endophytes with biotechnological potential
Kolařík M, Spakowicz D, Gazis R, Shaw J, Kubátová A, Nováková A, Chudíčková M, Forcina G, Kang K, Kelnarová I, Skaltsas D, Portero C, Strobel S, Narváez-Trujillo A. Biatriospora (Ascomycota: Pleosporales) is an ecologically diverse genus including facultative marine fungi and endophytes with biotechnological potential. Plant Systematics And Evolution 2016, 303: 35-50. DOI: 10.1007/s00606-016-1350-2.Peer-Reviewed Original ResearchTropical regionsBroad ecological rangeFacultative marine fungiProtein-coding genesRibosomal DNA sequencesTemperate forestsEcological rangeEcological dataEcological conceptsWoody plantsSpecies delimitationEstuarine environmentsHost associationsDiverse genusUnexplored diversityNew speciesBiotechnological potentialMarine fungiDNA sequencesInclusion of sequencesSpeciesEndophytesGenusPublic databasesPossible adaptation
2015
Stelliosphaerols A and B, sesquiterpene-polyol conjugates from an Ecuadorian fungal endophyte
Forcina G, Castro A, Bokesch H, Kucera K, McMahon J, Gustafson K, Strobel S. Stelliosphaerols A and B, sesquiterpene-polyol conjugates from an Ecuadorian fungal endophyte. Planta Medica 2015, 81 DOI: 10.1055/s-0035-1556389.Peer-Reviewed Original Research
2014
Corrigendum to “Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis” [Tetrahedron Lett. 54 (2013) 4058–4060]
Baraban E, Morin J, Phillips G, Phillips A, Strobel S, Handelsman J. Corrigendum to “Xyolide, a bioactive nonenolide from an Amazonian endophytic fungus, Xylaria feejeensis” [Tetrahedron Lett. 54 (2013) 4058–4060]. Tetrahedron Letters 2014, 55: 3126. DOI: 10.1016/j.tetlet.2014.04.012.Peer-Reviewed Original Research
2013
ChemInform Abstract: The Bacterial Second Messenger C‐di‐GMP: Probing Interactions with Protein and RNA Binding Partners Using Cyclic Dinucleotide Analogues.
Shanahan C, Strobel S. ChemInform Abstract: The Bacterial Second Messenger C‐di‐GMP: Probing Interactions with Protein and RNA Binding Partners Using Cyclic Dinucleotide Analogues. ChemInform 2013, 44: no-no. DOI: 10.1002/chin.201317261.Peer-Reviewed Original Research
2011
Changing the Culture of Science Education at Research Universities
Anderson W, Banerjee U, Drennan C, Elgin S, Epstein I, Handelsman J, Hatfull G, Losick R, O'Dowd D, Olivera B, Strobel S, Walker G, Warner I. Changing the Culture of Science Education at Research Universities. Science 2011, 331: 152-153. PMID: 21233371, DOI: 10.1126/science.1198280.Peer-Reviewed Original ResearchConceptsResearch universitiesLifelong learning skillsExpense of teachingScience educationLearning skillsTeaching loadDedicated teachersExtramural fundingNew knowledgeProfessorsUniversityEducationDependent worldEfforts of researchersDerogatory labelsTeachersTeachingStudentsSkillsReward systemDisciplinesInstitutionsResearch accomplishmentsResponsibilityFunding
2010
Endophyte Strain NRRL 50072 producing volatile organics is a species of Ascocoryne
Strobel G, Tomsheck A, Geary B, Spakowicz D, Strobel S, Mattner S, Mann R. Endophyte Strain NRRL 50072 producing volatile organics is a species of Ascocoryne. Mycology: An International Journal On Fungal Biology 2010, 1: 187-194. DOI: 10.1080/21501203.2010.510122.Peer-Reviewed Original Research
2009
Structural basis of ligand binding by a c-di-GMP riboswitch
Smith KD, Lipchock SV, Ames TD, Wang J, Breaker RR, Strobel SA. Structural basis of ligand binding by a c-di-GMP riboswitch. Nature Structural & Molecular Biology 2009, 16: 1218-1223. PMID: 19898477, PMCID: PMC2850612, DOI: 10.1038/nsmb.1702.Peer-Reviewed Original ResearchAurosphaeria, a novel coelomycetous genus
Lee S, Strobel G, Eisenman K, Geary B, Vargas P, Strobel S. Aurosphaeria, a novel coelomycetous genus. Mycotaxon 2009, 107: 463-472. DOI: 10.5248/107.463.Peer-Reviewed Original ResearchStructural and Chemical Basis for Glucosamine 6-Phosphate Binding and Activation of the glmS Ribozyme
Cochrane JC, Lipchock SV, Smith KD, Strobel SA. Structural and Chemical Basis for Glucosamine 6-Phosphate Binding and Activation of the glmS Ribozyme. Biochemistry 2009, 48: 3239-3246. PMID: 19228039, PMCID: PMC2854835, DOI: 10.1021/bi802069p.Peer-Reviewed Original Research
2008
89: Fungal endophytes as a platform for discovery of novel therapeutic strategies to inhibit pathogenic processes relevant for preterm birth
Lee S, Strobel S, Eisenman K, Dulay A, Boulanger L, Zhao G, Strobel G, Incarvito C, Buhimschi C, Buhimschi I. 89: Fungal endophytes as a platform for discovery of novel therapeutic strategies to inhibit pathogenic processes relevant for preterm birth. American Journal Of Obstetrics And Gynecology 2008, 199: s39. DOI: 10.1016/j.ajog.2008.09.116.Peer-Reviewed Original ResearchChemInform Abstract: Catalytic Strategies of Self‐Cleaving Ribozymes
Cochrane J, Strobel S. ChemInform Abstract: Catalytic Strategies of Self‐Cleaving Ribozymes. ChemInform 2008, 39: no-no. DOI: 10.1002/chin.200848274.Peer-Reviewed Original ResearchAn Uncharged Amine in the Transition State of the Ribosomal Peptidyl Transfer Reaction
Kingery DA, Pfund E, Voorhees RM, Okuda K, Wohlgemuth I, Kitchen DE, Rodnina MV, Strobel SA. An Uncharged Amine in the Transition State of the Ribosomal Peptidyl Transfer Reaction. Cell Chemical Biology 2008, 15: 493-500. PMID: 18482701, PMCID: PMC2851197, DOI: 10.1016/j.chembiol.2008.04.005.Peer-Reviewed Original ResearchConceptsTransition stateAminolysis reactionBond formationNitrogen-carbon bond formationLinear free energy relationshipSubstantial positive chargeChemical transition stateFree energy relationshipsPeptidyl transfer reactionTransfer reactionsActive sitePositive chargeUncharged amineReactionNucleophilesPuromycin derivativesDeprotonationChemistryDetailed understandingAminesFormationDerivativesChargeSolutionA relaxed active site after exon ligation by the group I intron
Lipchock SV, Strobel SA. A relaxed active site after exon ligation by the group I intron. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 5699-5704. PMID: 18408159, PMCID: PMC2311373, DOI: 10.1073/pnas.0712016105.Peer-Reviewed Original ResearchConceptsActive siteMetal ionsRelaxed active siteActive site metal ionScissile phosphateDirect metal coordinationHydrogen bonding contactsMetal coordinationBonding contactsTransition stateCrystal structureThermodynamic measurementsIonsGround stateStructureCoordinationStructural observationsTertiary interactionsIntron releaseExon ligationGroup I intronPhosphateComplexesReactionSecond step
2006
Structural Investigation of the GlmS Ribozyme Bound to Its Catalytic Cofactor
Cochrane JC, Lipchock SV, Strobel SA. Structural Investigation of the GlmS Ribozyme Bound to Its Catalytic Cofactor. Cell Chemical Biology 2006, 14: 97-105. PMID: 17196404, PMCID: PMC1847778, DOI: 10.1016/j.chembiol.2006.12.005.Peer-Reviewed Original Research